Administrative and Biostatistics Core

行政和生物统计核心

• 批准号: 10629066
• 负责人: TONY R. HUNTER
• 金额: $ 22.79万
• 依托单位: SALK INSTITUTE FOR BIOLOGICAL STUDIES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-06 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629066
• 关键词: Adopted; Bioinformatics; Biometry; Biostatistics Core; Cancer Etiology; Cessation of life; Collaborations; Communication; Communities; Data; Data Analyses; Data Analytics; Data Set; Data Storage and Retrieval; Decision Making; Deposition; Disparate; Ensure; Epigenetic Process; Exhibits; Experimental Designs; Faculty; Foundations; Future; Goals; Heterogeneity; Information Technology; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of pancreas; Metabolic; Methods; Monitor; Pancreatic Ductal Adenocarcinoma; Patients; Reagent; Recommendation; Reporting; Reproducibility; Research; Research Project Grants; Resource Sharing; Resources; Risk; Services; Signal Pathway; System; Work; cost effective; data exchange; data integration; data sharing; experimental study; meetings; member; new therapeutic target; novel; organizational structure; programs; public repository; response; success; therapy resistant; tumor

PROJECT SUMMARY – Administrative and Biostatistics Core The overall goal of the Administrative and Biostatistics Core (Admin Core) is to facilitate research efforts toward understanding intrinsic resistance to therapy in pancreatic ductal adenocarcinoma (PDA). This will be accomplished by providing the three Research Projects (Projects) and the three Shared Resource Cores (Cores) with organizational support, professional project management, biostatistical expertise, data storage and sharing solutions, and a governance framework. The Admin Core will plan and coordinate meetings between the scientific teams, as well as between the scientific teams and the leadership groups. The Admin Core will include a Project Manager, who will provide professional project management services to ensure that stated objectives are successfully achieved. As part of this effort, the Project Manager will monitor Core activities to ensure that efforts of these cutting-edge scientific resources are integrated and coordinated, and that the Cores are operating effectively and efficiently to meet the needs of the Projects. The Project Manager will also establish a governance framework for resolving potential conflicts between team members and for managing resource utilization and budgetary concerns. The Admin Core will include a Biostatistics Unit that will be intimately involved in all experimental design and data analysis. The Biostatistics Unit will be responsible for ensuring that all experiments are sufficiently powered, and that the resulting data are analyzed using the most scientifically rigorous approaches. Novel methods will be developed when needed. One faculty-level statistician will split their effort between the Biostatics Unit and the bioinformatics team within the Tumor and Microenvironment Heterogeneity Core, coordinating communication and the transfer of data between these data analytic groups. Finally, the Admin Core will include a Data Curator who will help establish and oversee a centralized data-storage system into which all data generated by the scientific teams will be deposited and properly annotated. This resource will facilitate the integration of disparate datasets, as well as the exchange of data and reagents between the Projects, the Cores, and the external research community, as appropriate. Thus, the specific aims of the Admin Core are to: 1) provide overall organizational support including the coordination of meetings between the Projects, the Cores, and the leadership committees, 2) provide project management services to ensure that scientific objectives are achieved in an efficient and cost-effective manner, 3) provide biostatistical expertise to ensure experimental rigor and reproducibility, and 4) create and manage a centralized data storage and sharing system to enable data integration.

项目摘要-行政和生物统计核心 行政和生物统计核心（Admin Core）的总体目标是促进研究工作， 了解胰腺导管腺癌（PDA）的内在耐药性。这将是 通过提供三个研究项目（项目）和三个共享资源核心（核心）来完成 组织支持、专业项目管理、生物统计专业知识、数据存储和共享 解决方案和治理框架。管理核心将计划和协调 科学团队之间，以及科学团队和领导小组之间。管理核心将包括 项目经理，提供专业的项目管理服务，以确保既定目标 都成功实现了。作为这项工作的一部分，项目经理将监测核心活动，以确保 这些尖端科学资源的努力是综合和协调的，核心正在运作， 有效和高效地满足项目的需求。项目经理还将建立一个治理机制， 解决团队成员之间潜在冲突和管理资源利用的框架， 预算问题。行政核心将包括一个生物统计单位，将密切参与所有 实验设计和数据分析。生物统计股将负责确保所有实验 有足够的动力，并且使用最科学严谨的方法分析所得数据。 接近。必要时将开发新的方法。一个学院级的统计学家将分担他们的努力， 肿瘤和微环境中的生物统计学单位和生物信息学团队之间的合作 Heterocompatibility核心，协调这些数据分析组之间的通信和数据传输。 最后，管理核心将包括一个数据管理员，他将帮助建立和监督集中的数据存储 科学小组生成的所有数据都将存入该系统并作适当的注释。这 资源将促进不同数据集的整合，以及数据和试剂的交换 项目、核心和外部研究团体之间的沟通。因此，具体目标 行政核心的主要任务是：1）提供全面的组织支持，包括协调会议 在项目、核心和领导委员会之间，2）提供项目管理服务， 确保以有效和具有成本效益的方式实现科学目标，3）提供生物统计 专业知识，以确保实验的严格性和可重复性，以及4）创建和管理集中的数据存储 和共享系统，以实现数据集成。