Core 2: Biospecimen, Metabolomics, and Pathology Core

核心 2：生物样本、代谢组学和病理学核心

• 批准号: 10711640
• 负责人: Ian S. Hagemann
• 金额: $ 13.04万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-23 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711640
• 关键词: Award; Biostatistics Core; Blood; Cancer Center; Cancer Model; Cancer Patient; Catalogs; Cells; Characteristics; Clinical; Clinical Data; Collaborations; Collection; Communities; Consent; Correlative Study; Credentialing; Data; Databases; Development; Diagnosis; Disease; Eligibility Determination; Endometrial Carcinoma; Ensure; Equipment and supply inventories; Equity; Evaluation; Experimental Designs; Freezing; Future; Goals; Grant; Infrastructure; Institution; Institutional Review Boards; Isotopes; Leadership; Link; Liquid substance; Manuscripts; Metabolic; Methods; New Mexico; Newly Diagnosed; Nucleic Acids; Oklahoma; Organoids; Outcome; Pathology; Patients; Peer Review; Plasma; Preparation; Process; Prognostic Factor; Protocols documentation; Publications; Qualifying; Recurrence; Research; Research Design; Research Personnel; Research Project Grants; Resources; Route; Sampling; Serum; Services; Specimen; Standardization; Structure; Time; Tissues; Translational Research; Universities; Validation; Washington; Work; anticancer research; biobank; career; clinical database; data interoperability; data sharing; experience; genome sequencing; metabolomics; model development; operation; patient derived xenograft model; preservation; prevent; programs; prospective; sample collection; secondary analysis; success; tool; whole genome

PROJECT SUMMARY/ABSTRACT The goal of the Biospecimen, Metabolomics, and Pathology Core (BMP Core) is to create a federated, multi- institutional resource to provide high-quality, clinically annotated biospecimens, metabolomic analyses, and expert pathology review to all research projects in this SPORE application as well as future SPORE-sponsored DRP and CEP projects, while serving as an unparalleled biospecimen resource to the broader endometrial cancer research community. The Core will provide specific tissue and biosample-related services for each SPORE project. In addition, the BMP Core will prospectively build a biospecimen resource bank at WUSTL, OUHSC, and UNM by identifying cases of new and recurrent endometrial cancer at the participating institutions and facilitating the consent and procurement process. Tissue and fluid biospecimens from these patients will be collected, processed, and stored by leveraging the extensive infrastructure of existing biorepositories at the participating institutions. Clinical data will be collected prospectively by integrating with and extending existing clinical databases. Interactions with the Biostatistics Core will ensure interoperability of data tables maintained at each institution. The BMP Core will provide access to the world-class Center for Metabolomics and Isotope Tracing at WUSTL. Validated methods for sample processing and preservation, focused on optimizing metabolic analyses, will be provided to increase the scientific utility of all biospecimens collected. A transparent and equitable mechanism to publicize existing biospecimen resources and evaluate any request for their use will be implemented. As such, the BMP Core will supplement existing cancer center resources with focused expertise and effort to comprehensively collect, annotate, quality review, and distribute biospecimens specifically for translational endometrial cancer research.

项目摘要/摘要 生物测量，代谢组学和病理学核心（BMP核心）的目标是创建一个联合的，多的 提供高质量的，临床注释的生物测量，代谢组分分析和 专家病理学评论本孢子应用中的所有研究项目以及未来的孢子赞助 DRP和CEP项目，同时充当更广泛子宫内膜的无与伦比的生物测量资源 癌症研究界。核心将为每种提供特定的组织和生物样品相关服务 孢子项目。此外，BMP Core将前瞻性地在Wustl建立生物循环资源银行 OUHSC，以及通过在参与机构中识别新的和经常性子宫内膜癌病例 并促进同意和采购过程。这些患者的组织和液体生物测量将 通过利用现有生物库的广泛基础设施来收集，处理和存储 参与机构。临床数据将通过与现有的集成并扩展到前瞻性收集 临床数据库。与生物统计学核心的相互作用将确保维护数据表的互操作性 在每个机构。 BMP核心将提供进入世界一流代谢组学和同位素中心的访问权限 跟踪Wustl。经过验证的样品处理和保存方法，专注于优化 将提供代谢分析，以增加收集的所有生物测量的科学效用。一个 透明且公平的机制，以宣传现有的生物循环资源并评估任何请求 为了使用它们。因此，BMP核心将补充现有的癌症中心资源 凭借重点的专业知识和努力，以全面收集，注释，质量审查和分发 专门用于转化子宫内膜癌研究的生物测量。