Core 3: Pathology & Biospecimens Core

核心 3:病理学

基本信息

  • 批准号:
    10716159
  • 负责人:
  • 金额:
    $ 15.2万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-19 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

SUMMARY /ABSTRACT Access to relevant biospecimens is critical to translational research on minority populations. The lack of research specimens from racial and ethnic minority populations in the U.S. remains a barrier to understanding racial/ethnic differences in cancer development, progression, and outcomes. In particular, the paucity of clinical biospecimens from understudied populations, including Native Hawaiians, other Pacific Islanders, and Asian Americans has limited the ability to address critical disparities in cancer risk and outcomes affecting these U.S. communities. Hawaiʻi, the most ethnically diverse state in the nation, has experienced a higher burden of common cancers-- including liver, breast, lung, colorectum, endometrium, and stomach, compared to the U.S overall. Moreover, wide racial and ethnic disparities are observed within Hawaiʻi's uniquely diverse multiethnic population including Native Hawaiians who have the highest mortality for breast, liver, lung, and other common malignancies. The value of the biospecimens collected at the University of Hawaiʻi Cancer Center (UHCC) is evident in the breadth and scope of its translational research. Despite this progress, biorepository efforts at the UHCC to date have been fragmented and limited for certain types of specimens, especially fresh frozen tumor tissue. Current UHCC biospecimen resources include a statewide repository of clinically-annotated, de-identified archival formalin-fixed paraffin-embedded (FFPE) tumor tissue and prospectively and retrospectively collected blood, urine, oral rinses, and stool from consented individuals. In contrast, the collection of fresh frozen tissue has been largely limited to small scale collections for disparate investigator-initiated studies. There is a crucial need at UHCC to standardize and centralize the collection of fresh frozen tumor and blood from cancer patients in our participating community hospitals and to integrate these collections with existing resources in order to optimize their utility for cancer research. We propose to develop a Pathology and Biospecimen Core that will integrate and augment existing and new biospecimen resources with respect to their acquisition, processing, tracking, storage, and distribution and will support Project 1 (NASH/liver cancer), Project 2 (lung cancer), Project 3 (breast cancer), Career Enhancement Program (CEP) and Developmental Research Program (DRP) projects, as well as other UHCC investigations with the goal of developing a robust infrastructure to address differences in cancer risk and outcomes in Asian American, Native Hawaiian, and Pacific Islander (AANHPI) ethnic minority populations. Aim 1 will focus on the development of a repository of paired fresh frozen tumor tissue and blood specimens from multiethnic cancer cases diagnosed in the state of Hawaiʻi with cancers of the lung, liver, breast, colorectum, endometrium, pancreas, and stomach. Potential cases will be identified via rapid reporting from medical facilities statewide through the NCI SEER Hawaiʻi Tumor Registry. For Aim 2, we will provide biospecimens from new and existing resources in support of Projects 1, 2, and 3, CEP and DRP projects, and future cancer research projects.
总结/摘要 获取相关生物标本对于少数群体转化研究至关重要。缺乏 来自美国种族和少数民族的研究标本仍然是理解的障碍 癌症发展、进展和结局的种族/民族差异。特别是,缺乏临床 来自未充分研究的人群的生物标本,包括夏威夷原住民,其他太平洋岛民和亚洲人。 美国人解决影响这些美国人的癌症风险和结果的关键差异的能力有限。 社区.夏威夷是美国种族最多样化的州, 常见的癌症--包括肝癌、乳腺癌、肺癌、结肠直肠癌、子宫内膜癌和胃癌,与美国相比, 总的来说。此外,在夏威夷独特的多民族多元社会中, 包括夏威夷原住民在内的人口中,乳腺癌、肝、肺和其他常见疾病的死亡率最高。 恶性肿瘤。在夏威夷大学癌症中心(UHCC)收集的生物标本的价值是 这在其翻译研究的广度和范围上显而易见。尽管取得了这一进展, 迄今为止,UHCC已被破碎,并限于某些类型的标本,特别是新鲜冷冻肿瘤 组织.目前的UHCC生物标本资源包括全州范围内的临床注释,去识别的 存档福尔马林固定石蜡包埋(FFPE)肿瘤组织,并前瞻性和回顾性收集 血液、尿液、口腔冲洗液和粪便。相比之下,收集新鲜冷冻组织 在很大程度上限于小规模收集不同的制药商发起的研究。有一个至关重要的 UHCC需要标准化和集中收集癌症患者的新鲜冷冻肿瘤和血液 在我们参与的社区医院,并将这些收集与现有资源相结合, 优化它们在癌症研究中的效用。我们建议开发病理学和生物标本核心, 整合和增加现有的和新的生物标本资源, 处理、跟踪、储存和分发,并将支持项目1(NASH/肝癌)、项目2(肺癌)、项目3(非酒精性脂肪性肝炎)和项目4(肺癌)。 癌症),项目3(乳腺癌),职业提升计划(CEP)和发展研究计划 (DRP)项目,以及其他UHCC调查,目标是开发一个强大的基础设施, 解决亚裔美国人、夏威夷原住民和太平洋岛民的癌症风险和结局差异 (AANHPI)少数民族人口。目标1将集中于发展一个成对的新鲜冷冻 肿瘤组织和血液样本来自夏威夷州诊断为癌症的多种族癌症病例 肺、肝、乳腺、结肠直肠、子宫内膜、胰腺和胃。将通过以下方式确定潜在病例: 通过NCI SEER夏威夷肿瘤登记处从全州医疗机构快速报告。对于目标2, 将从新的和现有的资源中提供生物标本,以支持项目1、2和3、CEP和DRP 未来的癌症研究项目。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

