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Core 3: Pathology & Biospecimens Core

核心 3：病理学

基本信息

批准号：
10716159
负责人：
BRENDA Y HERNANDEZ
金额：
$ 15.2万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-19 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10716159
关键词：
Address Affect Asian Americans Asian population Biological Specimen Banks Blood Blood specimen Breast Cancer Burden Cancer Center Cancer Patient Cancer Research Project Cells Choline Kinase Clinical Cohort Studies Collection Colorectal Colorectal Cancer Communities Community Hospitals Community Participation Consent Cultural Sensitivity Development Diagnosis Disparate Endometrial Carcinoma Endometrium Ensure Equity Ethnic Population Etiology Excess Mortality Feces Filipino Formalin Foundations Freezing Future Goals Hawaii Hexokinase 2 Human Image Individual Infrastructure Investigation Japanese Japanese American Length Liver Lung MDM2 gene Malignant Neoplasms Malignant neoplasm of liver Malignant neoplasm of lung Malignant neoplasm of pancreas Mammary Gland Parenchyma Medical Methylation Minority Groups Minority Health Research Multiple Myeloma Native Hawaiian Native Hawaiian or Other Pacific Islander Not Hispanic or Latino Oral Oral cavity Organoids Oropharyngeal Outcome Pacific Islander Paraffin Embedding Pathogenesis Pathology Pathway interactions Population Primary carcinoma of the liver cells Procedures Program Research Project Grants Protein Kinase Reliability of Results Reporting Research Research Personnel Resources SPHK1 enzyme Samoan Sampling Slide Somatomedins Specimen Standardization Stomach TP53 gene Testing Tissues Translational Research Tumor Tissue Universities Urine Viral hepatitis anticancer research biobank cancer health disparity cancer risk career diagnosis standard epidemiology study ethnic difference ethnic disparity ethnic diversity ethnic minority ethnic minority population experience human subject malignant breast neoplasm malignant stomach neoplasm melanoma minimally invasive minority communities minority health disparity mortality multi-ethnic nonalcoholic steatohepatitis programs prospective racial difference racial disparity racial minority racial minority population repository sample collection telomere translational cancer research translational potential tumor tumor registry

项目摘要

SUMMARY /ABSTRACT Access to relevant biospecimens is critical to translational research on minority populations. The lack of research specimens from racial and ethnic minority populations in the U.S. remains a barrier to understanding racial/ethnic differences in cancer development, progression, and outcomes. In particular, the paucity of clinical biospecimens from understudied populations, including Native Hawaiians, other Pacific Islanders, and Asian Americans has limited the ability to address critical disparities in cancer risk and outcomes affecting these U.S. communities. Hawaiʻi, the most ethnically diverse state in the nation, has experienced a higher burden of common cancers-- including liver, breast, lung, colorectum, endometrium, and stomach, compared to the U.S overall. Moreover, wide racial and ethnic disparities are observed within Hawaiʻi's uniquely diverse multiethnic population including Native Hawaiians who have the highest mortality for breast, liver, lung, and other common malignancies. The value of the biospecimens collected at the University of Hawaiʻi Cancer Center (UHCC) is evident in the breadth and scope of its translational research. Despite this progress, biorepository efforts at the UHCC to date have been fragmented and limited for certain types of specimens, especially fresh frozen tumor tissue. Current UHCC biospecimen resources include a statewide repository of clinically-annotated, de-identified archival formalin-fixed paraffin-embedded (FFPE) tumor tissue and prospectively and retrospectively collected blood, urine, oral rinses, and stool from consented individuals. In contrast, the collection of fresh frozen tissue has been largely limited to small scale collections for disparate investigator-initiated studies. There is a crucial need at UHCC to standardize and centralize the collection of fresh frozen tumor and blood from cancer patients in our participating community hospitals and to integrate these collections with existing resources in order to optimize their utility for cancer research. We propose to develop a Pathology and Biospecimen Core that will integrate and augment existing and new biospecimen resources with respect to their acquisition, processing, tracking, storage, and distribution and will support Project 1 (NASH/liver cancer), Project 2 (lung cancer), Project 3 (breast cancer), Career Enhancement Program (CEP) and Developmental Research Program (DRP) projects, as well as other UHCC investigations with the goal of developing a robust infrastructure to address differences in cancer risk and outcomes in Asian American, Native Hawaiian, and Pacific Islander (AANHPI) ethnic minority populations. Aim 1 will focus on the development of a repository of paired fresh frozen tumor tissue and blood specimens from multiethnic cancer cases diagnosed in the state of Hawaiʻi with cancers of the lung, liver, breast, colorectum, endometrium, pancreas, and stomach. Potential cases will be identified via rapid reporting from medical facilities statewide through the NCI SEER Hawaiʻi Tumor Registry. For Aim 2, we will provide biospecimens from new and existing resources in support of Projects 1, 2, and 3, CEP and DRP projects, and future cancer research projects.

摘要/文摘