University of Washington Arboviral Research Network (UWARN)
华盛顿大学虫媒病毒研究网络 (UWARN)
基本信息
- 批准号:10687434
- 负责人:
- 金额:$ 116.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-16 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAdministrative CoordinationAlphavirusAnimalsAntibodiesArbovirus InfectionsArbovirusesAreaArthropod VectorsBackBacteriologyBindingBiological AssayBiological MarkersBloodBody FluidsBrazilCell SeparationChikungunya virusClinicalClinical ManagementClinical TrialsCollaborationsCollectionCongoContainmentDataDengueDengue InfectionDengue VirusDetectionDevelopmentDiagnosisDiagnosticDiagnostic ReagentDiseaseEmergency SituationEmerging Communicable DiseasesEngineeringEnzyme-Linked Immunosorbent AssayEpitopesFar EastFeverFlavivirusFluorescenceFreezingFutureGenomic approachHumanImmune responseImmune systemImmunoglobulin GIndividualInfectionInfectious Diseases ResearchInnate Immune ResponseInnate Immune SystemInstitutesInstitutionInternationalInterventionInvestigationJapanese EncephalitisKnowledgeLaboratoriesLaboratory ResearchLeadLightLogisticsMeasurementMetagenomicsMicrocephalyMolecularMonitorMonoclonal AntibodiesNatural ImmunityOropouche virusOrthobunyavirusOutcomePakistanParasitic infectionPathogenesisPathway interactionsPatientsPopulationPrevalenceProcessProductionProtein EngineeringProteinsReadinessReagentResearchResourcesRift Valley FeverRiskSamplingSenegalSensitivity and SpecificitySerologySeroprevalencesSiteSouth AfricaSouth AmericaSpecimenStatistical Data InterpretationSystemTaiwanTechnologyTechnology TransferTestingThe science of MycologyTherapeuticTimeUniversitiesVaccinesVariantVeterinariansViralViral AntibodiesViral Hemorrhagic FeversViral Load resultVirusVirus DiseasesWashingtonYellow FeverZIKAZika Virusantagonistarthropod-bornebasebiobankcandidate markerchikungunyacohortcross reactivitydata managementdesignexperienceglobal healthglobal health emergencyhuman monoclonal antibodiesimprovedimproved outcomeinnovationneutralizing antibodyneutralizing monoclonal antibodiesnext generation sequencingnovelnovel diagnosticsnovel strategiespandemic diseasepandemic preparednesspathogenpathogenic viruspoint of carepopulation basedprospectivesevere denguetherapeutic targettranscriptomicsviral detectionvirologyvirus host interaction
项目摘要
Abstract: University of Washington Arboviral Research Network (UWARN)
The University of Washington Arboviral Research Network (UWARN) will address emerging and re-emerging
infectious diseases by carrying out research on arboviruses that include current high burden pathogens including
dengue, chikungunya, and Zika viruses. Arboviruses also include emerging and re-emerging viruses such as
Mayaro, Una, Usutu, Japanese encephalitis, yellow fever, Crimean-Congo hemorrhagic fever, and Oropouche
viruses. UWARN will leverage the UW Metacenter for Pandemic Disease Preparedness and strong research
laboratory partners in Brazil, Senegal, South Africa, Pakistan and Taiwan as well as the UW Department of
Global Health global reach in capacity building. The UWARN international Collaborating Partners have
institution-based and population-based cohorts in place to carry out the planned research and monitor for new
virus emergence. The proposed UWARN research will create new human viral-neutralizing monoclonal
antibodies (Hu-nMabs) that can be used as therapeutics or diagnostics. UWARN research will also create new
diagnostics, created ab initio by the Institute for Protein Design, as artificial proteins that release light when
antibodies to virus are present in body fluids. Finally, UWARN research will generate an understanding of how
viruses manipulate the human innate immune system, and this information will be used to design biomarkers to
predict severe disease as well as to suggest host-directed therapies that could lead to better outcomes after
arboviral infection. The proposed technologies are generic and could be rapidly adapted to any future emerging
arbovirus threat. UWARN collaborators span virology, bacteriology, mycology, and parasitic infections, such that
UWARN can respond to diverse emerging infectious diseases threats. UWARN international laboratories have
advanced capabilities including biorepositories with generator-power backed-up -80C freezers, next-generation
sequencing (NGS) capabilities, fluorescence cell sorting, and BSL-3 containment facilities. UWARN cohorts have
biobanked samples taken from individuals during acute febrile illnesses, with known and unknown arboviral
diseases, and partnership sites are poised for prospective collection of population and facility–based samples.
UWARN labs will use metagenomic NGS to detect novel viral emergence in affiliated cohorts. UWARN Partners
have collaborating entomologists and veterinarians to sample arthropod vectors and animal reservoirs as
needed. Additional innovative capacity included the Brazil UWARN partner’s mobile van with on board NGS
capability for real-time, on-site viral sequencing and sampling to viral identification in less than 18 hrs. A second
partner, IRESSEF in Senegal, plans to set up a similar mobile vehicle for viral sampling and sequencing in
Senegal and the Brazil group will collaborate with IRESSEF on technology transfer and best practices. UWARN
partners will serve as a resource to other Emerging Infectious Diseases Research Centers (EIDRC) providing
expertise in monoclonal antibodies, protein design, and host directed therapies.
摘要:华盛顿大学虫媒病毒研究网络(UWARN)
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael Gale其他文献
Michael Gale的其他文献
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{{ truncateString('Michael Gale', 18)}}的其他基金
Project 2: Systems biology analyses of RHCMV/SIV and IL-15 mechanisms of immune programming
项目2:RHCMV/SIV和IL-15免疫编程机制的系统生物学分析
- 批准号:
10723640 - 财政年份:2023
- 资助金额:
$ 116.6万 - 项目类别:
MECHANISMS PROGRAMMING PROTECTIVE IMMUNITY FROM RhCMV-SIV VACCINE AND IL-15 ACTIONS
RhCMV-SIV 疫苗和 IL-15 作用的保护性免疫编程机制
- 批准号:
10723635 - 财政年份:2023
- 资助金额:
$ 116.6万 - 项目类别:
Omics, Bioinformatics, and Data Management Core
组学、生物信息学和数据管理核心
- 批准号:
10709011 - 财政年份:2022
- 资助金额:
$ 116.6万 - 项目类别:
Omics, Bioinformatics, and Data Management Core
组学、生物信息学和数据管理核心
- 批准号:
10619301 - 财政年份:2022
- 资助金额:
$ 116.6万 - 项目类别:
University of Washington Arboviral Research Network (UWARN)
华盛顿大学虫媒病毒研究网络 (UWARN)
- 批准号:
10493552 - 财政年份:2021
- 资助金额:
$ 116.6万 - 项目类别:
Host inflammatory response to SARS-CoV-2
宿主对 SARS-CoV-2 的炎症反应
- 批准号:
10192439 - 财政年份:2021
- 资助金额:
$ 116.6万 - 项目类别:
University of Washington Arboviral Research Network (UWARN)
华盛顿大学虫媒病毒研究网络 (UWARN)
- 批准号:
10770598 - 财政年份:2020
- 资助金额:
$ 116.6万 - 项目类别:
University of Washington Arboviral Research Network (UWARN)
华盛顿大学虫媒病毒研究网络 (UWARN)
- 批准号:
10170249 - 财政年份:2020
- 资助金额:
$ 116.6万 - 项目类别:
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