Neurobiological Aspects of Aging

描述(由申请者提供)：本指导临床科学家发展计划的目的是支持在与衰老相关的神经科学学科中优秀的医生实习生的职业发展，导致研究独立。培训将作为一项联合计划进行，利用当地神经科学界的各种和广泛的资源，包括加州大学圣地亚哥分校、斯克里普斯研究基金会、索尔克研究所和伯纳姆基金会。该项目的优秀申请者将从加州大学圣迭戈分校神经科学系临床神经学项目的本地毕业生和全国神经学培训项目中招聘。每年申请1个职位，为期5年，共计5个培训职位。该项目将由神经科学系管理，这是一个基础科学和临床的联合部门。该学院在神经系统老化研究的遗传、分子、细胞、系统、行为和模型方面拥有相当大的实力。这些教师还积极参与翻译研究，从而直接影响人类疾病的治疗。该培训计划将为被任命的人员提供三种类型的学术经验来领导 研究独立性：1)基础神经科学培训，通过正式的神经科学研究生院课程工作和实验室研究轮换完成，2)3-4年的强化指导研究，以及3)连续的研讨会、老龄课程和讲座。没有博士学位的学员将有机会参加加州大学圣迭戈分校神经科学研究生项目并获得神经科学博士学位。该培训项目旨在让学员接触到广泛的神经科学主题，这些主题需要从全面和学术的角度来解决与衰老相关的问题，从基因表达的研究到整个系统/行为方法的研究。然后，个别受训者将选择一个学科作为重点，并培养一个职业研究主题。

DESCRIPTION (provided by applicant): The purpose of this Mentored Clinical Scientist Development Program is to support the career development of outstanding physician trainees in an aging-related neuroscience discipline, leading-to-research independence. Training will be conducted as a joint program taking advantage of the diverse and extensive resources of the local neuroscience community, including the University of California-San Diego, Scripps Research Foundation, the Salk Institute, and the Burnham Foundation. Outstanding applicants for the program will be recruited both locally from graduating residents of the clinical neurology program in the Department of Neurosciences at UCSD, and from neurology training programs nationally. 1 slot per year is requested for a 5 year period, totaling 5 training positions. The program will be administered by the Department of Neurosciences, a joint basic science-clinical department. The faculty possesses considerable strength in the genetic, molecular, cellular, systems, behavioral and modeling aspects of nervous system aging research. The faculty are also active in translational research, thereby directly impacting the treatment of human disease. The training program will provide appointees three types of academic experiences to lead to research independence: 1) Basic neuroscience training, accomplished by formal Neuroscience Graduate Program course work and laboratory research rotations, 2) a 3-4 year period of intensive mentored research, and 3) a continuous curriculum of symposia, coursework in aging, and lectures. Trainees who do not have a Ph.D. degree will have the opportunity to enroll in the UCSD Neuroscience Graduate Program and earn a Neuroscience doctoral degree The training program intends to expose the trainees to a breadth of neuroscience topics that are required to approach aging-related questions from a comprehensive and scholarly vantage point, ranging from the study of gene expression to whole systems/behavioral approaches. Individual trainees will then choose a discipline within which to focus and foster a career research topic.