Effects of Focal Brain Injury on Local-Global Audition

描述（由申请人提供）：目前的研究计划旨在实施新的刺激，在调查的潜在神经基板参与听觉本地和全球的知觉组织。为了实现这一目标，我们计划测试患者单侧病变的后上级颞回和周围的颞顶叶联合皮层，特别注意是否出现功能偏侧化的视觉分层处理（即，偏见的左右半球参与全球和本地处理，分别）。这些调查将补充一个后续的实验调查是否，在神经系统完整的个人，rTMS在右或左pSTG/TPJ可以产生选择性赤字，分别在全球或局部听觉处理。结合神经心理学和经颅磁刺激提供了机会，以区分由于中风后的神经重组或简单的局灶性破坏的缺陷。总之，拟议的研究将为候选人提供丰富的新颖的培训机会。目前的研究也将导致从收敛的方法来检查听觉知觉组织所需的大脑行为关系的数据收集有价值。

DESCRIPTION (provided by applicant): The current research proposal aims to implement new stimuli in an investigation of the underlying neural substrates involved in auditory local and global perceptual organization. To accomplish this goal, we plan to test patients with unilateral lesions to the posterior superior temporal gyrus and the surrounding temporal-parietal association cortex, with special attention to whether lateralization of function occurs as in visual hierarchical processing (namely, biases for right and left hemisphere involvement in global and local processing, respectively). These investigations will be complemented with a follow up experiment investigating whether, in neurologically-intact individuals, rTMS over right or left pSTG/TPJ can produce selective deficits in global or local auditory processing, respectively. Combining neuropsychology and TMS provides the opportunity to distinguish between deficits due to neural reorganization after stroke or simply to focal disruption. Together, the proposed studies will provide the candidate with a wealth of novel training opportunities. The current research will also result in a valuable collection of data from convergent approaches to examining brain-behavior relationships necessary for auditory perceptual organization.