Hispanic Alliance- Administrative Supplement-Strain-level pangenomic analyses ofvaginal Lactobacillus in a gradient of dysplasia in Hispanic women living in Puerto Rico.

改善医疗服务不足的人的医疗保健，包括我们的西班牙裔人口， 癌症、心脏代谢病和传染病等流行病仍然是一个重大挑战。 目前的申请是为了支持西班牙裔临床和转化研究联盟的发展 在波多黎各（联盟），旨在建立在现有的基础设施的波多黎各临床和 转化研究联盟（PR-CTRC和RCMI-CTR）和新兴传染病的独特专业知识 疾病和研究与灾害有关的条件及其对健康的影响。联盟的目标 是作为催化中心，以提高竞争力的研究人员进行研究， 获得额外资金用于针对高度流行疾病的临床和转化研究， 那些影响波多黎各医疗服务不足的人。联盟的长期目标是 通过以下方式改变大陆和波多黎各西班牙裔人群的临床和转化研究 促进跨学科合作和利用资源，以应对影响 西班牙裔社区 该联盟的成功实施将促进我们对西班牙裔健康的基本知识 在这个族群中，美国大陆人口中的代表性越来越大。该联盟是 创新，因为它将：（1）创建一个以西班牙裔为中心的研究中心，整合资源，以支持 研究人员在公关和国家合作伙伴;（2）实施西班牙裔真实的世界临床研究数据 仓库;（3）建立一个由不同社区组成的社区卫生和研究理事会 合作伙伴强调以社区为中心的双向研究重点，以影响卫生政策， 最终改善我们西班牙裔社区的健康状况。明确了联盟的总体目标 下面 具体目标1：加强全岛基础设施和人力资源网络，与当地 和国家合作伙伴在波多黎各进行临床和转化研究。 具体目标2：提供专业发展活动，以提高研究人员的发展能力 具有竞争力的临床和转化研究计划，重点是西班牙裔的健康需求。 具体目标3：促进法官和法官之间产生和传播知识， 社区，以改善影响波多黎各和整个美国的西班牙裔社区的健康结果 States. 具体目标4：促进和维持跨/多/跨学科合作的整合， 在机构、组织、社区网络和卫生系统内部和之间进行临床和转化研究 波多黎各和其他IDEA州的项目。

Improving health care for the medically underserved, including our Hispanic population, afflicted by prevalent diseases, such as cancer, cardio-metabolic and infectious diseases, remains a major challenge. The current application is to support the development of Hispanic Alliance for Clinical & Translational Research in Puerto Rico (Alliance), which aims to build on the existing infrastructure of the Puerto Rico Clinical and Translational Research Consortia (PR-CTRC an RCMI-CTR) and the unique expertise on emerging infectious diseases and the study of disaster-related conditions and their impact on Health. The objective of the Alliance is to serve as the catalytic center to enhance the competitiveness of investigators to conduct research and obtain additional funding for clinical and translational research addressing highly prevalent diseases and those that affect the medically underserved in Puerto Rico. The long-term goal of the Alliance is to transform clinical and translational research in Hispanic populations in the Mainland and in Puerto Rico by promoting inter-disciplinary collaboration and leverage of resources to address diseases affecting Hispanic communities. Successful implementation of the Alliance will advance our fundamental knowledge of Hispanic health in this ethnic subgroup, which is increasingly represented in the U.S. mainland population. The Alliance is innovative because it will: (1) create a Hispanic-centered research hub integrating resources to support researchers in PR and national partners; (2) implement the Hispanic Real World clinical research data warehouse; and (3) establish a Community Health & Research Council comprised of diverse community partners emphasizing a community-centered, bi-directional research focus to impact health policy and ultimately improving health outcomes in our Hispanic community. The Alliance overall aims are specified below. Specific Aim 1: Enhance an island-wide infrastructure and human resource network and synergize with local and national partners to conduct clinical and translational research in Puerto Rico. Specific Aim 2: Provide professional development activities to enhance the ability of investigators to develop competitive clinical and translational research programs with emphasis on Hispanic health needs. Specific Aim 3: Facilitate the generation and dissemination of knowledge to and from the bench and the community to improve health outcomes that affect Hispanic communities in Puerto Rico and across United States. Specific Aim 4: Catalyze and sustain the integration of trans/multi/inter disciplinary collaborations to conduct clinical and translational research within and across institutions, organizations, community networks and health programs in Puerto Rico and other IDeA states.