Next generation training in HIV research: Immunity in the First 1000 days in mother-infant dyads (TIGRIS)

本申请描述了一个创新的和独特的艾滋病毒培训计划的发展，题为： 艾滋病毒研究中的NextT世代培训：母婴双胞胎头1000天的免疫力”（TIGRIS）。 该计划将利用现有的NIH资金来调查与HIV感染如何相关的特定假设。 导致不良的出生结果和随后的儿科免疫功能障碍， 为学员提供严格的临床和基础科学实验室培训。TIGRIS将是一个多学科， 国际和泛非艾滋病毒培训方案。该计划将在斯泰伦博斯实施 沿着南非大学与美国罗切斯特的马约诊所。它将包括培训学院， 美国（莫尔豪斯医学院，斯坦福大学，杜克大学，威尔康奈尔医学院， 美国辛辛那提大学和西雅图儿童研究所）、英国（帝国理工学院伦敦和 牛津大学），以促进一些研究课题，这将提供一个基础， D43艾滋病毒培训方案。TIGRIS的目的是通过研究生殖和生殖健康， 新生儿免疫学在非洲，特别是围绕健康的母婴二人组在孕产妇艾滋病毒 感染这个D 71应用程序提出了一系列短期目标，这些目标将在一个 随后的D43申请：1）制定课程和结构化的研究生文凭在生殖和 新生儿免疫学，这将是相关的MMed（临床），硕士和博士学位。该计划将 从我们的集合专家艾滋病毒专家在SU学院结合导师，并利用现有的HIV- 我们在美国和英国的合作者资助的相关项目; 2）开发生殖免疫学 非洲研究联合会（RIRCA）。利用培训计划，我们将在以下方面建立一个卓越的中心 生殖和新生儿免疫学研究和培训，以满足学生从低和中等， 3）扩大并整合与非洲其他低收入国家的合作， 在那里，我们最初将重点与喀麦隆、贝宁、加蓬、加纳、肯尼亚、马拉维和 乌干达D 71规划阶段的具体目标是：1）保持两个全学院网络 会议，以确定一个重点研究培训计划; 2）制定一个认可的生殖和新生儿 免疫学课程，在胎盘免疫学和新生儿免疫学方面具有很强的研究培训成分， 在母亲感染艾滋病毒的情况下，婴儿的免疫个体发育; 3）制定一系列短期和长期的 培训计划; 4）加强和扩大非洲和美国的伙伴关系和5）提交D43申请。

This application describes the development of an innovative and unique HIV training program entitled: NexT generation traininG in HIV Research: Immunity in the First 1000 days in mother-infant dyadS” (TIGRIS). The program will leverage existing NIH funding to investigate specific hypotheses related to how HIV infection in the pregnant woman leads to adverse birth outcomes and ensuing pediatric immune dysfunction to develop rigorous clinical and basic science laboratory training for mentees. TIGRIS will be a multidisciplinary, international and pan-African HIV training program. The program will be implemented at Stellenbosch University in South Africa along with the Mayo Clinic, Rochester, USA. It will include Training Faculty in the US (Morehouse School of Medicine, Stanford University, Duke University, Weill Cornell Medical College, University of Cincinnati and Seattle Children’s Research Institute), the UK (Imperial College London and University of Oxford) to contribute to a number of research topics that will provide a basis for a more focused D43 HIV training program. The aim of TIGRIS will be to strengthen HIV research by studying reproductive and neonatal immunology in Africa and specifically around health in the mother-infant dyad during maternal HIV infection. This D71 application sets forth a series of immediate goals that will feed into longer terms goals in a subsequent D43 application: 1) Develop a curriculum and structured Post-Graduate Diploma in Reproductive and Neonatal Immunology that would be relevant for MMed (clinical), MSc, and PhD degrees. The program will incorporate preceptors from our assembled expert HIV specialist Faculty at SU and utilize existing HIIV- associated funded projects from our collaborators in the US and UK; 2) Develop a Reproductive Immunology Research Consortium in Africa (RIRCA). Leveraging on training programs, we will create a hub of excellence in reproductive and neonatal immunology research and training that caters for students from low-and-middle- income countries (LMICs) in Africa; 3) Expand and integrate collaborations with other LMIC countries in Africa, where we will initially focus on networking with Cameroon, Benin, Gabon, Ghana, Kenya, Malawi and Uganda. The specific objectives of the D71 planning phase will be to: 1) Hold two Faculty-wide network meetings to define a focused research training program; 2) Develop an accredited reproductive and neonatal immunology curriculum with a strong research training component in placental immunology and neonatal and infant immune ontogeny in the context of maternal HIV infection; 3) Develop a series of short- and long-term training programs; 4) Strengthen and expand inter-African and US partnerships and 5) Submit a D43 application.