Core 3: Pathology & Biospecimens Core

核心 3：病理学

• 批准号: 10716159
• 负责人: BRENDA Y HERNANDEZ
• 金额: $ 15.2万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10716159
• 关键词: Address; Affect; Asian Americans; Asian population; Biological Specimen Banks; Blood; Blood specimen; Breast; Cancer Burden; Cancer Center; Cancer Patient; Cancer Research Project; Cells; Choline Kinase; Clinical; Cohort Studies; Collection; Colorectal; Colorectal Cancer; Communities; Community Hospitals; Community Participation; Consent; Cultural Sensitivity; Development; Diagnosis; Disparate; Endometrial Carcinoma; Endometrium; Ensure; Equity; Ethnic Population; Etiology; Excess Mortality; Feces; Filipino; Formalin; Foundations; Freezing; Future; Goals; Hawaii; Hexokinase 2; Human; Image; Individual; Infrastructure; Investigation; Japanese; Japanese American; Length; Liver; Lung; MDM2 gene; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Mammary Gland Parenchyma; Medical; Methylation; Minority Groups; Minority Health Research; Multiple Myeloma; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Not Hispanic or Latino; Oral; Oral cavity; Organoids; Oropharyngeal; Outcome; Pacific Islander; Paraffin Embedding; Pathogenesis; Pathology; Pathway interactions; Population; Primary carcinoma of the liver cells; Procedures; Program Research Project Grants; Protein Kinase; Reliability of Results; Reporting; Research; Research Personnel; Resources; SPHK1 enzyme; Samoan; Sampling; Slide; Somatomedins; Specimen; Standardization; Stomach; TP53 gene; Testing; Tissues; Translational Research; Tumor Tissue; Universities; Urine; Viral hepatitis; anticancer research; biobank; cancer health disparity; cancer risk; career; diagnosis standard; epidemiology study; ethnic difference; ethnic disparity; ethnic diversity; ethnic minority; ethnic minority population; experience; human subject; malignant breast neoplasm; malignant stomach neoplasm; melanoma; minimally invasive; minority communities; minority health disparity; mortality; multi-ethnic; nonalcoholic steatohepatitis; programs; prospective; racial difference; racial disparity; racial minority; racial minority population; repository; sample collection; telomere; translational cancer research; translational potential; tumor; tumor registry

SUMMARY /ABSTRACT Access to relevant biospecimens is critical to translational research on minority populations. The lack of research specimens from racial and ethnic minority populations in the U.S. remains a barrier to understanding racial/ethnic differences in cancer development, progression, and outcomes. In particular, the paucity of clinical biospecimens from understudied populations, including Native Hawaiians, other Pacific Islanders, and Asian Americans has limited the ability to address critical disparities in cancer risk and outcomes affecting these U.S. communities. Hawaiʻi, the most ethnically diverse state in the nation, has experienced a higher burden of common cancers-- including liver, breast, lung, colorectum, endometrium, and stomach, compared to the U.S overall. Moreover, wide racial and ethnic disparities are observed within Hawaiʻi's uniquely diverse multiethnic population including Native Hawaiians who have the highest mortality for breast, liver, lung, and other common malignancies. The value of the biospecimens collected at the University of Hawaiʻi Cancer Center (UHCC) is evident in the breadth and scope of its translational research. Despite this progress, biorepository efforts at the UHCC to date have been fragmented and limited for certain types of specimens, especially fresh frozen tumor tissue. Current UHCC biospecimen resources include a statewide repository of clinically-annotated, de-identified archival formalin-fixed paraffin-embedded (FFPE) tumor tissue and prospectively and retrospectively collected blood, urine, oral rinses, and stool from consented individuals. In contrast, the collection of fresh frozen tissue has been largely limited to small scale collections for disparate investigator-initiated studies. There is a crucial need at UHCC to standardize and centralize the collection of fresh frozen tumor and blood from cancer patients in our participating community hospitals and to integrate these collections with existing resources in order to optimize their utility for cancer research. We propose to develop a Pathology and Biospecimen Core that will integrate and augment existing and new biospecimen resources with respect to their acquisition, processing, tracking, storage, and distribution and will support Project 1 (NASH/liver cancer), Project 2 (lung cancer), Project 3 (breast cancer), Career Enhancement Program (CEP) and Developmental Research Program (DRP) projects, as well as other UHCC investigations with the goal of developing a robust infrastructure to address differences in cancer risk and outcomes in Asian American, Native Hawaiian, and Pacific Islander (AANHPI) ethnic minority populations. Aim 1 will focus on the development of a repository of paired fresh frozen tumor tissue and blood specimens from multiethnic cancer cases diagnosed in the state of Hawaiʻi with cancers of the lung, liver, breast, colorectum, endometrium, pancreas, and stomach. Potential cases will be identified via rapid reporting from medical facilities statewide through the NCI SEER Hawaiʻi Tumor Registry. For Aim 2, we will provide biospecimens from new and existing resources in support of Projects 1, 2, and 3, CEP and DRP projects, and future cancer research projects.

