mHealth-Facilitated Physical Activity Toward Health (mPATH) for Cognitive Function and Sleep in Low-Income Older Adults
移动健康促进健康体力活动 (mPATH) 促进低收入老年人的认知功能和睡眠
基本信息
- 批准号:10735622
- 负责人:
- 金额:$ 83.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2028-05-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdherenceAlzheimer&aposs DiseaseAlzheimer&aposs disease pathologyAlzheimer&aposs disease related dementiaAlzheimer&aposs disease riskAmyloidAmyloid beta-42Amyloid beta-ProteinBiologicalBiological MarkersCognitionCognitiveCommunitiesControl GroupsDementiaElderlyElectroencephalographyEmpirical ResearchEpisodic memoryExerciseGeneral PopulationGoalsHealthHomeHome visitationHourImpaired cognitionIndividualInequalityInterventionKnowledgeLightLocationLow incomeMeasuresMediatingMemoryMonitorMotivationNerve DegenerationOutcomeOutcome MeasureParticipantPatient Self-ReportPhysical activityPilot ProjectsPlasmaPlayPopulationRandomizedRandomized, Controlled TrialsResearchRisk FactorsRodentRoleScheduleSleepSleep disturbancesSleeplessnessSlow-Wave SleepStructureSubgroupSymptomsTelephoneTestingTimeTrainingWorkactigraphyage stratificationcognitive benefitscognitive functioncognitive testingcomparison controlcomputerizeddesignexecutive functionexercise interventionexperienceflexibilityhealth disparityhigh riskhigh risk populationimprovedinnovationlifestyle interventionmHealthneurofilamentphysical inactivitypoor sleepresponsesedentarysedentary lifestylesexsleep healthsleep spindlesocial disparitiestau Proteinstau-1telephone coachingtrendusabilitywearable device
项目摘要
PROJECT SUMMARY/ABSTRACT
Low-income older adults (LIOA) are a population at higher risk to develop Alzheimer's disease and related
dementias (ADRD) and sleep disturbances. Although empirical research suggests that physical activity
interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is
understudied in LIOA. The available evidence in LIOA suggests that LIOA experience unique barriers to
physical activity, more prevalent physical inactivity and sedentary behaviors. Since physical inactivity and
sedentary behaviors are independent risk factors that have synergistic harmful effects for cognitive function
and sleep, it is crucial to address them simultaneously to promote cognitive and sleep health in LIOA. The
growing wearable device and mobile Health (mHealth) provide an innovative approach to deliver individually
tailored physical activity interventions at home with flexible schedules to overcome barriers to physical activity
in LIOA. In addition, limited research has examined if physical activity interventions impact the individual’s
Amyloid/Tau/ Neurodegeneration (ATN) Alzheimer's disease biological state and whether physical activity may
promote cognition through impacting sleep and AD pathology. This randomized controlled trial is designed to
examine the immediate and sustaining efficacy of an mHealth-facilitated Physical Activity Toward Health
(mPATH) intervention on cognitive function and sleep in LIOA. mPATH is a personalized physical activity
intervention that includes personalized physical activity plans and training sessions, exercise at home by
following personalized exercise videos, and biweekly phone coaching over 24 weeks, supported by wearable
devices-enabled mHealth strategies. mHealth strategies and exercise videos will be used to support
participant’s physical activity during 6-12months. In the proposed study, we will randomize 176 community
dwelling LIOA with insomnia symptoms and without dementia to the mPATH or control group on a 1:1 ratio.
Randomization will be stratified by age, sex, and cognitive status. Specifically, we will (1) test the immediate (6-
month) and sustaining (12-month) effects of mPATH on cognitive function among LIOA, compared to control;
(2) test the immediate (6-month) and sustaining (12-month) effects of mPATH on sleep, compared to control;
and (3) explore the effect of mPATH on ATN biomarkers and potential mediating roles of sleep and ATN
biomarkers in mPATH’s effect on episodic memory.
项目概要/摘要
低收入老年人 (LIOA) 是患阿尔茨海默病及相关疾病的较高风险人群
痴呆症(ADRD)和睡眠障碍。尽管实证研究表明体力活动
一般来说,干预措施有利于老年人的认知和睡眠,体力活动的可能好处是
在LIOA实习。 LIOA 中的现有证据表明,LIOA 遇到独特的障碍
身体活动、更普遍的身体不活动和久坐行为。由于缺乏身体活动和
久坐行为是独立的危险因素,对认知功能具有协同有害影响
和睡眠,同时解决这些问题对于促进 LOA 的认知和睡眠健康至关重要。这
不断增长的可穿戴设备和移动健康 (mHealth) 提供了一种创新的方法来实现个性化服务
量身定制的在家体力活动干预措施具有灵活的时间表,以克服体力活动的障碍
在利奥阿。此外,有限的研究还检验了身体活动干预是否会影响个人的
淀粉样蛋白/Tau/神经退行性变 (ATN) 阿尔茨海默病的生物学状态以及体力活动是否可能
通过影响睡眠和 AD 病理来促进认知。这项随机对照试验旨在
检查移动健康促进的身体活动对健康的直接和持续功效
(mPATH) 对 LOA 认知功能和睡眠的干预。 mPATH 是一项个性化的身体活动
干预措施包括个性化的身体活动计划和培训课程、在家锻炼
在可穿戴设备的支持下,遵循个性化锻炼视频以及 24 周内每两周一次的电话辅导
设备支持的移动医疗策略。移动健康策略和锻炼视频将用于支持
参与者在 6-12 个月内的体力活动。在拟议的研究中,我们将随机分组 176 个社区
具有失眠症状且无痴呆的居住 LIOA 与 mPATH 组或对照组按 1:1 的比例进行比较。
随机分组将按年龄、性别和认知状态进行分层。具体来说,我们将 (1) 测试立即 (6-
与对照组相比,mPATH 对 LOA 认知功能的影响(12 个月)和持续(12 个月);
(2) 与对照相比,测试 mPATH 对睡眠的即时(6 个月)和持续(12 个月)影响;
(3)探讨mPATH对ATN生物标志物的影响以及睡眠和ATN的潜在中介作用
mPATH 中的生物标志物对情景记忆的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Junxin Li其他文献
Junxin Li的其他文献
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{{ truncateString('Junxin Li', 18)}}的其他基金
The power of 40 Hz sound/music for older adults with mild cognitive impairment
40 Hz 声音/音乐对患有轻度认知障碍的老年人的力量
- 批准号:
10683238 - 财政年份:2022
- 资助金额:
$ 83.36万 - 项目类别:
The power of 40 Hz sound/music for older adults with mild cognitive impairment
40 Hz 声音/音乐对患有轻度认知障碍的老年人的力量
- 批准号:
10509893 - 财政年份:2022
- 资助金额:
$ 83.36万 - 项目类别:
A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults
改善久坐老年人身体活动、睡眠和认知的个性化行为干预
- 批准号:
9808108 - 财政年份:2019
- 资助金额:
$ 83.36万 - 项目类别:
A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults
改善久坐老年人身体活动、睡眠和认知的个性化行为干预
- 批准号:
10163919 - 财政年份:2019
- 资助金额:
$ 83.36万 - 项目类别:
A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults
改善久坐老年人身体活动、睡眠和认知的个性化行为干预
- 批准号:
9973230 - 财政年份:2019
- 资助金额:
$ 83.36万 - 项目类别:
A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults
改善久坐老年人身体活动、睡眠和认知的个性化行为干预
- 批准号:
9313511 - 财政年份:2017
- 资助金额:
$ 83.36万 - 项目类别:
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