A Personalized Behavioral Intervention to Improve Physical Activity, Sleep and Cognition in Sedentary Older Adults

改善久坐老年人身体活动、睡眠和认知的个性化行为干预

• 批准号: 9808108
• 负责人: Junxin Li
• 金额: $ 24.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9808108
• 关键词: Accelerometer; Achievement; Affect; Aging; Attention; Behavior Therapy; Biological Markers; C-reactive protein; Characteristics; Circadian Rhythms; Cognition; Cognitive; Complex; Control Groups; Dementia; Devices; Effectiveness; Elderly; Ensure; Exercise; Foundations; Frequencies; Future; Goals; Health; Heart Rate; Impaired cognition; Individual; Inflammatory; Interleukin-1 beta; Interleukin-6; Intervention; Intervention Studies; Learning; Longitudinal cohort; Mediating; Mentors; Mission; Monitor; Napping; National Institute of Nursing Research; Outcome; Outcome Study; Participant; Pathway interactions; Phase; Physical Exercise; Physical activity; Pilot Projects; Preparation; Public Health; Randomized Controlled Trials; Reporting; Research Personnel; Retrospective Studies; Risk Factors; Serum; Short-Term Memory; Sleep; Structure; TNF gene; Technology; Testing; Time; Training; United States; Work; Wrist; base; behavior change; career; career development; circadian; cognitive benefits; cognitive function; cognitive performance; cohort; cytokine; exercise intervention; follow-up; healthy aging; improved; improvement on sleep; innovation; insight; laboratory experience; novel; older men; older women; physical conditioning; preservation; processing speed; prospective; prototype; sedentary; sedentary lifestyle; smart watch; vigilance; wearable device

PROJECT SUMMARY/ABSTRACT The proposed project aims to identify the optimal features of daytime napping and physical activity for cognition in older adults (K99) and examine the effects of an innovative, personalized behavioral intervention on promoting physical activity, healthy napping, sleep and cognitive function in sedentary older adults (R00). In the K99 phase, to ensure the successful completion of the R00 project and facilitate the achievement of my career development goals, I will follow an intensive training plan that incorporates courses, laboratory training, mentoring, and structured activities. In addition, a retrospective study will be conducted using two large longitudinal cohorts of older adults in the United States to examine the associations of daytime physical activity and nocturnal sleep with cognitive decline over 4-6 years. The K99 study will examine: 1) baseline associations of napping characteristics, physical activity and nocturnal sleep duration with cognition; 2) whether baseline napping, physical activity and nocturnal sleep duration predict cognitive decline at the 4-6 year follow-up; and 3) relationships between changes in physical activity and nocturnal sleep duration and changes in cognitive function at follow-up. Building off the K99, in the R00 phase, a randomized controlled trial will be conducted in older adults (without dementia) with both sedentary lifestyle and nocturnal sleep complaints to examine the effectiveness of a 24-week personalized behavioral intervention implemented with smartwatch technology on promoting physical activity, nocturnal sleep, and cognition compared against a control group; we have successfully tested this in a pilot study. Serum inflammatory biomarkers will be assessed to explore hypothesized mechanisms for associations among the study outcomes. In order to optimize outcomes at the subject level, a personalized physical activity plan will be calculated based on the individual’s characteristics, personal circadian rhythm at baseline, and the optimal characteristics of napping and physical activity that were identified in the K99 phase. The R00 study will examine: 1) whether the intervention increases participants’ non-nap period physical activity, optimizes napping duration, and enhances nocturnal sleep; 2) whether the intervention improves participants’ overall cognitive performance; 3) whether the relationship between the study intervention and cognitive performance is mediated by changes in physical activity, healthy nap duration, and nocturnal sleep duration; and 4) (exploratory aim) if the proposed intervention changes serum inflammatory biomarkers, including cytokines (IL-6, IL-1ß, TNF-α) and C-reactive protein, and whether these biomarkers relate to changes in physical activity, sleep, and cognitive function. Upon completion, this proposal will provide important insights on the optimal features of physical activity and napping for cognitive function. The proposed intervention may provide a novel way for older adults to optimize wellness and achieve active, healthy lives while aging, a key theme of the National Institute of Nursing Research in its mission to enhance public health. It will also build a strong foundation for my future career as an independent researcher.

项目总结/摘要 该项目旨在确定白天小睡和身体活动对认知的最佳特征 在老年人（K99），并检查一个创新的，个性化的行为干预的影响， 促进久坐老年人的身体活动、健康午睡、睡眠和认知功能（R 00）。在 K99阶段，以确保R 00项目的顺利完成，并促进实现我的 职业发展目标，我将遵循强化培训计划，包括课程，实验室培训， 指导和结构化活动。此外，还将使用两个大型 美国老年人的纵向队列研究，以检查白天体力活动的相关性 夜间睡眠和认知能力下降超过4-6年。K99研究将检查：1）基线相关性 午睡特征、体力活动和夜间睡眠持续时间与认知的关系; 2）基线是否 午睡、体力活动和夜间睡眠持续时间可预测4-6年随访时的认知能力下降; 3） 体力活动和夜间睡眠持续时间的变化与认知功能变化之间的关系 功能在后续。在K99的基础上，在R 00阶段，将进行一项随机对照试验， 老年人（无痴呆症）久坐不动的生活方式和夜间睡眠投诉，以检查 使用智能手表技术实施的24周个性化行为干预的有效性 与对照组相比，促进身体活动、夜间睡眠和认知;我们有 在一项试点研究中成功地测试了这一点。将评估血清炎症生物标志物，以探索 研究结果之间关联的假设机制。为了优化成果， 受试者水平，个性化的身体活动计划将根据个人的特点计算， 在基线时的个人昼夜节律，以及午睡和体力活动的最佳特征， 在K99阶段被发现。R 00研究将检查：1）干预是否增加 参与者的非午睡期体力活动，优化午睡时间，并增强夜间睡眠; 2） 干预是否改善了参与者的整体认知表现; 3） 研究干预和认知表现之间的关系是由身体活动、健康 午睡持续时间和夜间睡眠持续时间;以及4）（探索性目标）如果拟议的干预措施发生变化 血清炎症生物标志物，包括细胞因子（IL-6、IL-1 β、TNF-α）和C反应蛋白，以及是否 这些生物标志物与身体活动、睡眠和认知功能的变化有关。完成后，这 该提案将为身体活动和午睡对认知的最佳特征提供重要见解 功能拟议的干预措施可能为老年人提供一种新的方式来优化健康， 积极，健康的生活，而老龄化，一个关键的主题，国家护理研究所在其使命， 加强公众健康。这也将为我未来作为一名独立研究人员的职业生涯奠定坚实的基础。