Core 3: Pathology & Biospecimens Core
核心 3:病理学
基本信息
- 批准号:10716159
- 负责人:
- 金额:$ 15.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-19 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAffectAsian AmericansAsian populationBiological Specimen BanksBloodBlood specimenBreastCancer BurdenCancer CenterCancer PatientCancer Research ProjectCellsCholine KinaseClinicalCohort StudiesCollectionColorectalColorectal CancerCommunitiesCommunity HospitalsCommunity ParticipationConsentCultural SensitivityDevelopmentDiagnosisDisparateEndometrial CarcinomaEndometriumEnsureEquityEthnic PopulationEtiologyExcess MortalityFecesFilipinoFormalinFoundationsFreezingFutureGoalsHawaiiHexokinase 2HumanImageIndividualInfrastructureInvestigationJapaneseJapanese AmericanLengthLiverLungMDM2 geneMalignant NeoplasmsMalignant neoplasm of liverMalignant neoplasm of lungMalignant neoplasm of pancreasMammary Gland ParenchymaMedicalMethylationMinority GroupsMinority Health ResearchMultiple MyelomaNative HawaiianNative Hawaiian or Other Pacific IslanderNot Hispanic or LatinoOralOral cavityOrganoidsOropharyngealOutcomePacific IslanderParaffin EmbeddingPathogenesisPathologyPathway interactionsPopulationPrimary carcinoma of the liver cellsProceduresProgram Research Project GrantsProtein KinaseReliability of ResultsReportingResearchResearch PersonnelResourcesSPHK1 enzymeSamoanSamplingSlideSomatomedinsSpecimenStandardizationStomachTP53 geneTestingTissuesTranslational ResearchTumor TissueUniversitiesUrineViral hepatitisanticancer researchbiobankcancer health disparitycancer riskcareerdiagnosis standardepidemiology studyethnic differenceethnic disparityethnic diversityethnic minorityethnic minority populationexperiencehuman subjectmalignant breast neoplasmmalignant stomach neoplasmmelanomaminimally invasiveminority communitiesminority health disparitymortalitymulti-ethnicnonalcoholic steatohepatitisprogramsprospectiveracial differenceracial disparityracial minorityracial minority populationrepositorysample collectiontelomeretranslational cancer researchtranslational potentialtumortumor registry
项目摘要
SUMMARY /ABSTRACT
Access to relevant biospecimens is critical to translational research on minority populations. The lack of
research specimens from racial and ethnic minority populations in the U.S. remains a barrier to understanding
racial/ethnic differences in cancer development, progression, and outcomes. In particular, the paucity of clinical
biospecimens from understudied populations, including Native Hawaiians, other Pacific Islanders, and Asian
Americans has limited the ability to address critical disparities in cancer risk and outcomes affecting these U.S.
communities. Hawaiʻi, the most ethnically diverse state in the nation, has experienced a higher burden of
common cancers-- including liver, breast, lung, colorectum, endometrium, and stomach, compared to the U.S
overall. Moreover, wide racial and ethnic disparities are observed within Hawaiʻi's uniquely diverse multiethnic
population including Native Hawaiians who have the highest mortality for breast, liver, lung, and other common
malignancies. The value of the biospecimens collected at the University of Hawaiʻi Cancer Center (UHCC) is
evident in the breadth and scope of its translational research. Despite this progress, biorepository efforts at the
UHCC to date have been fragmented and limited for certain types of specimens, especially fresh frozen tumor
tissue. Current UHCC biospecimen resources include a statewide repository of clinically-annotated, de-identified
archival formalin-fixed paraffin-embedded (FFPE) tumor tissue and prospectively and retrospectively collected
blood, urine, oral rinses, and stool from consented individuals. In contrast, the collection of fresh frozen tissue
has been largely limited to small scale collections for disparate investigator-initiated studies. There is a crucial
need at UHCC to standardize and centralize the collection of fresh frozen tumor and blood from cancer patients
in our participating community hospitals and to integrate these collections with existing resources in order to
optimize their utility for cancer research. We propose to develop a Pathology and Biospecimen Core that will
integrate and augment existing and new biospecimen resources with respect to their acquisition,
processing, tracking, storage, and distribution and will support Project 1 (NASH/liver cancer), Project 2 (lung
cancer), Project 3 (breast cancer), Career Enhancement Program (CEP) and Developmental Research Program
(DRP) projects, as well as other UHCC investigations with the goal of developing a robust infrastructure to
address differences in cancer risk and outcomes in Asian American, Native Hawaiian, and Pacific Islander
(AANHPI) ethnic minority populations. Aim 1 will focus on the development of a repository of paired fresh frozen
tumor tissue and blood specimens from multiethnic cancer cases diagnosed in the state of Hawaiʻi with cancers
of the lung, liver, breast, colorectum, endometrium, pancreas, and stomach. Potential cases will be identified via
rapid reporting from medical facilities statewide through the NCI SEER Hawaiʻi Tumor Registry. For Aim 2, we
will provide biospecimens from new and existing resources in support of Projects 1, 2, and 3, CEP and DRP
projects, and future cancer research projects.
