NHP Core

NHP核心

• 批准号: 10724223
• 负责人: Dan H. Barouch
• 金额: $ 28.54万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-11 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724223
• 关键词: Animal Model; Animals; Blood specimen; Cataloging; Clinical; Complex; Data Analyses; Data Collection; Ensure; Goals; HIV-1; Human Resources; Infection; Infrastructure; Israel; Laboratories; Leadership; Logistics; Macaca mulatta; Medical center; Positioning Attribute; Procedures; Program Research Project Grants; Protocols documentation; Quality Control; Reagent; Research; SIV; Sampling; Technical Expertise; Tissue Sample; Vaccine Therapy; animal care; experience; in vivo; multiple omics; neutralizing antibody; nonhuman primate; programs; simian human immunodeficiency virus; vaccine trial

SUMMARY Infection of rhesus macaques with simian immunodeficiency virus (SIV) or simian-human immunodeficiency virus (SHIV) is a key animal model for HIV-1 infection. Nonhuman primates (NHP) are complex, higher order species that require specialized infrastructure and experienced staff in a research setting. Core D (NHP Core) aims to support this P01 program by providing all the expertise, infrastructure, reagents, personnel, animals, and logistics for the conduct of complex in vivo studies in rhesus macaques. Core D will involve leadership from Beth Israel Deaconess Medical Center and Bioqual and is well positioned to meet program objectives. The goal of Core D is to provide leadership and technical expertise to ensure consistency and quality control in animal selection, execution of study protocols, experimental procedures, sample acquisition and distribution, and data collection and analysis. To accomplish this goal, we propose three Specific Aims: Aim 1. To support this P01 program by selecting and providing rhesus macaques, providing exceptional animal care, and conducting experimental vaccine studies Aim 2. To provide facilities for the receipt, cataloging, processing, storage, and distribution of blood and tissue samples in compliance with Good Clinical Laboratory Practice Aim 3. To obtain and to maintain all required regulatory approvals for the proposed studies

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