I4C 2.0: Immunotherapy for Cure
I4C 2.0:免疫疗法治愈
基本信息
- 批准号:10615238
- 负责人:
- 金额:$ 467万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-16 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcademiaActive ImmunizationAgonistB-LymphocytesBindingClonal ExpansionCommunitiesCommunity NetworksDisease remissionEngineeringEnsureFeedbackFinancial SupportGoalsGovernmentHIV-1HumanImmuneImmune responseImmunologic SurveillanceImmunologicsImmunotherapyIndustryLogisticsMacaca mulattaMonkeysNatural Killer CellsPassive ImmunizationRegimenResearchResidual stateResourcesSIVSamplingT-LymphocyteTLR7 geneUnited States National Institutes of HealthVaccine TherapyViralViral reservoirViruschimeric antigen receptor T cellsclinical developmentcommunity engagementimmunoengineeringimprovedinnovationneutralizing antibodynovel strategiesoperationpreventprogramssimian human immunodeficiency virustherapeutic vaccinetimelinetranscriptomicsviral rebound
项目摘要
SUMMARY
The goals of I4C 2.0 are to advance our scientific understanding of the viral reservoir and to develop immunologic
strategies for HIV-1 remission and eradication by a highly collaborative and multifaceted research program
involving partnerships among academia, industry, government, and the community. Our overall hypothesis is
that multiple immunologic strategies will need to be explored and combined to achieve long-term, ART-
free virologic control or complete virus eradication, with the goal of selecting combination regimens to
advance into clinical development by the end of the proposed period of support. We propose three
Research Foci, a Management and Operations Section, and a Community Engagement Section.
Focus 1 (Mechanistic Basis of Reservoir Targeting and Viral Persistence)
Aim 1. To define a virologic, immunologic, and transcriptomic signature of viral persistence and rebound and to
determine how immunologic strategies target the viral reservoir in NHPs and humans
Aim 2. To define drivers of clonal expansion and persistence of the replication-competent viral reservoir in NHPs
and humans to enhance reservoir control and elimination
Focus 2 (Novel Strategies for Sustained Virus Remission)
Aim 1. To evaluate innovative immune engineering strategies that provide long-term T cell or Env-directed
immune control, including therapeutic vaccines, CAR-T cells, and engineered B cells
Aim 2. To combine approaches that augment humoral and cellular immune responses to achieve sustained
immunosurveillance and long-term ART-free virologic control
Focus 3 (Novel Strategies for Virus Eradication)
Aim 1. To evaluate innovative strategies for rapid elimination of the majority of the viral reservoir, including
improved LRAs combined with bNAbs, activated NK cells, and CAR-T cells
Aim 2. To combine the most effective approach to rapidly eliminate the majority of the viral reservoir with
sustained immunosurveillance to eliminate the residual viral reservoir
Management and Operations (MO) Section
Community Engagement (CE) Section
总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques.
- DOI:10.1038/s41541-022-00477-x
- 发表时间:2022-05-18
- 期刊:
- 影响因子:9.2
- 作者:Ventura, John D.;Nkolola, Joseph P.;Chandrashekar, Abishek;Borducchi, Erica N.;Liu, Jinyan;Mercado, Noe B.;Hope, David L.;Giffin, Victoria M.;McMahan, Katherine;Geleziunas, Romas;Murry, Jeffrey P.;Yang, Yunling;Lewis, Mark G.;Pau, Maria G.;Wegmann, Frank;Schuitemaker, Hanneke;Fray, Emily J.;Kumar, Mithra R.;Siliciano, Janet D.;Siliciano, Robert F.;Robb, Merlin L.;Michael, Nelson L.;Barouch, Dan H.
- 通讯作者:Barouch, Dan H.
