Effects of Focal Brain Injury on Local-Global Audition

局灶性脑损伤对局部-整体试镜的影响

• 批准号: 7474839
• 负责人: ALEXANDRA LIST
• 金额: $ 1.22万
• 依托单位: UNIVERSITY OF WALES, BANGOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-12 至 2010-02-11
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7474839
• 关键词: Adopted; Affect; Area; Attention; Auditory; Bilateral; Brain Injuries; Cognition; Complement; Data Collection; Focal Brain Injuries; Goals; Impairment; Individual; Investigation; Left; Lesion; Modality; Music; Neurologic; Parietal; Patients; Perception; Plant Leaves; Process; Research; Research Proposals; Sensory; Side; Signal Transduction; Stimulus; Structure; Superior temporal gyrus; System; Testing; Training; Trees; Vision; Visual; association cortex; brain behavior; follow-up; forest; neuroimaging; novel; novel strategies; perceptual organization; relating to nervous system; research study; split brain

DESCRIPTION (provided by applicant): The current research proposal aims to implement new stimuli in an investigation of the underlying neural substrates involved in auditory local and global perceptual organization. To accomplish this goal, we plan to test patients with unilateral lesions to the posterior superior temporal gyrus and the surrounding temporal-parietal association cortex, with special attention to whether lateralization of function occurs as in visual hierarchical processing (namely, biases for right and left hemisphere involvement in global and local processing, respectively). These investigations will be complemented with two follow up experiments: one investigating whether bilateral parietal damage affects attention to global organization (as occurs with similar lesions in visual hierarchical processing) and whether, in neurologically-intact individuals, rTMS over right or left pSTG/TPJ can produce selective deficits in global or local auditory processing, respectively. Together, the proposed studies will provide the applicant with a wealth of novel training opportunities. The current research will also result in a valuable collection of data from convergent approaches to examining brain-behavior relationships necessary for auditory perceptual organization.

描述（由申请人提供）：目前的研究计划旨在在涉及听觉局部和全局感知组织的潜在神经基质的研究中实施新的刺激。为了实现这一目标，我们计划测试患有单侧颞上回和周围颞顶叶联合皮层病变的患者，特别关注功能侧化是否发生在视觉分层处理中（即，分别参与全局和局部处理的右半球和左半球偏倚）。这些研究将通过两个后续实验进行补充：一个是研究双侧顶叶损伤是否会影响对全局组织的注意（就像在视觉分层处理中发生的类似病变一样），以及在神经系统完好的个体中，rTMS对右侧或左侧pSTG/TPJ的影响是否会分别在全局或局部听觉处理中产生选择性缺陷。这些建议的研究将为申请人提供丰富的新培训机会。目前的研究还将从检验听觉感知组织所必需的大脑-行为关系的收敛方法中收集有价值的数据。