Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote West

项目摘要/摘要 INBRE的这一行政补充扩大了爱达荷州进行妇女健康研究的能力。 这项拟议的研究属于母公司INBRE奖(P20 GM103408)的范围。该项目符合以下要求 爱达荷州INBRE广泛而包容的科学主题--细胞信号传递--发展了研究人员的研究 能力，并为学生提供研究机会。精神、认知和情感上的妥协 美国妇女在围产期和生活在农村边远地区的妇女中，健康是很常见的 西方受到的影响不成比例。这些健康疾病高患病率背后的因素 女性是复杂的，但糟糕的饮食是一个可疑的、突出的因素。我们提出了一个纵向的， 对居住在爱达荷州、蒙大拿州和怀俄明州的围产期妇女进行重复测量的观察性研究。我们会 检验以下假设：1)农村边远地区和西部边远地区妇女的围产期饮食模式不同 关键的人口统计变量(例如，家庭收入)和2)消费特定饮食模式的妇女 与其他类型的饮用者相比，更好的精神、认知和情绪健康评估 节食。这些假设将在两个具体目标上得到检验。第一个目标将使用经过验证的工具来表征 研究对象的急性和慢性围产期饮食模式，并确定这些模式的变异是否 与家庭收入和其他关键人口统计数据有关。第二个目标将使用严格的方法来 记录饮食模式与围产期母亲心理健康、认知功能和 情感上的幸福。确定与更好的产妇神经健康相关的饮食模式是 设计干预措施的第一步，以促进积极的行为改变和改善产前护理。因此， 这项研究将为未来研究的设计和样本量计算提供基础数据。 这项研究还将增加接受女性健康相关生物医学培训的学生数量 并为R01提案提供初步数据。我们研究计划的长期目标是 实施营养教育干预措施，促进积极的饮食和行为改变，并最终 改善生活在农村边疆和偏远西部的妇女的营养和神经健康。

Project Summary/Abstract This INBRE administrative supplement expands the capacity of Idaho to conduct women’s health research. The proposed research is within the scope of the parent INBRE award (P20 GM103408). The project fits within the broad and inclusive Idaho INBRE scientific theme of ‘cell signaling,’ develops investigator research capacity, and provides research opportunities to students. Compromised mental, cognitive, and emotional health is common in US women during the perinatal period, and those living in the rural frontier and remote West are disproportionately affected. Factors underlying the high prevalence of these health disorders in women are complex, but poor diet is a suspected, prominent contributing factor. We propose a longitudinal, repeated-measured, observational study of perinatal women living in Idaho, Montana, and Wyoming. We will test the hypotheses that 1) perinatal dietary patterns of women in the rural frontier and remote West vary by key demographic variables (e.g., household income) and 2) women consuming certain dietary patterns have better mental, cognitive, and emotional wellbeing assessments compared to those consuming other types of diets. These hypotheses will be tested in two specific aims. The first aim will use validated tools to characterize acute and chronic perinatal dietary patterns of the study subjects and determine if variation in these patterns is related to household income and other key demographics. The second aim will use rigorous methodologies to document associations between dietary patterns and perinatal maternal mental health, cognitive function, and emotional wellbeing. Identification of dietary patterns associated with better maternal neurological health is the first step in designing interventions to facilitate positive behavior changes and improve prenatal care. As such, this study will provide foundational data to inform the design of and sample size calculations for future studies. This study will also increase the number of students with training in women’s health-related biomedical sciences and provide preliminary data for an R01 proposal. The long-term goal of our research program is to implement nutrition education interventions to facilitate positive dietary and behavior changes and ultimately improve nutritional and neurological health of women living in the rural frontier and remote West.