Effects of Focal Brain Injury on Local-Global Audition

描述(由申请人提供)：目前的研究方案旨在实施新的刺激，以调查涉及听觉局部和全局知觉组织的潜在神经底物。为了实现这一目标，我们计划测试单侧病变的患者的后颞叶上回和周围的颞顶联合皮质，特别注意功能的偏侧化是否发生在视觉分层加工中(即分别偏向于左右半球参与全局和局部加工)。这些研究将与后续实验相辅相成，研究在神经学完好的个体中，右侧或左侧pSTG/TPJ上的rTMS是否会分别在全局或局部听觉加工中产生选择性缺陷。神经心理学和TMS的结合提供了区分中风后神经重组或单纯局灶性破坏所致的缺陷的机会。总之，拟议的研究将为应聘者提供丰富的新培训机会。目前的研究还将从检验听觉知觉组织所需的大脑-行为关系的聚合方法中收集有价值的数据。

DESCRIPTION (provided by applicant): The current research proposal aims to implement new stimuli in an investigation of the underlying neural substrates involved in auditory local and global perceptual organization. To accomplish this goal, we plan to test patients with unilateral lesions to the posterior superior temporal gyrus and the surrounding temporal-parietal association cortex, with special attention to whether lateralization of function occurs as in visual hierarchical processing (namely, biases for right and left hemisphere involvement in global and local processing, respectively). These investigations will be complemented with a follow up experiment investigating whether, in neurologically-intact individuals, rTMS over right or left pSTG/TPJ can produce selective deficits in global or local auditory processing, respectively. Combining neuropsychology and TMS provides the opportunity to distinguish between deficits due to neural reorganization after stroke or simply to focal disruption. Together, the proposed studies will provide the candidate with a wealth of novel training opportunities. The current research will also result in a valuable collection of data from convergent approaches to examining brain-behavior relationships necessary for auditory perceptual organization.