Attentional Recovery: Behavioral, ERP and fMRI Measures

注意力恢复：行为、ERP 和功能磁共振成像测量

• 批准号: 6886495
• 负责人: ALEXANDRA LIST
• 金额: $ 2.84万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6886495
• 关键词: attention; clinical research; electroencephalography; evoked potentials; functional magnetic resonance imaging; hemodynamics; human subject; neural plasticity; neurophysiology; neuropsychological tests; neuropsychology; predoctoral investigator; rehabilitation; space perception; stroke; visual tracking

DESCRIPTION (provided by applicant): The current research will characterize the electrophysiological and hemodynamic changes coincident with behavioral recovery in patients with hemispatial neglect. Hemispatial neglect is a prevalent impairment caused by stroke and is prognostic for poor recovery. Patients with neglect are impaired in attending to the side of space opposite their lesion. Thus, to track recovery, the proposed project will examine changes in stroke patients' performance on an attentional task. To compliment the behavioral data, both event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI) methods will be used to provide a neurobiological profile of recovery. The electrophysiological data will be instrumental in characterizing any temporal changes in attentional orienting. The fMRI data will provide information as to which brain areas, if any, functionally compensate for the damaged tissue. Although the data will contribute to psychological models of attentional allocation, they will also importantly broaden the understanding of recovery from neglect (in particular) and neural plasticity (in general). Hopefully these data, along with other researchers' investigations, will inspire new rehabilitative approaches for stroke patients with hemispatial neglect.

描述（由申请人提供）： 目前的研究将描述半侧空间忽视患者与行为恢复一致的电生理和血流动力学变化。半侧空间忽视是中风引起的一种普遍损伤，预示着恢复不佳。被忽视的患者在关注病变相对侧的空间方面受到损害。因此，为了跟踪康复情况，拟议的项目将检查中风患者在注意力任务中表现的变化。为了补充行为数据，事件相关电位（ERP）和功能磁共振成像（fMRI）方法将用于提供恢复的神经生物学概况。电生理学数据将有助于表征注意力定向的任何时间变化。功能磁共振成像数据将提供有关哪些大脑区域（如果有）对受损组织进行功能补偿的信息。尽管这些数据将有助于注意力分配的心理模型，但它们也将重要地拓宽对从忽视中恢复（特别是）和神经可塑性（一般而言）的理解。希望这些数据以及其他研究人员的调查能够为患有半侧空间忽视的中风患者提供新的康复方法。