Partnership for Research in Emerginig Viral Infections-Sierra Leone (PREVSL)

塞拉利昂新兴病毒感染研究伙伴关系 (PREVSL)

• 批准号: 10754357
• 负责人: D. Troy Moon
• 金额: $ 4.44万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10754357
• 关键词: Partnership; Research; Emerginig; Viral; Infections

Project Summary/ Abstract: The recent Ebola epidemic exposed the fragility of Sierra Leone´s health system and highlighted the inadequate investments to date that are needed to support a well-functioning system capable of responding to a disease outbreak of this magnitude. To improve delivery of quality health services for patients with endemic viral hemorrhagic fevers (VHF) such as Lassa fever (LF), while strengthening capacity to conduct clinical trials during future epidemic VHF outbreaks such as Ebola, Sierra Leone must grow its pool of qualified health professionals with the methodological skills in implementation science and the conduct of clinical trials. We have just completed a Planning Grant for Emerging Epidemic Virus Research Training for West African Countries with Widespread Transmission of Ebola- Guinea, Liberia, and Sierra Leone (D71TW010411), that has allowed us to evaluate existing research capacity of our in-country partner organizations, while refining our strategies for best approaches to address gaps in that capacity. Combining this with our extensive knowledge and history of conducting VHF research in Sierra Leone; as well as nearly two-decades managing institutional research, training, and capacity-building grants; we propose here our comprehensive research training plan in response to PAR-18-840-Global Infectious Disease Research Training. We seek to substantially advance implementation science research capacity at Sierra Leone´s principal medical school, the University of Sierra Leone (USL), College of Medicine and Allied Health Sciences (COMAHS); as well as clinical trial infrastructure at the Kenema Government Hospital (KGH) through the proposed Partnership for Research in Emerging Viral Infections-Sierra Leone (PREVSL) [pronounced “Prev Sil”]. Our Specific Aims are to 1) Enhance research capacity at KGH and COMAHS for the conduct of scientifically valid and ethically acceptable clinical trials, with a focus on Ebola, Lassa, and other VHF; 2) Strengthen and expand the KGH and COMAHS research pool with a focus on Implementation Science research for the clinical management of patients with VHF; and 3) Nurture innovative mentored research by PREVSL trainees/alumni to address the clinical management of VHF. Our comprehensive training program will consist of a combination of (1) long-term Masters training in clinical investigation with a focus on vaccine clinical trial capacity; (2) short- to medium-term clinical trial management training that reinforces south-south collaborations and builds regional networks; (3) short and long-term capacity building in health services implementation science research through in-country short courses and Masters training in Public Health; and (4) sustainable capacity building at KGH and COMAHS for the management and administration of future research grant opportunities.

项目概要/摘要：最近的埃博拉疫情暴露了塞拉利昂卫生系统的脆弱性 并强调了迄今为止支持一个运作良好的系统所需的投资不足 有能力应对这种规模的疾病爆发。改善优质保健服务的提供 对于拉沙热（LF）等地方性病毒性出血热（VHF）患者，同时加强 在未来埃博拉等流行性VHF疫情期间进行临床试验的能力，塞拉利昂必须增长 拥有实施科学方法技能的合格卫生专业人员人才库， 进行临床试验。 我们刚刚完成了西非新兴流行病病毒研究培训的规划赠款 埃博拉病毒广泛传播的国家-几内亚、利比里亚和塞拉利昂（D 71 TW 010411）， 使我们能够评估我们的国内合作伙伴组织的现有研究能力，同时完善我们的 解决这一能力差距的最佳办法战略。结合我们广泛的知识 在塞拉利昂进行甚高频研究的历史;以及近二十年的管理机构 研究、培训和能力建设赠款;我们在此提出我们的综合研究培训计划 PAR-18-840-全球传染病研究培训。 我们寻求大幅提高塞拉利昂主要国家的实施科学研究能力。 医学院，塞拉利昂大学（USL），医学和联合健康科学学院 （COMAHS）;以及凯内马政府医院（KGH）的临床试验基础设施， 拟议的塞拉利昂新病毒预防研究伙伴关系（PREVSL） “Prev Sil”]。 我们的具体目标是：1）提高KGH和COMAHS的研究能力，以科学地进行 有效和道德上可接受的临床试验，重点是埃博拉病毒，拉沙，和其他甚高频; 2）加强和 扩大KGH和COMAHS研究池，重点是临床应用科学研究 VHF患者的管理;以及3）培养PREVSL学员/校友的创新指导研究 以解决VHF的临床管理问题。我们的综合培训计划将包括 （1）长期的临床研究硕士培训，重点是疫苗临床试验能力;（2）短期- 中期临床试验管理培训，加强南南合作， （3）通过以下途径，在卫生服务实施科学研究方面进行短期和长期能力建设： 国内短期课程和公共卫生硕士培训;（4）KGH的可持续能力建设 和COMAHS的管理和未来的研究补助金的机会。