BRENDA Y HERNANDEZ其他文献

BRENDA Y HERNANDEZ的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('BRENDA Y HERNANDEZ', 18)}}的其他基金

UHI COBRE: P1: MOL EPIDEMIOL & NATURAL HISTORY OF HPV IN HETEROSEXUAL MEN
UHI COBRE:P1:MOL 流行病
  • 批准号:
    8168408
  • 财政年份:
    2010
  • 资助金额:
    $ 15.2万
  • 项目类别:
Core II: Cancer Registry Core
核心 II:癌症登记核心
  • 批准号:
    10490863
  • 财政年份:
    2009
  • 资助金额:
    $ 15.2万
  • 项目类别:
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
完整项目 II:关岛肝癌的新危险因素和疾病关联
  • 批准号:
    10084113
  • 财政年份:
    2009
  • 资助金额:
    $ 15.2万
  • 项目类别:
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
完整项目 II:关岛肝癌的新危险因素和疾病关联
  • 批准号:
    10490855
  • 财政年份:
    2009
  • 资助金额:
    $ 15.2万
  • 项目类别:
Core II: Cancer Registry Core
核心 II:癌症登记核心
  • 批准号:
    10266806
  • 财政年份:
    2009
  • 资助金额:
    $ 15.2万
  • 项目类别:
(1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)
(1/2) 太平洋岛屿癌症健康公平伙伴关系 (PIPCHE)
  • 批准号:
    10266798
  • 财政年份:
    2009
  • 资助金额:
    $ 15.2万
  • 项目类别:
(1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)
(1/2) 太平洋岛屿癌症健康公平伙伴关系 (PIPCHE)
  • 批准号:
    10490850
  • 财政年份:
    2009
  • 资助金额:
    $ 15.2万
  • 项目类别:
Full Project II: Novel Risk Factors and Disease Associations of Liver Cancer in Guam
完整项目 II:关岛肝癌的新危险因素和疾病关联
  • 批准号:
    10266801
  • 财政年份:
    2009
  • 资助金额:
    $ 15.2万
  • 项目类别:
(1/2) Pacific Island Partnership for Cancer Health Equity (PIPCHE)
(1/2) 太平洋岛屿癌症健康公平伙伴关系 (PIPCHE)
  • 批准号:
    10084110
  • 财政年份:
    2009
  • 资助金额:
    $ 15.2万
  • 项目类别:
Core II: Cancer Registry Core
核心 II:癌症登记核心
  • 批准号:
    10084119
  • 财政年份:
    2009
  • 资助金额:
    $ 15.2万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 15.2万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了