Music Video and Adolescent Resilience During Transplant

描述（申请人提供）：问题陈述：干细胞移植（SCT）是许多需要高剂量放疗或化疗的恶性肿瘤的治愈性治疗选择，是一种密集的多阶段手术，具有许多风险，包括死亡，最近的研究表明，SCT对青少年和年轻人（AYA）来说是一种特别紧张的手术，可能会导致显著的短期和长期的并发症。长期降低生活质量。广泛目标：开发和测试治疗性音乐视频（TMV）干预的有效性，旨在提高接受SCT的AYA的恢复力和生活质量。具体目标：为了确定与低剂量对照组相比，分配给TMV干预的AYA是否经历：1）减少疾病相关的痛苦; 2）改善家庭环境; 3）增加感知的社会支持; 4）改善应对; 5）更大的衍生意义; 6）增加弹性和生活质量。次要目的包括定性研究TMV干预和低剂量磁带书籍干预对AYA及其家庭照顾者的自我报告益处。设计和方法：本多中心研究将采用随机对照试验方法。大约130名年龄在11至24岁之间接受SCT治疗癌症的AYA将被分配到TMV干预组或低剂量对照组。干预参与者将由董事会认证的音乐治疗师指导，根据他们在6个疗程中的癌症经历制作音乐视频。低剂量对照组受试者将参加6次会议的磁带计划。将在患者住院期间和移植后100天的多个时间点收集结局数据，使用自我报告清单评估特定目标中描述的结构。将使用线性混合模型方法检查组差异，并使用Colaizzi现象学分析方法的改编对定性数据进行分析。

DESCRIPTION (provided by applicant): Statement of Problem: Stem cell transplant (SCT), the curative therapy of choice for many malignancies that require high-dose radiation or chemotherapy, is an intensive, multi-phase procedure with many risks, including death, Recent studies suggest that SCT is a particularly stressful procedure for adolescents and young adults (AYA) and may result in significant short-and long-term decrements in quality of life. Broad Objective: To develop and test the efficacy of a therapeutic music video (TMV) intervention aimed at increasing resilience and quality of life of AYA undergoing SCT. Specific Aims: To determine whether AYA assigned to the TMV intervention, compared to a low dose control group, experience: 1) reduced illness-related distress; 2) improved family environment; 3) increased perceived social support; 4) improved coping; 5) greater derived meaning; 6) increased resilience and quality of life. Secondary aims include qualitatively examining the self-reported benefits of the TMV intervention and the low-dose books-on-tape intervention for AYA and their family caregivers. Design and Method: Randomized, controlled trial methods will be used for this multi-site study. Approximately 130 AYA between 11 and 24 years of age undergoing SCT for cancer will be assigned to either the TMV intervention group or to a low dose control group. Intervention participants will be guided by a board certified music therapist to develop a music video based on their experiences with cancer over the course of 6 sessions. Low dose control participants will take part in a 6 session books-on-tape program. Outcomes data will be collected at multiple time points during the patient's hospitalization and at 100 days post-transplant using self-report inventories assessing the constructs described in the Specific Aims. Group differences will be examined using a linear mixed models approach and qualitative data will be analyzed using an adaptation of Colaizzi's method of phenomenological analysis.