Music Video and Adolescent Resilience During Transplant

描述（由申请人提供）：问题说明：干细胞移植（SCT）是许多需要高剂量放疗或化疗的恶性肿瘤的治疗选择，是一个密集的、多阶段的手术，有许多风险，包括死亡。最近的研究表明，SCT对青少年和年轻人（AYA）来说是一个特别紧张的手术，可能导致显着的短期和长期的生活质量下降。目的：开发和测试治疗性音乐视频（TMV）干预的有效性，旨在提高AYA接受SCT的恢复力和生活质量。具体目的：确定与低剂量对照组相比，被分配到TMV干预组的AYA是否经历了：1)减少了疾病相关的痛苦；2)改善家庭环境；3)感知社会支持增加；4)改善应对；5)更大的派生意义；(6)提高了适应力和生活质量。次要目的包括定性检查对AYA及其家庭照顾者进行TMV干预和低剂量书面磁带干预的自我报告益处。设计与方法：本研究采用随机对照试验方法。大约130名年龄在11至24岁之间因癌症接受SCT的AYA将被分配到TMV干预组或低剂量对照组。干预参与者将在董事会认证的音乐治疗师的指导下，根据他们在6个疗程中的癌症经历制作一段音乐视频。低剂量控制组的参与者将参加一项为期6次的录音项目。结果数据将在患者住院期间的多个时间点和移植后100天收集，使用评估特定目标中描述的结构的自我报告清单。群体差异将使用线性混合模型方法进行检查，定性数据将使用Colaizzi的现象学分析方法进行分析。

DESCRIPTION (provided by applicant): Statement of Problem: Stem cell transplant (SCT), the curative therapy of choice for many malignancies that require high-dose radiation or chemotherapy, is an intensive, multi-phase procedure with many risks, including death, Recent studies suggest that SCT is a particularly stressful procedure for adolescents and young adults (AYA) and may result in significant short-and long-term decrements in quality of life. Broad Objective: To develop and test the efficacy of a therapeutic music video (TMV) intervention aimed at increasing resilience and quality of life of AYA undergoing SCT. Specific Aims: To determine whether AYA assigned to the TMV intervention, compared to a low dose control group, experience: 1) reduced illness-related distress; 2) improved family environment; 3) increased perceived social support; 4) improved coping; 5) greater derived meaning; 6) increased resilience and quality of life. Secondary aims include qualitatively examining the self-reported benefits of the TMV intervention and the low-dose books-on-tape intervention for AYA and their family caregivers. Design and Method: Randomized, controlled trial methods will be used for this multi-site study. Approximately 130 AYA between 11 and 24 years of age undergoing SCT for cancer will be assigned to either the TMV intervention group or to a low dose control group. Intervention participants will be guided by a board certified music therapist to develop a music video based on their experiences with cancer over the course of 6 sessions. Low dose control participants will take part in a 6 session books-on-tape program. Outcomes data will be collected at multiple time points during the patient's hospitalization and at 100 days post-transplant using self-report inventories assessing the constructs described in the Specific Aims. Group differences will be examined using a linear mixed models approach and qualitative data will be analyzed using an adaptation of Colaizzi's method of phenomenological analysis.