Melanoma genetics: clinical translation of the germline-somatic continuum

黑色素瘤遗传学：种系-体细胞连续体的临床转化

• 批准号: nhmrc : 1195581
• 金额: $ 223.14万
• 依托单位国家: 澳大利亚
• 项目类别: Investigator Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/melanoma-genetics-clinical-somatic-continuum/1779006
• 关键词: Melanoma; genetics; clinical; translation; germline

While new targeted and immune therapies can improve prognosis from metastatic melanoma, long-term survival for most patients remains elusive due to drug resistance or failure of the immune system to kill the tumour. There thus remains a significant need to improve early detection, monitoring of relapse, and treatment strategies, to increase survival and provide cures. My research vision addresses these three pillars of cancer research using innovative and cutting edge genetic approaches.

虽然新的靶向和免疫疗法可以改善转移性黑色素瘤的预后，但由于耐药性或免疫系统未能杀死肿瘤，大多数患者的长期生存仍然难以实现。因此，仍然需要改进早期发现、复发监测和治疗策略，以提高存活率和提供治疗方法。我的研究愿景是使用创新和尖端的遗传方法解决癌症研究的这三个支柱。