Next generation training in HIV research: Immunity in the First 1000 days in mother-infant dyads (TIGRIS)

本申请描述了一项创新和独特的艾滋病毒培训计划的发展，题为： 艾滋病毒研究的下一代培训：母婴二体最初1000天的免疫力“(底格里斯)。 该计划将利用NIH现有的资金来调查与艾滋病毒感染如何相关的具体假设 在孕妇中会导致不良的分娩结局和随之而来的儿科免疫功能障碍的发展 为学员提供严格的临床和基础科学实验室培训。底格里斯将是一个多学科的， 国际和泛非艾滋病毒培训方案。该计划将在斯泰伦博施实施 南非大学和美国罗切斯特的梅奥诊所。它将包括培训学院在 美国(莫尔豪斯医学院，斯坦福大学，杜克大学，威尔·康奈尔医学院， 辛辛那提大学和西雅图儿童研究所)、英国(伦敦帝国理工学院和 牛津大学)为一些研究课题做出贡献，这些课题将为更有针对性的 D43艾滋病毒培训计划。底格里斯的目标将是通过研究生殖和生殖系统来加强艾滋病毒研究。 非洲的新生儿免疫学，特别是关于母亲艾滋病毒期间母婴二元组的健康 感染。这份D71申请列出了一系列近期目标，这些目标将在 随后的D43申请：1)制定生殖和生殖专业的课程和结构化研究生文凭 与医学硕士(临床)、硕士和博士学位相关的新生儿免疫学。该计划将 整合苏州大学艾滋病专家学院的教官，并利用现有的HIIV- 我们在美国和英国的合作者资助的相关项目；2)开发生殖免疫学 非洲研究联盟(RIRCA)。利用培训计划，我们将创建一个卓越的中心 面向中低年级学生的生殖和新生儿免疫学研究与培训 非洲收入国家；3)扩大和整合与非洲其他收入国家的合作， 我们最初将重点放在与喀麦隆、贝宁、加蓬、加纳、肯尼亚、马拉维和 乌干达。D71规划阶段的具体目标是：1)建立两个全系网络 会议以确定有重点的研究培训计划；2)制定经认可的生殖和新生儿 免疫学课程，包含强大的胎盘免疫学和新生儿免疫学研究培训部分 母体HIV感染背景下的婴儿免疫个体发育；3)发展一系列短期和长期的 培训计划；4)加强和扩大非洲和美国之间的伙伴关系；5)提交D43申请。

This application describes the development of an innovative and unique HIV training program entitled: NexT generation traininG in HIV Research: Immunity in the First 1000 days in mother-infant dyadS” (TIGRIS). The program will leverage existing NIH funding to investigate specific hypotheses related to how HIV infection in the pregnant woman leads to adverse birth outcomes and ensuing pediatric immune dysfunction to develop rigorous clinical and basic science laboratory training for mentees. TIGRIS will be a multidisciplinary, international and pan-African HIV training program. The program will be implemented at Stellenbosch University in South Africa along with the Mayo Clinic, Rochester, USA. It will include Training Faculty in the US (Morehouse School of Medicine, Stanford University, Duke University, Weill Cornell Medical College, University of Cincinnati and Seattle Children’s Research Institute), the UK (Imperial College London and University of Oxford) to contribute to a number of research topics that will provide a basis for a more focused D43 HIV training program. The aim of TIGRIS will be to strengthen HIV research by studying reproductive and neonatal immunology in Africa and specifically around health in the mother-infant dyad during maternal HIV infection. This D71 application sets forth a series of immediate goals that will feed into longer terms goals in a subsequent D43 application: 1) Develop a curriculum and structured Post-Graduate Diploma in Reproductive and Neonatal Immunology that would be relevant for MMed (clinical), MSc, and PhD degrees. The program will incorporate preceptors from our assembled expert HIV specialist Faculty at SU and utilize existing HIIV- associated funded projects from our collaborators in the US and UK; 2) Develop a Reproductive Immunology Research Consortium in Africa (RIRCA). Leveraging on training programs, we will create a hub of excellence in reproductive and neonatal immunology research and training that caters for students from low-and-middle- income countries (LMICs) in Africa; 3) Expand and integrate collaborations with other LMIC countries in Africa, where we will initially focus on networking with Cameroon, Benin, Gabon, Ghana, Kenya, Malawi and Uganda. The specific objectives of the D71 planning phase will be to: 1) Hold two Faculty-wide network meetings to define a focused research training program; 2) Develop an accredited reproductive and neonatal immunology curriculum with a strong research training component in placental immunology and neonatal and infant immune ontogeny in the context of maternal HIV infection; 3) Develop a series of short- and long-term training programs; 4) Strengthen and expand inter-African and US partnerships and 5) Submit a D43 application.