摘要/摘要 获得相关的生物标本对于对少数群体进行翻译研究至关重要。缺乏 来自美国种族和少数民族人口的研究样本仍然是理解的障碍 在癌症的发展、进展和结果中的种族/民族差异。尤其是临床医生的匮乏 来自未被研究的种群的生物群落，包括夏威夷原住民、其他太平洋岛民和亚洲人 美国人在解决影响这些美国人的癌症风险和结果方面的严重差异的能力有限。 社区。夏威夷ʻI，美国种族最多元化的州，经历了更高的负担 与美国相比，常见的癌症--包括肝癌、乳腺癌、肺癌、结直肠癌、子宫内膜和胃癌 总体而言。此外，在夏威夷ʻI独特多样的多民族中观察到了广泛的种族和民族差异 包括乳房、肝脏、肺脏和其他常见疾病死亡率最高的夏威夷原住民 恶性肿瘤。在夏威夷大学ʻI癌症中心收集的生物标本的价值是 这在其翻译研究的广度和范围上是显而易见的。尽管取得了这一进展，但生物信息库的工作 到目前为止，对于某些类型的标本，特别是新鲜的冰冻肿瘤，UHCC是碎片化的和有限的。 组织。目前的UHCC生物样品资源包括全州范围的临床注释的、未识别的 前瞻性、回顾性收集福尔马林固定石蜡包埋(FFPE)肿瘤组织档案 个人同意的血液、尿液、口腔漱口水和粪便。相比之下，新鲜冰冻组织的收集 在很大程度上仅限于针对不同研究人员发起的研究的小规模收集。有一个至关重要的问题 UCC需要标准化和集中收集新鲜的冷冻肿瘤和癌症患者的血液 在我们参与的社区医院中，并将这些收藏与现有资源整合，以便 优化它们在癌症研究中的效用。我们建议开发一种病理学和生物质谱学核心，将 整合和增加现有和新的生物检疫资源， 加工、跟踪、储存和分发，并将支持项目1(NASH/肝癌)、项目2(肺癌 癌症)、项目3(乳腺癌)、职业提升方案(CEP)和发展研究方案 (DRP)项目，以及其他UCC调查，目的是开发强大的基础设施以 解决亚裔美国人、夏威夷原住民和太平洋岛民癌症风险和预后的差异 AANHPI)少数民族人口。目标1将专注于开发成对的新鲜冷冻库 夏威夷ʻI州确诊为癌症的多民族癌症患者的肿瘤组织和血液样本 肺、肝、乳房、结直肠、子宫内膜、胰腺和胃。潜在病例将通过以下途径确定 来自全州医疗机构的快速报告，通过NCI SEER HawaiʻI肿瘤登记处。对于目标2，我们 将从新的和现有的资源中提供生物检疫，以支持项目1、2和3、CEP和DRP 项目，以及未来的癌症研究项目。