Next generation training in HIV research: Immunity in the First 1000 days in mother-infant dyads (TIGRIS)

下一代艾滋病毒研究培训：母婴二人最初 1000 天的免疫力 (TIGRIS)

• 批准号: 10594540
• 负责人: Rana Chakraborty
• 金额: $ 3.02万
• 依托单位: STELLENBOSCH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594540
• 关键词: Accreditation; Africa; African; Basic Science; Cameroon; Child; Childhood; Clinic; Clinical; Clinical Sciences; Collaborations; Country; Development; Doctor of Philosophy; Educational Curriculum; Faculty; Funding; Gabon; Ghana; Goals; Growth; HIV; HIV Infections; Health; Immune; Immune System Diseases; Immunity; Immunology; Infant; International; Kenya; London; Malawi; Morehouse School of Medicine; Mothers; Neonatal; Phase; Pregnant Women; Reproductive Immunology; Research; Research Institute; Research Training; Series; South Africa; Specialist; Structure; Students; Teacher Professional Development; Training; Training Programs; Uganda; United States National Institutes of Health; Universities; adverse birth outcomes; college; innovation; laboratory experience; low and middle-income countries; medical schools; meetings; multidisciplinary; next generation; programs; reproductive; research study

This application describes the development of an innovative and unique HIV training program entitled: NexT generation traininG in HIV Research: Immunity in the First 1000 days in mother-infant dyadS” (TIGRIS). The program will leverage existing NIH funding to investigate specific hypotheses related to how HIV infection in the pregnant woman leads to adverse birth outcomes and ensuing pediatric immune dysfunction to develop rigorous clinical and basic science laboratory training for mentees. TIGRIS will be a multidisciplinary, international and pan-African HIV training program. The program will be implemented at Stellenbosch University in South Africa along with the Mayo Clinic, Rochester, USA. It will include Training Faculty in the US (Morehouse School of Medicine, Stanford University, Duke University, Weill Cornell Medical College, University of Cincinnati and Seattle Children’s Research Institute), the UK (Imperial College London and University of Oxford) to contribute to a number of research topics that will provide a basis for a more focused D43 HIV training program. The aim of TIGRIS will be to strengthen HIV research by studying reproductive and neonatal immunology in Africa and specifically around health in the mother-infant dyad during maternal HIV infection. This D71 application sets forth a series of immediate goals that will feed into longer terms goals in a subsequent D43 application: 1) Develop a curriculum and structured Post-Graduate Diploma in Reproductive and Neonatal Immunology that would be relevant for MMed (clinical), MSc, and PhD degrees. The program will incorporate preceptors from our assembled expert HIV specialist Faculty at SU and utilize existing HIIV- associated funded projects from our collaborators in the US and UK; 2) Develop a Reproductive Immunology Research Consortium in Africa (RIRCA). Leveraging on training programs, we will create a hub of excellence in reproductive and neonatal immunology research and training that caters for students from low-and-middle- income countries (LMICs) in Africa; 3) Expand and integrate collaborations with other LMIC countries in Africa, where we will initially focus on networking with Cameroon, Benin, Gabon, Ghana, Kenya, Malawi and Uganda. The specific objectives of the D71 planning phase will be to: 1) Hold two Faculty-wide network meetings to define a focused research training program; 2) Develop an accredited reproductive and neonatal immunology curriculum with a strong research training component in placental immunology and neonatal and infant immune ontogeny in the context of maternal HIV infection; 3) Develop a series of short- and long-term training programs; 4) Strengthen and expand inter-African and US partnerships and 5) Submit a D43 application.

该应用程序描述了创新且独特的艾滋病毒培训计划的发展： 艾滋病毒研究的下一代培训：母亲二元组的头1000天内的免疫力”（Tigris）。 该计划将利用现有的NIH资金来调查与艾滋病毒感染有关的特定假设 在孕妇导致不良的出生结果并确保儿科免疫功能障碍发展 严格的临床和基础科学实验室培训。 Tigris将是一个多学科的人， 国际和泛非艾滋病毒培训计划。该程序将在Stellenbosch实施 南非的大学以及美国罗切斯特的梅奥诊所。它将包括培训教师 美国（莫尔豪斯医学院，斯坦福大学，杜克大学，威尔·康奈尔医学院， 辛辛那提大学和西雅图儿童研究所，英国（伦敦帝国学院和 牛津大学）为许多研究主题做出了贡献，这些研究将为更加集中提供基础 D43 HIV培训计划。底格里斯的目的是通过研究生殖和 非洲的新生儿免疫学，尤其是在母亲艾滋病毒期间母亲二元的健康状况 感染。该D71应用程序阐明了一系列的直接目标，这些目标将在 随后的D43应用程序：1）开发了生殖的课程和结构化研究生文凭 新生儿免疫学与MMED（临床），MSC和PHD学位有关。该程序将 合并来自SU的组装专家HIV专家学院的受体，并利用现有的HIIV- 我们在美国和英国的合作者的相关资助项目； 2）发展生殖免疫学 非洲研究财团（RIRCA）。利用培训计划，我们将创建一个卓越的枢纽 生殖和新生儿免疫学研究和培训，可满足来自中低和中间的学生 非洲收入国家（LMIC）； 3）与非洲其他LMIC国家扩展和整合合作， 我们最初将专注于与喀麦隆，贝宁，加蓬，加纳，肯尼亚，马拉维和 乌干达。 D71计划阶段的特定对象将是：1）持有两个教师的网络 会议定义重点研究培训计划； 2）开发认可的生殖和新生儿 免疫学课程具有强大的研究培训组成部分，并在新生儿和新生儿中 在母体HIV感染的背景下，婴儿免疫个体发育； 3）发展一系列短期和长期 培训计划； 4）加强和扩大非洲间和美国合作伙伴关系，5）提交D43申请。