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Dan H. Barouch其他文献
Pharmacokinetic interaction assessment of an HIV broadly neutralizing monoclonal antibody VRC07-523LS: a cross-protocol analysis of three phase 1 trials in people without HIV
- DOI:
10.1186/s12865-025-00687-7 - 发表时间:
2025-02-19 - 期刊:
- 影响因子:2.700
- 作者:
Tariro D. Chawana;Stephen R. Walsh;Lynda Stranix-Chibanda;Zvavahera M. Chirenje;Chenchen Yu;Lily Zhang;Kelly E. Seaton;Jack Heptinstall;Lu Zhang;Carmen A. Paez;Theresa Gamble;Shelly T. Karuna;Philip Andrew;Brett Hanscom;Magdalena E. Sobieszczyk;Srilatha Edupuganti;Cynthia L. Gay;Sharon B. Mannheimer;Christopher B. Hurt;Kathryn E. Stephenson;Laura L. Polakowski;Hans Spiegel;Margaret Yacovone;Stephanie Regenold;Catherine Yen;Jane AG. Baumblatt;Lucio Gama;Dan H. Barouch;Estelle Piwowar-Manning;Richard A. Koup;Georgia D. Tomaras;Ollivier Hyrien;Alison C. Roxby;Yunda Huang - 通讯作者:
Yunda Huang
On-patient medical record and mRNA therapeutics using intradermal microneedles
住院病历与使用皮内微针的信使核糖核酸疗法
- DOI:
10.1038/s41563-024-02115-4 - 发表时间:
2025-02-24 - 期刊:
- 影响因子:38.500
- 作者:
Jooli Han;Maria Kanelli;Yang Liu;John L. Daristotle;Apurva Pardeshi;Timothy A. Forster;Ari Karchin;Brandon Folk;Lukas Murmann;Lisa H. Tostanoski;Sebastian E. Carrasco;Shahad K. Alsaiari;Erika Yan Wang;Khanh Tran;Linzixuan Zhang;Behnaz Eshaghi;Lauren Levy;Sydney Pyon;Charles Sloane;Stacey Qiaohui Lin;Alicia Lau;Collin F. Perkinson;Moungi G. Bawendi;Dan H. Barouch;Frédo Durand;Robert Langer;Ana Jaklenec - 通讯作者:
Ana Jaklenec
Attenuated emMycobacterium tuberculosis/em vaccine protection in a low-dose murine challenge model
减毒鼠伤寒沙门菌疫苗在低剂量小鼠攻击模型中的保护作用
- DOI:
10.1016/j.isci.2023.106963 - 发表时间:
2023-06-16 - 期刊:
- 影响因子:4.100
- 作者:
Samuel J. Vidal;Daniel Sellers;Jingyou Yu;Shoko Wakabayashi;Jaimie Sixsmith;Malika Aid;Julia Barrett;Sage F. Stevens;Xiaowen Liu;Wenjun Li;Courtney R. Plumlee;Kevin B. Urdahl;Amanda J. Martinot;Dan H. Barouch - 通讯作者:
Dan H. Barouch
SIV proviruses seeded later in infection are harbored in short-lived CD4sup+/sup T cells
在感染后期植入的猴免疫缺陷病毒(SIV)前病毒存在于短寿命的CD4<sup>+</sup>T细胞中
- DOI:
10.1016/j.celrep.2025.115663 - 发表时间:
2025-05-27 - 期刊:
- 影响因子:6.900
- 作者:
Narmada Sambaturu;Emily J. Fray;Vivek Hariharan;Fengting Wu;Carolin Zitzmann;Francesco R. Simonetti;Dan H. Barouch;Janet D. Siliciano;Robert F. Siliciano;Ruy M. Ribeiro;Alan S. Perelson;Carmen Molina-París;Thomas Leitner - 通讯作者:
Thomas Leitner
Nonhuman primate antigenic cartography of SARS-CoV-2
非人类灵长类动物对 SARS-CoV-2 的抗原图谱
- DOI:
10.1016/j.celrep.2024.115140 - 发表时间:
2025-01-28 - 期刊:
- 影响因子:6.900
- 作者:
Annika Rössler;Antonia Netzl;Ninaad Lasrado;Jayeshbhai Chaudhari;Barbara Mühlemann;Samuel H. Wilks;Janine Kimpel;Derek J. Smith;Dan H. Barouch - 通讯作者:
Dan H. Barouch
Dan H. Barouch的其他文献
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{{ truncateString('Dan H. Barouch', 18)}}的其他基金
Multi-Omics Analysis of Broadly Neutralizing Antibodies and Therapeutic Vaccination
广泛中和抗体和治疗性疫苗的多组学分析
- 批准号:
10724219 - 财政年份:2023
- 资助金额:
$ 467万 - 项目类别:
Multi-Omics Correlates of Broadly Neutralizing Antibody Efficacy
广泛中和抗体功效的多组学关联
- 批准号:
10724224 - 财政年份:2023
- 资助金额:
$ 467万 - 项目类别:
CoVPN LOC Cross-Protocol Infrastructure Supplement for GY15 and GY16
适用于 GY15 和 GY16 的 CoVPN LOC 跨协议基础设施补充
- 批准号:
10571201 - 财政年份:2022
- 资助金额:
$ 467万 - 项目类别:
Project 2: Analysis of Reservoir Dynamics in SIV-Infected Rhesus Macaques
项目 2:感染 SIV 的恒河猴的储库动力学分析
- 批准号:
10599365 - 财政年份:2022
- 资助金额:
$ 467万 - 项目类别:
Project 2: Analysis of Reservoir Dynamics in SIV-Infected Rhesus Macaques
项目 2:感染 SIV 的恒河猴的储库动力学分析
- 批准号:
10459662 - 财政年份:2022
- 资助金额:
$ 467万 - 项目类别:
HIV Vaccines Clinical Trials Network Leadership and Operations Center
HIV 疫苗临床试验网络领导和运营中心
- 批准号:
10311601 - 财政年份:2021
- 资助金额:
$ 467万 - 项目类别:
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