Center Core Grant for Vision Research

项目总结：整体中心核心 视力研究中心核心助学金的首要目标是支持、加强和扩大 南加州大学的基础和翻译视觉科学研究。中心核心将 为28名优秀调查人员提供共享资源，致力于澄清 眼科疾病的发病机制、诊断和治疗。目前，这些参与调查的人员 累计持有NIH资助的28项研究资助，其中包括来自NEI的21项资助(13个R01，1个R21，7个K- 来自其他机构的7项资助(4项R01，1项R21，1项RF1，1项K08)。中心核心将支持3个 高度集成的资源核心：1)眼科治疗工程核心，2)细胞和组织成像 和数据科学核心，3)动物模型和活体成像核心。这些核心将提供卓越的 设施、仪器和专门知识是加强和扩大研究的必要资源 参与调查人员的计划，帮助老牌调查人员在新出现的领域进行研究 并协助新的研究人员开发视觉研究项目。中心核心还将 协调和整合核心活动，促进创新新兴技术的应用，促进 协作的跨学科视觉研究。中心核心将作为开展 有影响力的基础和翻译视觉研究侧重于促进生物学知识和 视觉系统的病理生理学和新的诊断和治疗方法的发展 视力受损。

PROJECT SUMMARY: OVERALL CENTER CORE The overarching goal of the Center Core Grant for Vision Research is to support, strengthen and broaden basic and translational vision science research at the University of Southern California. The Center Core will provide shared resources accessible to a group of 28 outstanding investigators, dedicated to elucidating mechanisms, diagnosis, and treatment of ocular diseases. Currently, these participating investigators cumulatively hold 28 NIH-funded research grants, consisting of 21 grants from NEI (13 R01s, 1 R21, 7 K- awards) and 7 grants from other institutes (4 R01s, 1 R21, 1 RF1, 1 K08). The Center Core will support 3 highly integrated Resource Cores: 1) Ophthalmic Therapeutics Engineering Core, 2) Cell & Tissue Imaging and Data Science Core, 3) Animal Models and In Vivo Imaging Core. These Cores will offer exceptional facilities, instrumentation and expertise that are essential resources to enhance and expand the research programs of participating investigators, aid established investigators in pursuing research in new emerging fields, and assist new investigators in developing vision research projects. The Center Core will also coordinate and integrate Core activities, promote utilization of innovative emerging technologies, and facilitate collaborative inter-disciplinary vision research. The Center Core will serve as a cornerstone for conduct of impactful basic and translational vision research focused on advancing knowledge of the biology and pathophysiology of the visual system and development of novel diagnostic and therapeutic approaches for vision impairment.