Epidemiology of diet, metabolism and non-alcoholic fatty liver disease in Hispanic/Latino adults
西班牙裔/拉丁裔成人饮食、代谢和非酒精性脂肪肝的流行病学
基本信息
- 批准号:10735454
- 负责人:
- 金额:$ 77.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-15 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdultAffectBacteriaBiologicalBiological MarkersCirrhosisClinicalCohort StudiesCollaborationsConsumptionDataDiabetes MellitusDietDiet ModificationDisadvantagedDiseaseDisease PathwayEnsureEnvironmentEpidemiologyEssential Amino AcidsFatty LiverFatty acid glycerol estersFibrosisFructoseGastrointestinal tract structureGenetic DeterminismGenetic RiskGenetic VariationHigh PrevalenceHispanicHispanic Community Health Study/Study of LatinosHumanImageIndolesInflammationInfrastructureInterventionIntervention TrialKnowledgeLatin AmericanLatinoLatino PopulationLettersLifeLiteratureLiverLiver FibrosisLiver diseasesMagnetic Resonance ImagingMalignant neoplasm of liverMeasurementMeasuresMendelian randomizationMetabolicMetabolic DiseasesMetabolismMethodologyMethodsMinority GroupsModificationMonitorObesityPharmacotherapyPopulationPovertyPreventionPrevotellaProductionProtonsResearchResearch DesignRiskRisk FactorsRisk ReductionSample SizeSamplingSampling StudiesSerumShapesStratificationStudy of LatinosTestingTimeTranslatingTryptophanUnhealthy DietVisitagedbiobankburden of illnesscase controlcohortcontrast enhancedcostdata integrationdensitydiabetes riskdisorder preventiondisorder riskextracellulargenetic associationgut microbiomehigh riskimprovedinter-individual variationliver imaginglongitudinal analysismetabolomemetabolomicsmetagenomic sequencingmicrobiome sequencingmigrationminority subjectsnon-alcoholic fatty liver diseasenonalcoholic steatohepatitisnovelpharmacologicpreventpreventive interventionprimary outcomeprogression riskresponserisk variantscreeningsecondary outcomesexstudy populationsugartherapy design
项目摘要
Abstract
Nonalcoholic fatty liver disease (NAFLD) belongs to a cluster of metabolic conditions
that disproportionately affects Latinos, the largest US minority group. Known NAFLD
risk factors, like obesity, diabetes, poor diet, and genetic risk alleles, are more common
in Latino populations, but we don’t fully understand how these factors contribute to
Latinos’ high risks of developing NAFLD and its sequelae of non-alcoholic
steatohepatitis (NASH), cirrhosis, and liver cancer. Moreover, prior study designs have
been largely limited to case-control comparisons focused on clinically recognized
disease. This represents only the “tip of the iceberg,” ignoring the large group with
subclinical liver disease due to their abundance of risk factors. This proposal will
examine host and bacteria produced metabolic products of diet in a large study sample
of Latinos (Hispanic Community Health Study – Study of Latinos, N=16,415 adults from
four US centers) with state-of-the-art imaging of subclinical liver fibrosis and
steatosis. Based upon our results, diet and metabolome features that predict NAFLD
may be translated into low-cost risk screening tests. By improving understanding of
specific mechanisms, the study may also help to design interventions to prevent
NAFLD, by diet modifications or pharmacologic or non-pharmacologic interventions.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Robert D Burk其他文献
1296 FETAL ORIGIN OF MATERNAL SERUM ALPHA-FETOPROTEIN (AFP) DEMONSTRATED BY DNA-RNA HYBRIDIZATION
通过 DNA-RNA 杂交技术证明母体血清甲胎蛋白(AFP)的胎儿起源
- DOI:
10.1203/00006450-198504000-01320 - 发表时间:
1985-04-01 - 期刊:
- 影响因子:3.100
- 作者:
R Gordon Huteheon;Harold M Nltowsky;Sachiko Nakagawa;Robert D Burk - 通讯作者:
Robert D Burk
Oral HPV associated with differences in oral microbiota beta diversity and microbiota abundance.
