Epidemiology of diet, metabolism and non-alcoholic fatty liver disease in Hispanic/Latino adults

西班牙裔/拉丁裔成人饮食、代谢和非酒精性脂肪肝的流行病学

• 批准号: 10735454
• 负责人: Robert D Burk
• 金额: $ 77.27万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735454
• 关键词: Address; Adult; Affect; Bacteria; Biological; Biological Markers; Cirrhosis; Clinical; Cohort Studies; Collaborations; Consumption; Data; Diabetes Mellitus; Diet; Diet Modification; Disadvantaged; Disease; Disease Pathway; Ensure; Environment; Epidemiology; Essential Amino Acids; Fatty Liver; Fatty acid glycerol esters; Fibrosis; Fructose; Gastrointestinal tract structure; Genetic Determinism; Genetic Risk; Genetic Variation; High Prevalence; Hispanic; Hispanic Community Health Study/Study of Latinos; Human; Image; Indoles; Inflammation; Infrastructure; Intervention; Intervention Trial; Knowledge; Latin American; Latino; Latino Population; Letters; Life; Literature; Liver; Liver Fibrosis; Liver diseases; Magnetic Resonance Imaging; Malignant neoplasm of liver; Measurement; Measures; Mendelian randomization; Metabolic; Metabolic Diseases; Metabolism; Methodology; Methods; Minority Groups; Modification; Monitor; Obesity; Pharmacotherapy; Population; Poverty; Prevention; Prevotella; Production; Protons; Research; Research Design; Risk; Risk Factors; Risk Reduction; Sample Size; Sampling; Sampling Studies; Serum; Shapes; Stratification; Study of Latinos; Testing; Time; Translating; Tryptophan; Unhealthy Diet; Visit; aged; biobank; burden of illness; case control; cohort; contrast enhanced; cost; data integration; density; diabetes risk; disorder prevention; disorder risk; extracellular; genetic association; gut microbiome; high risk; improved; inter-individual variation; liver imaging; longitudinal analysis; metabolome; metabolomics; metagenomic sequencing; microbiome sequencing; migration; minority subjects; non-alcoholic fatty liver disease; nonalcoholic steatohepatitis; novel; pharmacologic; prevent; preventive intervention; primary outcome; progression risk; response; risk variant; screening; secondary outcome; sex; study population; sugar; therapy design

Abstract Nonalcoholic fatty liver disease (NAFLD) belongs to a cluster of metabolic conditions that disproportionately affects Latinos, the largest US minority group. Known NAFLD risk factors, like obesity, diabetes, poor diet, and genetic risk alleles, are more common in Latino populations, but we don’t fully understand how these factors contribute to Latinos’ high risks of developing NAFLD and its sequelae of non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. Moreover, prior study designs have been largely limited to case-control comparisons focused on clinically recognized disease. This represents only the “tip of the iceberg,” ignoring the large group with subclinical liver disease due to their abundance of risk factors. This proposal will examine host and bacteria produced metabolic products of diet in a large study sample of Latinos (Hispanic Community Health Study – Study of Latinos, N=16,415 adults from four US centers) with state-of-the-art imaging of subclinical liver fibrosis and steatosis. Based upon our results, diet and metabolome features that predict NAFLD may be translated into low-cost risk screening tests. By improving understanding of specific mechanisms, the study may also help to design interventions to prevent NAFLD, by diet modifications or pharmacologic or non-pharmacologic interventions.

摘要