Core 3: Pathology & Biospecimens Core

核心 3：病理学

• 批准号: 10716159
• 负责人: BRENDA Y HERNANDEZ
• 金额: $ 15.2万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10716159
• 关键词: Address; Affect; Asian Americans; Asian population; Biological Specimen Banks; Blood; Blood specimen; Breast; Cancer Burden; Cancer Center; Cancer Patient; Cancer Research Project; Cells; Choline Kinase; Clinical; Cohort Studies; Collection; Colorectal; Colorectal Cancer; Communities; Community Hospitals; Community Participation; Consent; Cultural Sensitivity; Development; Diagnosis; Disparate; Endometrial Carcinoma; Endometrium; Ensure; Equity; Ethnic Population; Etiology; Excess Mortality; Feces; Filipino; Formalin; Foundations; Freezing; Future; Goals; Hawaii; Hexokinase 2; Human; Image; Individual; Infrastructure; Investigation; Japanese; Japanese American; Length; Liver; Lung; MDM2 gene; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Mammary Gland Parenchyma; Medical; Methylation; Minority Groups; Minority Health Research; Multiple Myeloma; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Not Hispanic or Latino; Oral; Oral cavity; Organoids; Oropharyngeal; Outcome; Pacific Islander; Paraffin Embedding; Pathogenesis; Pathology; Pathway interactions; Population; Primary carcinoma of the liver cells; Procedures; Program Research Project Grants; Protein Kinase; Reliability of Results; Reporting; Research; Research Personnel; Resources; SPHK1 enzyme; Samoan; Sampling; Slide; Somatomedins; Specimen; Standardization; Stomach; TP53 gene; Testing; Tissues; Translational Research; Tumor Tissue; Universities; Urine; Viral hepatitis; anticancer research; biobank; cancer health disparity; cancer risk; career; diagnosis standard; epidemiology study; ethnic difference; ethnic disparity; ethnic diversity; ethnic minority; ethnic minority population; experience; human subject; malignant breast neoplasm; malignant stomach neoplasm; melanoma; minimally invasive; minority communities; minority health disparity; mortality; multi-ethnic; nonalcoholic steatohepatitis; programs; prospective; racial difference; racial disparity; racial minority; racial minority population; repository; sample collection; telomere; translational cancer research; translational potential; tumor; tumor registry

SUMMARY /ABSTRACT Access to relevant biospecimens is critical to translational research on minority populations. The lack of research specimens from racial and ethnic minority populations in the U.S. remains a barrier to understanding racial/ethnic differences in cancer development, progression, and outcomes. In particular, the paucity of clinical biospecimens from understudied populations, including Native Hawaiians, other Pacific Islanders, and Asian Americans has limited the ability to address critical disparities in cancer risk and outcomes affecting these U.S. communities. Hawaiʻi, the most ethnically diverse state in the nation, has experienced a higher burden of common cancers-- including liver, breast, lung, colorectum, endometrium, and stomach, compared to the U.S overall. Moreover, wide racial and ethnic disparities are observed within Hawaiʻi's uniquely diverse multiethnic population including Native Hawaiians who have the highest mortality for breast, liver, lung, and other common malignancies. The value of the biospecimens collected at the University of Hawaiʻi Cancer Center (UHCC) is evident in the breadth and scope of its translational research. Despite this progress, biorepository efforts at the UHCC to date have been fragmented and limited for certain types of specimens, especially fresh frozen tumor tissue. Current UHCC biospecimen resources include a statewide repository of clinically-annotated, de-identified archival formalin-fixed paraffin-embedded (FFPE) tumor tissue and prospectively and retrospectively collected blood, urine, oral rinses, and stool from consented individuals. In contrast, the collection of fresh frozen tissue has been largely limited to small scale collections for disparate investigator-initiated studies. There is a crucial need at UHCC to standardize and centralize the collection of fresh frozen tumor and blood from cancer patients in our participating community hospitals and to integrate these collections with existing resources in order to optimize their utility for cancer research. We propose to develop a Pathology and Biospecimen Core that will integrate and augment existing and new biospecimen resources with respect to their acquisition, processing, tracking, storage, and distribution and will support Project 1 (NASH/liver cancer), Project 2 (lung cancer), Project 3 (breast cancer), Career Enhancement Program (CEP) and Developmental Research Program (DRP) projects, as well as other UHCC investigations with the goal of developing a robust infrastructure to address differences in cancer risk and outcomes in Asian American, Native Hawaiian, and Pacific Islander (AANHPI) ethnic minority populations. Aim 1 will focus on the development of a repository of paired fresh frozen tumor tissue and blood specimens from multiethnic cancer cases diagnosed in the state of Hawaiʻi with cancers of the lung, liver, breast, colorectum, endometrium, pancreas, and stomach. Potential cases will be identified via rapid reporting from medical facilities statewide through the NCI SEER Hawaiʻi Tumor Registry. For Aim 2, we will provide biospecimens from new and existing resources in support of Projects 1, 2, and 3, CEP and DRP projects, and future cancer research projects.

摘要 /摘要 获取相关的生物测量对于翻译少数民族人群的研究至关重要。缺乏 美国种族和少数民族人口的研究标本仍然是理解的障碍 癌症发展，发展和结果的种族/种族差异。特别是临床缺乏 来自夏威夷人，其他太平洋岛民和亚洲人在内的知识人群的生物测量 美国人限制了解决癌症风险的关键差异和影响这些美国的关键差异的能力 社区。夏威夷是全国最多样化的国家，经历了更高的燃烧 与美国相比 全面的。此外，在夏威夷独特的潜水员多民族中观察到广泛的种族和种族差异 包括乳房，肝，肺和其他常见死亡率最高的夏威夷人的人口 恶性肿瘤。在夏威夷大学癌症中心（UHCC）收集的生物测量的价值是 其转化研究的广度和范围的证据。尽管取得了这种进展，但生物座席还是在 迄今为止的UHCC已被分散且针对某些类型的规格有限，尤其是新鲜的冷冻肿瘤 组织。当前的UHCC生物循环资源包括全州范围内的临床通道的存储库 档案福尔马林固定石蜡包裹（FFPE）肿瘤组织，并进行回顾性收集 同意个体的血液，尿液，口腔冲洗和粪便。相反，收集新鲜冷冻组织 在很大程度上仅限于小规模收集，用于不同的研究者引发的研究。有关键 在UHCC需要标准化和集中癌症患者新鲜冷冻肿瘤和血液的收集 在我们参与的社区医院，并将这些收藏与现有资源融合在一起，以便 优化其用于癌症研究的效用。我们建议开发一种病理和生物循环核心 关于收购的综合和增强现有和新的生物测量资源， 处理，跟踪，存储和分发，并将支持项目1（NASH/肝癌），项目2（肺癌） 癌症），项目3（乳腺癌），职业增强计划（CEP）和发展研究计划 （DRP）项目以及其他UHCC投资，目的是开发强大的基础架构 解决亚裔美国人，夏威夷原住民和太平洋岛民的癌症风险和结果的差异 （AANHPI）少数民族人口。 AIM 1将重点放在配对新鲜冷冻的存储库中 来自夏威夷诊断出的多种族癌症病例的肿瘤组织和血液标本 潜在案例将通过 通过NCI SEER夏威夷肿瘤注册中心从全州范围内的医疗机构进行快速报道。对于目标2，我们 将提供来自新资源和现有资源的生物测量，以支持项目1、2和3，CEP和DRP 项目和未来的癌症研究项目。