Effects of Focal Brain Injury on Local-Global Audition

描述（由申请人提供）：目前的研究计划旨在在涉及听觉局部和全局感知组织的潜在神经基质的研究中实施新的刺激。为了实现这一目标，我们计划测试患有单侧颞上回和周围颞顶叶联合皮层病变的患者，特别关注功能侧化是否发生在视觉分层处理中（即，分别参与全局和局部处理的右半球和左半球偏倚）。这些研究将辅以后续实验，研究在神经系统完好的个体中，rTMS对右侧或左侧pSTG/TPJ是否会分别产生整体或局部听觉加工的选择性缺陷。结合神经心理学和经颅磁刺激提供了机会来区分中风后由于神经重组或仅仅是局灶性破坏造成的缺陷。总之，拟议的研究将为候选人提供丰富的新培训机会。目前的研究还将从检验听觉感知组织所必需的大脑-行为关系的收敛方法中收集有价值的数据。

DESCRIPTION (provided by applicant): The current research proposal aims to implement new stimuli in an investigation of the underlying neural substrates involved in auditory local and global perceptual organization. To accomplish this goal, we plan to test patients with unilateral lesions to the posterior superior temporal gyrus and the surrounding temporal-parietal association cortex, with special attention to whether lateralization of function occurs as in visual hierarchical processing (namely, biases for right and left hemisphere involvement in global and local processing, respectively). These investigations will be complemented with a follow up experiment investigating whether, in neurologically-intact individuals, rTMS over right or left pSTG/TPJ can produce selective deficits in global or local auditory processing, respectively. Combining neuropsychology and TMS provides the opportunity to distinguish between deficits due to neural reorganization after stroke or simply to focal disruption. Together, the proposed studies will provide the candidate with a wealth of novel training opportunities. The current research will also result in a valuable collection of data from convergent approaches to examining brain-behavior relationships necessary for auditory perceptual organization.