口腔 HPV 与口腔微生物群 β 多样性和微生物群丰度的差异相关。
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:6.4
- 作者:
Yuehan Zhang;G. D’Souza;Carole Fakhry;Elaine O Bigelow;Mykhaylo Usyk;Robert D Burk;Ni Zhao - 通讯作者:
Ni Zhao
Association of meal timing with adiposity measures and gut microbiome characteristics in a cohort study: the Hispanic Community Health Study/Study of Latinos
一项队列研究中进餐时间与肥胖测量指标和肠道微生物组特征的关联:西班牙裔社区健康研究/拉丁裔研究
- DOI:
10.1016/j.ajcnut.2025.04.003 - 发表时间:
2025-06-01 - 期刊:
- 影响因子:6.900
- 作者:
Sarah K Alver;Brandilyn A Peters;Yasmin Mossavar-Rahmani;Qibin Qi;Amanda C McClain;Linda Van Horn;Robert D Burk;Robert C Kaplan - 通讯作者:
Robert C Kaplan
Robert D Burk的其他文献
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{{ truncateString('Robert D Burk', 18)}}的其他基金
Multi-omic signatures of gut dysbiosis and cardiovascular comorbidities associated with HIV infection
与 HIV 感染相关的肠道菌群失调和心血管合并症的多组学特征
- 批准号:
10762411 - 财政年份:2023
- 资助金额:
$ 77.27万 - 项目类别:
Impact of HIV, oral microbiome and mycobiome on oral HPV persistence
HIV、口腔微生物组和真菌组对口腔 HPV 持久性的影响
- 批准号:
10683323 - 财政年份:2022
- 资助金额:
$ 77.27万 - 项目类别:
Impact of HIV, oral microbiome and mycobiome on oral HPV persistence
HIV、口腔微生物组和真菌组对口腔 HPV 持久性的影响
- 批准号:
10534011 - 财政年份:2022
- 资助金额:
$ 77.27万 - 项目类别:
Investigations Into The Molecular Pathogenesis Of Cervical Glandular Neoplasias
宫颈腺瘤的分子发病机制研究
- 批准号:
10208823 - 财政年份:2020
- 资助金额:
$ 77.27万 - 项目类别:
Investigations Into The Molecular Pathogenesis Of Cervical Glandular Neoplasias
宫颈腺瘤的分子发病机制研究
- 批准号:
10652422 - 财政年份:2020
- 资助金额:
$ 77.27万 - 项目类别:
Investigations Into The Molecular Pathogenesis Of Cervical Glandular Neoplasias
宫颈腺瘤的分子发病机制研究
- 批准号:
9897227 - 财政年份:2020
- 资助金额:
$ 77.27万 - 项目类别:
Investigations Into The Molecular Pathogenesis Of Cervical Glandular Neoplasias
宫颈腺瘤的分子发病机制研究
- 批准号:
10443811 - 财政年份:2020
- 资助金额:
$ 77.27万 - 项目类别:
Next Generation of HPV and Cervical Cancer Research in HIV+ Women
HIV 女性中的下一代 HPV 和宫颈癌研究
- 批准号:
10203871 - 财政年份:2018
- 资助金额:
$ 77.27万 - 项目类别:
Next Generation of HPV and Cervical Cancer Research in HIV+ Women
HIV 女性中的下一代 HPV 和宫颈癌研究
- 批准号:
10440387 - 财政年份:2018
- 资助金额:
$ 77.27万 - 项目类别:
Epidemiology of the gut microbiome, prediabetes and diabetes in Latinos
拉丁裔肠道微生物组、糖尿病前期和糖尿病的流行病学
- 批准号:
9194787 - 财政年份:2016
- 资助金额:
$ 77.27万 - 项目类别:
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