Partnership for Research in Emerginig Viral Infections-Sierra Leone (PREVSL)

项目摘要/摘要：最近的埃博拉疫情暴露了塞拉利昂S卫生系统的脆弱性 并强调了到目前为止支持一个运行良好的系统所需的投资不足 能够应对如此大规模的疾病爆发。改善优质医疗服务的提供 对于地方性病毒性出血热(VHF)患者，如拉沙热(LF)，同时加强 在未来埃博拉、塞拉利昂等VHF疫情暴发期间进行临床试验的能力必须增强 它拥有合格的卫生专业人员，他们在实施科学和 进行临床试验。 我们刚刚完成了为西非新兴流行病病毒研究培训提供的规划补助金 埃博拉广泛传播的国家-几内亚、利比里亚和塞拉利昂(D71TW010411)， 使我们能够评估我们国内合作伙伴组织的现有研究能力，同时完善我们的 寻求最佳办法的战略，以弥补这一能力方面的差距。这与我们广博的知识相结合 和在塞拉利昂进行甚高频研究的历史；以及近20年的机构管理经验 研究、培训和能力建设赠款；我们在此提出我们的综合研究培训计划 响应PAR-18-840-全球传染病研究培训。 我们寻求大幅提升塞拉利昂校长S的实施科学研究能力 医学院、塞拉利昂大学(USL)、医学院和附属健康科学学院 (COMAHS)；以及凯内马政府医院(KGH)通过 拟议的新出现病毒感染研究伙伴关系--塞拉利昂[宣布 “沪指西尔”]。 我们的具体目标是1)提高KGH和COMAHS的研究能力，以便进行科学研究 有效和伦理上可接受的临床试验，重点是埃博拉、拉萨和其他甚高频；2)加强和 扩大KGH和COMAHS研究库，专注于临床实施科学研究 VHF患者的管理；以及3)培养PREVSL学员/校友的创新指导研究 目的：探讨VHF的临床处理。我们的综合培训计划将包括 (1)长期的临床研究硕士培训，重点是疫苗临床试验能力；(2)短期- 至中期临床试验管理培训，以加强南南合作并建立区域 网络；(3)保健服务实施科学研究方面的短期和长期能力建设 公共卫生方面的国内短期课程和硕士培训；(4)KGH的可持续能力建设 和COMAHS，用于管理和管理未来的研究资助机会。

Project Summary/ Abstract: The recent Ebola epidemic exposed the fragility of Sierra Leone´s health system and highlighted the inadequate investments to date that are needed to support a well-functioning system capable of responding to a disease outbreak of this magnitude. To improve delivery of quality health services for patients with endemic viral hemorrhagic fevers (VHF) such as Lassa fever (LF), while strengthening capacity to conduct clinical trials during future epidemic VHF outbreaks such as Ebola, Sierra Leone must grow its pool of qualified health professionals with the methodological skills in implementation science and the conduct of clinical trials. We have just completed a Planning Grant for Emerging Epidemic Virus Research Training for West African Countries with Widespread Transmission of Ebola- Guinea, Liberia, and Sierra Leone (D71TW010411), that has allowed us to evaluate existing research capacity of our in-country partner organizations, while refining our strategies for best approaches to address gaps in that capacity. Combining this with our extensive knowledge and history of conducting VHF research in Sierra Leone; as well as nearly two-decades managing institutional research, training, and capacity-building grants; we propose here our comprehensive research training plan in response to PAR-18-840-Global Infectious Disease Research Training. We seek to substantially advance implementation science research capacity at Sierra Leone´s principal medical school, the University of Sierra Leone (USL), College of Medicine and Allied Health Sciences (COMAHS); as well as clinical trial infrastructure at the Kenema Government Hospital (KGH) through the proposed Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) [pronounced “Prev Sil”]. Our Specific Aims are to 1) Enhance research capacity at KGH and COMAHS for the conduct of scientifically valid and ethically acceptable clinical trials, with a focus on Ebola, Lassa, and other VHF; 2) Strengthen and expand the KGH and COMAHS research pool with a focus on Implementation Science research for the clinical management of patients with VHF; and 3) Nurture innovative mentored research by PREVSL trainees/alumni to address the clinical management of VHF. Our comprehensive training program will consist of a combination of (1) long-term Masters training in clinical investigation with a focus on vaccine clinical trial capacity; (2) short- to medium-term clinical trial management training that reinforces south-south collaborations and builds regional networks; (3) short and long-term capacity building in health services implementation science research through in-country short courses and Masters training in Public Health; and (4) sustainable capacity building at KGH and COMAHS for the management and administration of future research grant opportunities.