Project 2: Systems biology analyses of RHCMV/SIV and IL-15 mechanisms of immune programming

项目2:RHCMV/SIV和IL-15免疫编程机制的系统生物学分析

基本信息

  • 批准号:
    10723640
  • 负责人:
  • 金额:
    $ 32.77万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-01 至 2028-07-31
  • 项目状态:
    未结题

项目摘要

Project 2 brings a systems biology approach, “systems vaccinology”, to investigate immune response programing by IL-15 and RhCMV/SIV vaccine. Our goal is to define the molecular response by which IL-15 and RhCMV/SIV vaccine program the protection-predictive immune phenotype in whole blood to vaccination, what we term as the “whole blood protection-predictive transcriptomic signature” [wbPPTS] that predicts and underlies vaccine protection from SIV infection. We will conduct three Aims including i) Determine the response to IL-15 in monocytes and T cells; ii) Define the tissue and cell-specific transcriptome correlates of IL-15 signaling linked with RhCMV/SIV vaccination phenotype to program the wbPPTS, and iii) Validate RhCMV/SIV vaccination tissue and wbPPTS signature linkage with protection against SIV challenge. Our research design features in vitro and ex vivo models for analyses of cell signaling/responses to IL-15, and in vivo analyses of cell and tissue application of three "omics" platforms including single cell RNA sequencing (scRNAseq and CITEseq), bulk RNAseq, and tissue spatial profiling. Our bioinformatics/computational analyses will integrate functional genomics data sets with immune response and protection phenotypes to determine the molecular and cellular features directing the wbPPTS and vaccine protection. We will conduct bioinformatics of RhCMV/SIV transcriptomic responses in an independent vaccination/SIV challenge cohort to ascertain specific tissue signature of protection and the wbPPTS. This work will be conducted in a collaborative framework conjunction with Cores A-C and Project 1.
项目2采用系统生物学方法,即“系统疫苗学”来研究免疫反应

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Michael Gale其他文献

Michael Gale的其他文献

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{{ truncateString('Michael Gale', 18)}}的其他基金

Core C: Systems Biology Core
核心 C:系统生物学核心
  • 批准号:
    10723638
  • 财政年份:
    2023
  • 资助金额:
    $ 32.77万
  • 项目类别:
MECHANISMS PROGRAMMING PROTECTIVE IMMUNITY FROM RhCMV-SIV VACCINE AND IL-15 ACTIONS
RhCMV-SIV 疫苗和 IL-15 作用的保护性免疫编程机制
  • 批准号:
    10723635
  • 财政年份:
    2023
  • 资助金额:
    $ 32.77万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10723636
  • 财政年份:
    2023
  • 资助金额:
    $ 32.77万
  • 项目类别:
Omics, Bioinformatics, and Data Management Core
组学、生物信息学和数据管理核心
  • 批准号:
    10709011
  • 财政年份:
    2022
  • 资助金额:
    $ 32.77万
  • 项目类别:
Omics, Bioinformatics, and Data Management Core
组学、生物信息学和数据管理核心
  • 批准号:
    10619301
  • 财政年份:
    2022
  • 资助金额:
    $ 32.77万
  • 项目类别:
University of Washington Arboviral Research Network (UWARN)
华盛顿大学虫媒病毒研究网络 (UWARN)
  • 批准号:
    10687434
  • 财政年份:
    2022
  • 资助金额:
    $ 32.77万
  • 项目类别:
University of Washington Arboviral Research Network (UWARN)
华盛顿大学虫媒病毒研究网络 (UWARN)
  • 批准号:
    10493552
  • 财政年份:
    2021
  • 资助金额:
    $ 32.77万
  • 项目类别:
Host inflammatory response to SARS-CoV-2
宿主对 SARS-CoV-2 的炎症反应
  • 批准号:
    10192439
  • 财政年份:
    2021
  • 资助金额:
    $ 32.77万
  • 项目类别:
University of Washington Arboviral Research Network (UWARN)
华盛顿大学虫媒病毒研究网络 (UWARN)
  • 批准号:
    10770598
  • 财政年份:
    2020
  • 资助金额:
    $ 32.77万
  • 项目类别:
University of Washington Arboviral Research Network (UWARN)
华盛顿大学虫媒病毒研究网络 (UWARN)
  • 批准号:
    10170249
  • 财政年份:
    2020
  • 资助金额:
    $ 32.77万
  • 项目类别:

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