Music Video and Adolescent Resilience During Transplant

描述(申请人提供)：问题描述：干细胞移植(SCT)是许多需要高剂量放射或化疗的恶性肿瘤的首选治疗方法，是一种密集、多阶段的手术，具有许多风险，包括死亡，最近的研究表明，SCT对于青少年和年轻人(AYA)来说是一种特别有压力的手术，可能会导致短期和长期显著降低生活质量。广泛的目标：开发和测试治疗性音乐视频(TMV)干预的有效性，旨在提高接受SCT的AYA的弹性和生活质量。具体目标：确定与低剂量对照组相比，Aya是否被分配到TMV干预组，体验：1)减少与疾病相关的痛苦；2)改善家庭环境；3)增加感受到的社会支持；4)改善应对；5)更大的衍生意义；6)增加韧性和生活质量。次要目标包括定性地检查TMV干预和低剂量磁带书籍干预对Aya及其家庭照顾者的自我报告的益处。设计和方法：这项多点研究将采用随机对照试验方法。大约130名年龄在11到24岁之间的癌症接受SCT的Aya将被分配到TMV干预组或低剂量对照组。干预参与者将在董事会认证的音乐治疗师的指导下，根据他们在6个疗程中与癌症的经历制作音乐视频。低剂量对照参与者将参加6期磁带书籍计划。结果数据将在患者住院期间和移植后100天的多个时间点收集，使用自我报告清单评估特定目标中描述的结构。群体差异将使用线性混合模型方法进行检查，定性数据将使用Colaizzi现象学分析方法的改编进行分析。

DESCRIPTION (provided by applicant): Statement of Problem: Stem cell transplant (SCT), the curative therapy of choice for many malignancies that require high-dose radiation or chemotherapy, is an intensive, multi-phase procedure with many risks, including death, Recent studies suggest that SCT is a particularly stressful procedure for adolescents and young adults (AYA) and may result in significant short-and long-term decrements in quality of life. Broad Objective: To develop and test the efficacy of a therapeutic music video (TMV) intervention aimed at increasing resilience and quality of life of AYA undergoing SCT. Specific Aims: To determine whether AYA assigned to the TMV intervention, compared to a low dose control group, experience: 1) reduced illness-related distress; 2) improved family environment; 3) increased perceived social support; 4) improved coping; 5) greater derived meaning; 6) increased resilience and quality of life. Secondary aims include qualitatively examining the self-reported benefits of the TMV intervention and the low-dose books-on-tape intervention for AYA and their family caregivers. Design and Method: Randomized, controlled trial methods will be used for this multi-site study. Approximately 130 AYA between 11 and 24 years of age undergoing SCT for cancer will be assigned to either the TMV intervention group or to a low dose control group. Intervention participants will be guided by a board certified music therapist to develop a music video based on their experiences with cancer over the course of 6 sessions. Low dose control participants will take part in a 6 session books-on-tape program. Outcomes data will be collected at multiple time points during the patient's hospitalization and at 100 days post-transplant using self-report inventories assessing the constructs described in the Specific Aims. Group differences will be examined using a linear mixed models approach and qualitative data will be analyzed using an adaptation of Colaizzi's method of phenomenological analysis.