Psychobiological Mechanisms of Behavioral Dysregulation

行为失调的心理生物学机制

• 批准号: 7137921
• 负责人: james r blair
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7137921
• 关键词: amygdala; antisocial personality; behavior disorders; behavioral /social science research tag; brain mapping; frontal lobe /cortex; functional magnetic resonance imaging; human subject; neuroimaging; neuropathology; neuropsychology; psychobiology; psychopathology; social behavior disorders

This project investigates the emotional deficits that can give rise to extreme behavioral disturbance; high levels of instrumental antisocial behavior coupled with an absence of expressed guilt/ remorse. Currently, there are two main positions regarding the neural systems that are dysfunctional in such individuals: First, that the pathology is associated with amygdala dysfunction; Secondly, that the pathology is associated with orbital frontal cortex dysfunction. Identification of the neuro-biological underpinnings of their emotional dysfunction is of crucial importance as the level of emotion dysfunction is an important predictor of long term prognosis. The current project determines the performance of individuals with extreme behavioral disturbance and comparison individuals on measures which recruit the amygdala and orbital frontal cortex. In addition, a series of functional neuro-imaging studies will directly assess neural responses in these two systems in these individuals. Finally, a structural imaging study will examine anatomical differences between the groups. The project should provide clear data that will constrain future theorizing on the pathology implicated in this disorder.

这个项目调查了可能导致极端行为障碍的情绪缺陷；高水平的工具性反社会行为，加上没有表现出内疚/悔恨。目前，关于这类个体神经系统功能障碍的主要观点有两种：第一，病理与杏仁核功能障碍有关；第二，病理与眼眶额叶皮质功能障碍有关。确定他们情绪障碍的神经生物学基础是至关重要的，因为情绪障碍的程度是长期预后的重要预测指标。 目前的项目确定了有极端行为障碍的个体的表现，并比较了招募杏仁核和眼眶额叶皮质的个体。此外，一系列功能神经成像研究将直接评估这些个体在这两个系统中的神经反应。最后，结构成像研究将检查两组之间的解剖差异。该项目应该提供明确的数据，这些数据将限制未来对这种疾病所涉及的病理进行理论推导。