Defining Astrocyte Engram Ensembles During Memory Formation
定义记忆形成过程中的星形胶质细胞印迹整体
基本信息
- 批准号:10722056
- 负责人:
- 金额:$ 44万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-01 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAblationAcuteAlzheimer&aposs DiseaseAmnesiaAnxietyAstrocytesBehaviorBehavioralBrainCalciumCell SeparationCellsClozapineCognitionDataDementiaDiphtheria ToxinDiseaseEventExhibitsExperimental DesignsExposure toFOS geneFreezingGene ExpressionGoalsHippocampusImageImmediate-Early GenesImpairmentLabelLearningLigandsMapsMeasuresMemoryMemory impairmentMolecularMolecular AnalysisMorphologyMusNatureNeuronsOutputOxidesPhysiologicalPlayPopulationPost-Traumatic Stress DisordersProcessPropertyResolutionRetrievalRoleSignal TransductionSliceSpecificitySynapsesSynaptic plasticitySystemTestingTraumaViralViruscalcium indicatorconditioned feardentate gyrusexperimental studyinducible gene expressioninsightmemory encodingmemory processmemory recallmemory retrievalnervous system disorderneuronal circuitryprospectivereconstructiontooltranscriptome sequencingtwo-photon
项目摘要
Summary
Astrocytes play diverse and indispensable roles in brain function. Participating as a component of the ‘tripartite
synapse’, a single astrocyte is estimated to contact up to 100,000 neuronal synapses in the hippocampus. Notably,
studies have identified essential functions of astrocytes in hippocampal circuits, where astrocytes are required for
regulating synaptic plasticity including LTP, a key process associated with learning and memory. Recent studies
have shown that enhancing Gq-signaling in astrocytes promotes LTP and enhances acute memory, while impairing
astrocyte function suppresses LTP and memory, highlighting central roles for astrocytes in memory-dependent
tasks. Learning events invoke activity and plasticity among a discrete ensemble of cells. Activation of these
ensembles by learning and reactivated during memory recall constitute the physical substrate of memory and are
referred to as engrams. Despite the critical involvement of astrocytes in learning and memory processes, the study
of memory engrams has been limited exclusively to neuronal ensembles. The goal of this proposal is to study the
potential of astrocyte engrams as a substrate of memory and to understand the nature and function of hippocampal
astrocyte ensembles.
We have created a host of mouse lines and associated AAV-viral tools the enable us to label and
manipulate astrocytes during learning events in the hippocampus. Preliminary studies with these tools indicate that
we can label ensembles of astrocytes after learning and that reactivation of these same astrocytes promotes
memory recall. Based on the strength of these preliminary data and the associated tools we have built, we propose
the following specific aims. In specific aim1, we will label astrocyte ensembles after learning and characterize
whether they exhibit engram properties. In specific aim2, we will manipulate the prospective engram astrocyte
populations and determine whether they encode memory storage and recall. In specific aim3, we will characterize
the cellular and molecular properties of these labeled astrocyte engram populations.
总结
项目成果
期刊论文数量(0)
专著数量(0)
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Benjamin Deneen其他文献
Benjamin Deneen的其他文献
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{{ truncateString('Benjamin Deneen', 18)}}的其他基金
Astrocyte Transcriptional Dependencies in Brain Circuits
脑回路中星形胶质细胞的转录依赖性
- 批准号:
10665221 - 财政年份:2023
- 资助金额:
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Systematic Characterization and Targeting of Neomorphic Drivers in Cancer
癌症新形态驱动因素的系统表征和靶向
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10717973 - 财政年份:2023
- 资助金额:
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Transcriptional Regulation in ZFTA-RELA Ependymoma
ZFTA-RELA 室管膜瘤的转录调控
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10383061 - 财政年份:2022
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MOLECULAR AND CELLULAR CONTROL OF INJURY-INDUCED ASTROGENESIS
损伤引起的星形细胞生成的分子和细胞控制
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$ 44万 - 项目类别:
Defining Roles for Astrocyte Subpopulations in the Aging Brain
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- 批准号:
10192033 - 财政年份:2021
- 资助金额:
$ 44万 - 项目类别:
Defining Roles for Astrocyte Subpopulations in the Aging Brain
定义星形胶质细胞亚群在衰老大脑中的作用
- 批准号:
10581539 - 财政年份:2021
- 资助金额:
$ 44万 - 项目类别:
Defining Roles for Astrocyte Subpopulations in the Aging Brain
定义星形胶质细胞亚群在衰老大脑中的作用
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10390425 - 财政年份:2021
- 资助金额:
$ 44万 - 项目类别:
Defining Roles for Astrocyte Subpopulations in the Aging Brain
定义星形胶质细胞亚群在衰老大脑中的作用
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10708356 - 财政年份:2021
- 资助金额:
$ 44万 - 项目类别:
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