Core 3: Pathology & Biospecimens Core
核心 3:病理学
基本信息
- 批准号:10716159
- 负责人:
- 金额:$ 15.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-19 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAsian AmericansAsian populationBiological Specimen BanksBloodBlood specimenBreastCancer BurdenCancer CenterCancer PatientCancer Research ProjectCellsCholine KinaseClinicalCohort StudiesCollectionColorectalColorectal CancerCommunitiesCommunity HospitalsCommunity ParticipationConsentCultural SensitivityDevelopmentDiagnosisDisparateEndometrial CarcinomaEndometriumEnsureEquityEthnic PopulationEtiologyExcess MortalityFecesFilipinoFormalinFoundationsFreezingFutureGoalsHawaiiHexokinase 2HumanImageIndividualInfrastructureInvestigationJapaneseJapanese AmericanLengthLiverLungMDM2 geneMalignant NeoplasmsMalignant neoplasm of liverMalignant neoplasm of lungMalignant neoplasm of pancreasMammary Gland ParenchymaMedicalMethylationMinority GroupsMinority Health ResearchMultiple MyelomaNative HawaiianNative Hawaiian or Other Pacific IslanderNot Hispanic or LatinoOralOral cavityOrganoidsOropharyngealOutcomePacific IslanderParaffin EmbeddingPathogenesisPathologyPathway interactionsPopulationPrimary carcinoma of the liver cellsProceduresProgram Research Project GrantsProtein KinaseReliability of ResultsReportingResearchResearch PersonnelResourcesSPHK1 enzymeSamoanSamplingSlideSomatomedinsSpecimenStandardizationStomachTP53 geneTestingTissuesTranslational ResearchTumor TissueUniversitiesUrineViral hepatitisanticancer researchbiobankcancer health disparitycancer riskcareerdiagnosis standardepidemiology studyethnic differenceethnic disparityethnic diversityethnic minorityethnic minority populationexperiencehuman subjectmalignant breast neoplasmmalignant stomach neoplasmmelanomaminimally invasiveminority communitiesminority health disparitymortalitymulti-ethnicnonalcoholic steatohepatitisprogramsprospectiveracial differenceracial disparityracial minorityracial minority populationrepositorysample collectiontelomeretranslational cancer researchtranslational potentialtumortumor registry
项目摘要
SUMMARY /ABSTRACT
Access to relevant biospecimens is critical to translational research on minority populations. The lack of
research specimens from racial and ethnic minority populations in the U.S. remains a barrier to understanding
racial/ethnic differences in cancer development, progression, and outcomes. In particular, the paucity of clinical
biospecimens from understudied populations, including Native Hawaiians, other Pacific Islanders, and Asian
Americans has limited the ability to address critical disparities in cancer risk and outcomes affecting these U.S.
communities. Hawaiʻi, the most ethnically diverse state in the nation, has experienced a higher burden of
common cancers-- including liver, breast, lung, colorectum, endometrium, and stomach, compared to the U.S
overall. Moreover, wide racial and ethnic disparities are observed within Hawaiʻi's uniquely diverse multiethnic
population including Native Hawaiians who have the highest mortality for breast, liver, lung, and other common
malignancies. The value of the biospecimens collected at the University of Hawaiʻi Cancer Center (UHCC) is
evident in the breadth and scope of its translational research. Despite this progress, biorepository efforts at the
UHCC to date have been fragmented and limited for certain types of specimens, especially fresh frozen tumor
tissue. Current UHCC biospecimen resources include a statewide repository of clinically-annotated, de-identified
archival formalin-fixed paraffin-embedded (FFPE) tumor tissue and prospectively and retrospectively collected
blood, urine, oral rinses, and stool from consented individuals. In contrast, the collection of fresh frozen tissue
has been largely limited to small scale collections for disparate investigator-initiated studies. There is a crucial
need at UHCC to standardize and centralize the collection of fresh frozen tumor and blood from cancer patients
in our participating community hospitals and to integrate these collections with existing resources in order to
optimize their utility for cancer research. We propose to develop a Pathology and Biospecimen Core that will
integrate and augment existing and new biospecimen resources with respect to their acquisition,
processing, tracking, storage, and distribution and will support Project 1 (NASH/liver cancer), Project 2 (lung
cancer), Project 3 (breast cancer), Career Enhancement Program (CEP) and Developmental Research Program
(DRP) projects, as well as other UHCC investigations with the goal of developing a robust infrastructure to
address differences in cancer risk and outcomes in Asian American, Native Hawaiian, and Pacific Islander
(AANHPI) ethnic minority populations. Aim 1 will focus on the development of a repository of paired fresh frozen
tumor tissue and blood specimens from multiethnic cancer cases diagnosed in the state of Hawaiʻi with cancers
of the lung, liver, breast, colorectum, endometrium, pancreas, and stomach. Potential cases will be identified via
rapid reporting from medical facilities statewide through the NCI SEER Hawaiʻi Tumor Registry. For Aim 2, we
will provide biospecimens from new and existing resources in support of Projects 1, 2, and 3, CEP and DRP
projects, and future cancer research projects.
摘要/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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BRENDA Y HERNANDEZ其他文献
BRENDA Y HERNANDEZ的其他文献
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{{ truncateString('BRENDA Y HERNANDEZ', 18)}}的其他基金
UHI COBRE: P1: MOL EPIDEMIOL & NATURAL HISTORY OF HPV IN HETEROSEXUAL MEN
UHI COBRE:P1:MOL 流行病
- 批准号:
8168408 - 财政年份:2010
- 资助金额:
$ 15.2万 - 项目类别:
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
完整项目 II:关岛肝癌的新危险因素和疾病关联
- 批准号:
10084113 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
完整项目 II:关岛肝癌的新危险因素和疾病关联
- 批准号:
10490855 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
(1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)
(1/2) 太平洋岛屿癌症健康公平伙伴关系 (PIPCHE)
- 批准号:
10266798 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
(1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)
(1/2) 太平洋岛屿癌症健康公平伙伴关系 (PIPCHE)
- 批准号:
10490850 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
完整项目 II:关岛肝癌的新危险因素和疾病关联
- 批准号:
10266801 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
(1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)
(1/2) 太平洋岛屿癌症健康公平伙伴关系 (PIPCHE)
- 批准号:
10084110 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
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