mHealth-Facilitated Physical Activity Toward Health (mPATH) for Cognitive Function and Sleep in Low-Income Older Adults

移动健康促进健康体力活动 (mPATH) 促进低收入老年人的认知功能和睡眠

• 批准号: 10735622
• 负责人: Junxin Li
• 金额: $ 83.36万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735622
• 关键词: Address; Adherence; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amyloid; Amyloid beta-42; Amyloid beta-Protein; Biological; Biological Markers; Cognition; Cognitive; Communities; Control Groups; Dementia; Elderly; Electroencephalography; Empirical Research; Episodic memory; Exercise; General Population; Goals; Health; Home; Home visitation; Hour; Impaired cognition; Individual; Inequality; Intervention; Knowledge; Light; Location; Low income; Measures; Mediating; Memory; Monitor; Motivation; Nerve Degeneration; Outcome; Outcome Measure; Participant; Patient Self-Report; Physical activity; Pilot Projects; Plasma; Play; Population; Randomized; Randomized, Controlled Trials; Research; Risk Factors; Rodent; Role; Schedule; Sleep; Sleep disturbances; Sleeplessness; Slow-Wave Sleep; Structure; Subgroup; Symptoms; Telephone; Testing; Time; Training; Work; actigraphy; age stratification; cognitive benefits; cognitive function; cognitive testing; comparison control; computerized; design; executive function; exercise intervention; experience; flexibility; health disparity; high risk; high risk population; improved; innovation; lifestyle intervention; mHealth; neurofilament; physical inactivity; poor sleep; response; sedentary; sedentary lifestyle; sex; sleep health; sleep spindle; social disparities; tau Proteins; tau-1; telephone coaching; trend; usability; wearable device

PROJECT SUMMARY/ABSTRACT Low-income older adults (LIOA) are a population at higher risk to develop Alzheimer's disease and related dementias (ADRD) and sleep disturbances. Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in LIOA. The available evidence in LIOA suggests that LIOA experience unique barriers to physical activity, more prevalent physical inactivity and sedentary behaviors. Since physical inactivity and sedentary behaviors are independent risk factors that have synergistic harmful effects for cognitive function and sleep, it is crucial to address them simultaneously to promote cognitive and sleep health in LIOA. The growing wearable device and mobile Health (mHealth) provide an innovative approach to deliver individually tailored physical activity interventions at home with flexible schedules to overcome barriers to physical activity in LIOA. In addition, limited research has examined if physical activity interventions impact the individual’s Amyloid/Tau/ Neurodegeneration (ATN) Alzheimer's disease biological state and whether physical activity may promote cognition through impacting sleep and AD pathology. This randomized controlled trial is designed to examine the immediate and sustaining efficacy of an mHealth-facilitated Physical Activity Toward Health (mPATH) intervention on cognitive function and sleep in LIOA. mPATH is a personalized physical activity intervention that includes personalized physical activity plans and training sessions, exercise at home by following personalized exercise videos, and biweekly phone coaching over 24 weeks, supported by wearable devices-enabled mHealth strategies. mHealth strategies and exercise videos will be used to support participant’s physical activity during 6-12months. In the proposed study, we will randomize 176 community dwelling LIOA with insomnia symptoms and without dementia to the mPATH or control group on a 1:1 ratio. Randomization will be stratified by age, sex, and cognitive status. Specifically, we will (1) test the immediate (6- month) and sustaining (12-month) effects of mPATH on cognitive function among LIOA, compared to control; (2) test the immediate (6-month) and sustaining (12-month) effects of mPATH on sleep, compared to control; and (3) explore the effect of mPATH on ATN biomarkers and potential mediating roles of sleep and ATN biomarkers in mPATH’s effect on episodic memory.

项目摘要/摘要 低收入老年人（LIOA）是发展阿尔茨海默氏病及相关风险的人口 痴呆症（ADRD）和睡眠障碍。尽管实证研究表明体育锻炼 一般而言，干预措施使老年人的认知和睡眠受益，体育锻炼的可能好处是 在lioa进行了研究。 LIOA的可用证据表明，LIOA经历了独特的障碍 体育锻炼，更普遍的身体不活动和久坐的行为。由于身体不活动和 久坐行为是对认知功能具有协同有害影响的独立风险因素 睡眠，仅仅为了促进LIOA的认知和睡眠健康而言，至关重要。 增长可穿戴设备和移动健康（MHealth）提供了一种创新的方法来单独交付 在家中量身定制的体育锻炼干预措施具有灵活的时间表以克服体育锻炼的障碍 在lioa。此外，有限的研究已经检查了体育锻炼干预是否影响个人的 淀粉样蛋白/ tau/神经变性（ATN）阿尔茨海默氏病生物学状态以及身体活动是否可以 通过影响睡眠和AD病理来促进认知。这项随机对照试验设计为 检查针对健康的体育锻炼的直接和持续效率 （mpath）干预LIOA认知功能和睡眠。 MPATH是个性化的体育锻炼 包括个性化的体育锻炼计划和培训课程，在家锻炼的干预措施 按照个性化的练习视频，并在24周内双周的电话指导，并在可穿戴设备上支持 支持设备的MHealth策略。 MHealth策略和锻炼视频将用于支持 参与者在6-12个月内的体育锻炼。在拟议的研究中，我们将随机分别176个社区 居住有失眠症状的LIOA，并以1：1的比例对MPATH或对照组痴呆。 随机化将按年龄，性别和认知状况进行分层。具体来说，我们将（1）立即测试（6- 与对照组相比，MPATH对LIOA认知功能的持续影响（12个月）的持续（12个月）； （2）与对照相比，测试MPATH对睡眠的直接（6个月）和持续（12个月）的影响； （3）探索MPATH对ATN生物标志物的影响以及潜在的睡眠和ATN的作用 Mpath对情节记忆的影响。