Defining Astrocyte Engram Ensembles During Memory Formation

定义记忆形成过程中的星形胶质细胞印迹整体

基本信息

  • 批准号:
    10722056
  • 负责人:
  • 金额:
    $ 44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-01 至 2025-07-31
  • 项目状态:
    未结题

项目摘要

Summary Astrocytes play diverse and indispensable roles in brain function. Participating as a component of the ‘tripartite synapse’, a single astrocyte is estimated to contact up to 100,000 neuronal synapses in the hippocampus. Notably, studies have identified essential functions of astrocytes in hippocampal circuits, where astrocytes are required for regulating synaptic plasticity including LTP, a key process associated with learning and memory. Recent studies have shown that enhancing Gq-signaling in astrocytes promotes LTP and enhances acute memory, while impairing astrocyte function suppresses LTP and memory, highlighting central roles for astrocytes in memory-dependent tasks. Learning events invoke activity and plasticity among a discrete ensemble of cells. Activation of these ensembles by learning and reactivated during memory recall constitute the physical substrate of memory and are referred to as engrams. Despite the critical involvement of astrocytes in learning and memory processes, the study of memory engrams has been limited exclusively to neuronal ensembles. The goal of this proposal is to study the potential of astrocyte engrams as a substrate of memory and to understand the nature and function of hippocampal astrocyte ensembles. We have created a host of mouse lines and associated AAV-viral tools the enable us to label and manipulate astrocytes during learning events in the hippocampus. Preliminary studies with these tools indicate that we can label ensembles of astrocytes after learning and that reactivation of these same astrocytes promotes memory recall. Based on the strength of these preliminary data and the associated tools we have built, we propose the following specific aims. In specific aim1, we will label astrocyte ensembles after learning and characterize whether they exhibit engram properties. In specific aim2, we will manipulate the prospective engram astrocyte populations and determine whether they encode memory storage and recall. In specific aim3, we will characterize the cellular and molecular properties of these labeled astrocyte engram populations.
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项目成果

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Benjamin Deneen其他文献

Benjamin Deneen的其他文献

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{{ truncateString('Benjamin Deneen', 18)}}的其他基金

Astrocyte Transcriptional Dependencies in Brain Circuits
脑回路中星形胶质细胞的转录依赖性
  • 批准号:
    10665221
  • 财政年份:
    2023
  • 资助金额:
    $ 44万
  • 项目类别:
Systematic Characterization and Targeting of Neomorphic Drivers in Cancer
癌症新形态驱动因素的系统表征和靶向
  • 批准号:
    10717973
  • 财政年份:
    2023
  • 资助金额:
    $ 44万
  • 项目类别:
Transcriptional Regulation in ZFTA-RELA Ependymoma
ZFTA-RELA 室管膜瘤的转录调控
  • 批准号:
    10736436
  • 财政年份:
    2023
  • 资助金额:
    $ 44万
  • 项目类别:
Cellular and Molecular Mechanisms of GBM Infiltration
GBM 浸润的细胞和分子机制
  • 批准号:
    10583559
  • 财政年份:
    2022
  • 资助金额:
    $ 44万
  • 项目类别:
Cellular and Molecular Mechanisms of GBM Infiltration
GBM 浸润的细胞和分子机制
  • 批准号:
    10383061
  • 财政年份:
    2022
  • 资助金额:
    $ 44万
  • 项目类别:
MOLECULAR AND CELLULAR CONTROL OF INJURY-INDUCED ASTROGENESIS
损伤引起的星形细胞生成的分子和细胞控制
  • 批准号:
    10335708
  • 财政年份:
    2021
  • 资助金额:
    $ 44万
  • 项目类别:
Defining Roles for Astrocyte Subpopulations in the Aging Brain
定义星形胶质细胞亚群在衰老大脑中的作用
  • 批准号:
    10192033
  • 财政年份:
    2021
  • 资助金额:
    $ 44万
  • 项目类别:
Defining Roles for Astrocyte Subpopulations in the Aging Brain
定义星形胶质细胞亚群在衰老大脑中的作用
  • 批准号:
    10581539
  • 财政年份:
    2021
  • 资助金额:
    $ 44万
  • 项目类别:
Defining Roles for Astrocyte Subpopulations in the Aging Brain
定义星形胶质细胞亚群在衰老大脑中的作用
  • 批准号:
    10390425
  • 财政年份:
    2021
  • 资助金额:
    $ 44万
  • 项目类别:
Defining Roles for Astrocyte Subpopulations in the Aging Brain
定义星形胶质细胞亚群在衰老大脑中的作用
  • 批准号:
    10708356
  • 财政年份:
    2021
  • 资助金额:
    $ 44万
  • 项目类别:

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