Developing And Improving Institutional Animal Resources

描述（由申请人提供）： 在过去的七年里，洛杉矶儿童医院（CHLA）的萨班研究所（TSRI）在多个层面上都经历了大幅增长。研究人员的招聘增加了146%，校外研究资金几乎翻了一番，NIH的资金增加了一倍多，捐赠增加了250%，空间增加了160%，2003年6月完成了一个新的研究设施，萨班研究大楼是一个新的国家的最先进的动物护理设施（ACF）的家。因此，ACF中的啮齿动物数量在过去3年中翻了一番。该设施配备了小型啮齿动物饲养中最现代化的设备，包括通风高效颗粒空气（HEPA）过滤啮齿动物饲养系统及其配件。到2006年底，该设施将配备4，920个笼子（相当于12，220只啮齿动物），并可容纳6，460个笼子（16，070只啮齿动物），并购买额外的笼子系统（架）。本申请的目的是确保随着TSRI继续扩大其研究活动，其ACF同时升级，以满足当前研究者和待招募研究者对动物饲养的需求增加。这将通过在未来三年购买19个单独通风的笼子系统来实现，以处理额外的1，830个笼子，以容纳3，850只额外的啮齿动物，并提供用于维护和清洁的摆动架。这也将确保ACF继续提供最高标准的动物护理，完全符合美国农业部动物福利法和PHS关于动物设施的政策。 具体目标：这项建议的目的，是透过购买19套经高效微粒空气过滤器过滤及通风的鼠只饲养单位系统及配件，以增加我们的动物活动中心设施的容量，容许饲养12，220只鼠只。

DESCRIPTION (provided by applicant): Over the past seven years, The Saban Research Institute (TSRI) of Childrens Hospital Los Angeles (CHLA) has experienced a substantial growth at multiple levels. Research faculty recruitment has increased by 146percent, extramural funding for research has almost doubled, NIH funding has more than doubled, endowments have increased by 250%, and space has increased by 160% with the completion in June 2003of a new research facility, the Saban Research building that is home of a new state-of-the-art animal care facility (ACF). As a result, the population of rodents in the ACF has doubled over the last 3 years. The facility is equipped with the most modern equipment in small rodent husbandry including ventilated high-efficiency-particulate-air (HEPA) filtered rodent housing systems and their accessories. By the end of the year 2006, the facility will be equipped with 4,920 cages (equivalent to 12,220 rodents), and could accommodate a total of 6,460 cages (16,070 rodents) with the purchase of additional caging systems (racks). The goal of this application is to insure that as TSRI continues to expand its research activities, its ACF is simultaneously upgraded to meet the increased demand for animal housing from current investigators and investigators to be recruited. This will be achieved through the purchase of 19 individually ventilated caging systems over the next 3 years to handle additional 1,830 cages to have 3,850 additional rodents and provide swing racks for maintenance and cleaning. This will also insure that the ACF continues to provide the highest standard in animal care in full compliance with the USDA Animal Welfare Act and PHS policies in regard to animal facilities. Specific aim: The aim of this proposal is to increase the capacity of our ACF to allow the housing of 12,220 rodents by the purchase of 19 HEPA-filtered, ventilated rodent housing unit systems and accessories.