摘要/摘要
获得相关的生物标本对于对少数群体进行翻译研究至关重要。缺乏
来自美国种族和少数民族人口的研究样本仍然是理解的障碍
在癌症的发展、进展和结果中的种族/民族差异。尤其是临床医生的匮乏
来自未被研究的种群的生物群落,包括夏威夷原住民、其他太平洋岛民和亚洲人
美国人在解决影响这些美国人的癌症风险和结果方面的严重差异的能力有限。
社区。夏威夷ʻI,美国种族最多元化的州,经历了更高的负担
与美国相比,常见的癌症--包括肝癌、乳腺癌、肺癌、结直肠癌、子宫内膜和胃癌
总体而言。此外,在夏威夷ʻI独特多样的多民族中观察到了广泛的种族和民族差异
包括乳房、肝脏、肺脏和其他常见疾病死亡率最高的夏威夷原住民
恶性肿瘤。在夏威夷大学ʻI癌症中心收集的生物标本的价值是
这在其翻译研究的广度和范围上是显而易见的。尽管取得了这一进展,但生物信息库的工作
到目前为止,对于某些类型的标本,特别是新鲜的冰冻肿瘤,UHCC是碎片化的和有限的。
组织。目前的UHCC生物样品资源包括全州范围的临床注释的、未识别的
前瞻性、回顾性收集福尔马林固定石蜡包埋(FFPE)肿瘤组织档案
个人同意的血液、尿液、口腔漱口水和粪便。相比之下,新鲜冰冻组织的收集
在很大程度上仅限于针对不同研究人员发起的研究的小规模收集。有一个至关重要的问题
UCC需要标准化和集中收集新鲜的冷冻肿瘤和癌症患者的血液
在我们参与的社区医院中,并将这些收藏与现有资源整合,以便
优化它们在癌症研究中的效用。我们建议开发一种病理学和生物质谱学核心,将
整合和增加现有和新的生物检疫资源,
加工、跟踪、储存和分发,并将支持项目1(NASH/肝癌)、项目2(肺癌
癌症)、项目3(乳腺癌)、职业提升方案(CEP)和发展研究方案
(DRP)项目,以及其他UCC调查,目的是开发强大的基础设施以
解决亚裔美国人、夏威夷原住民和太平洋岛民癌症风险和预后的差异
AANHPI)少数民族人口。目标1将专注于开发成对的新鲜冷冻库
夏威夷ʻI州确诊为癌症的多民族癌症患者的肿瘤组织和血液样本
肺、肝、乳房、结直肠、子宫内膜、胰腺和胃。潜在病例将通过以下途径确定
来自全州医疗机构的快速报告,通过NCI SEER HawaiʻI肿瘤登记处。对于目标2,我们
将从新的和现有的资源中提供生物检疫,以支持项目1、2和3、CEP和DRP
项目,以及未来的癌症研究项目。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
BRENDA Y HERNANDEZ其他文献
BRENDA Y HERNANDEZ的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('BRENDA Y HERNANDEZ', 18)}}的其他基金
UHI COBRE: P1: MOL EPIDEMIOL & NATURAL HISTORY OF HPV IN HETEROSEXUAL MEN
UHI COBRE:P1:MOL 流行病
- 批准号:
8168408 - 财政年份:2010
- 资助金额:
$ 15.2万 - 项目类别:
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
完整项目 II:关岛肝癌的新危险因素和疾病关联
- 批准号:
10084113 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
完整项目 II:关岛肝癌的新危险因素和疾病关联
- 批准号:
10490855 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
(1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)
(1/2) 太平洋岛屿癌症健康公平伙伴关系 (PIPCHE)
- 批准号:
10266798 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
(1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)
(1/2) 太平洋岛屿癌症健康公平伙伴关系 (PIPCHE)
- 批准号:
10490850 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
(1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)
(1/2) 太平洋岛屿癌症健康公平伙伴关系 (PIPCHE)
- 批准号:
10084110 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
完整项目 II:关岛肝癌的新危险因素和疾病关联
- 批准号:
10266801 - 财政年份:2009
- 资助金额:
$ 15.2万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 15.2万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 15.2万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 15.2万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 15.2万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 15.2万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 15.2万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 15.2万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 15.2万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 15.2万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 15.2万 - 项目类别:
Studentship