The power of 40 Hz sound/music for older adults with mild cognitive impairment

40 Hz 声音/音乐对患有轻度认知障碍的老年人的力量

• 批准号: 10509893
• 负责人: Junxin Li
• 金额: $ 24.56万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10509893
• 关键词: Acoustic Stimulation; Acute; Adherence; Affect; Age; Alzheimer' s Disease; American; Amyloid beta-Protein; Animal Experimentation; Animals; Auditory; Auditory area; Back; Clinical; Cognition; Cognitive; Communities; Cross-Over Trials; Data; Development; Elderly; Electroencephalogram; Electroencephalography; Esthetics; Evaluation; Exposure to; Feasibility Studies; Frequencies; Future; Goals; Health; Hippocampus (Brain); Hour; Human; Impaired cognition; Individual; Intervention; Interview; Libraries; Measures; Music; Neurons; Parietal; Participant; Pathology; Persons; Procedures; Quality of life; Randomized; Research; Scalp structure; Stimulus; Structure; Time; Training; Translating; amnestic mild cognitive impairment; cognitive benefits; cognitive enhancement; cognitive function; cohort; computerized; density; experience; feasibility testing; high risk population; improved; innovation; mild cognitive impairment; mouse model; neural circuit; novel; prevent; primary outcome; relating to nervous system; slow potential; sound; spatial memory; tau Proteins

PROJECT SUMMARY/ABSTRACT There are limited treatment options for Alzheimer’s disease dementia (AD) and its associated progressive cognitive impairment, calling for target interventions that potentially slow the progression of cognitive decline, prevent, or delay the onset of AD in individuals with mild cognitive impairment (MCI). One promising treatment possibility is auditory stimulation at gamma frequencies. Emerging research suggests that 40 Hz sound may stimulate gamma oscillations and enhance cognitive function in older adults, but much remains unknown. Our group has created a novel 40 Hz music intervention, which may provide similar gamma entrainment, and is likely more aesthetically pleasing, allowing an evaluation of the long-term use of 40 Hz stimulation on cognitive function. We will conduct a 3-treatment 3-period pilot crossover trial to test the feasibility and preliminary efficacy of 40 Hz music (Condition A), 40 Hz sound (Condition B) and preferred music (Condition C) on neural gamma activity and cognitive function in 30 community-dwelling older adults with amnestic MCI. The participants will be randomized to three groups with different sequences of exposure to all three conditions. To examine the effect of the three conditions on gamma entrainment, participants will first undergo an acute music/sound stimulation session and a scalp electroencephalogram (EEG) will be recorded during the session. Next, the participants will be instructed to listen to the assigned sequence of conditions, with each condition for four weeks (1 h/day, 5 days/week). There will be a 10-day wash-out break between each condition. Semi- structured interviews will be conducted after completing each condition. The specific aims are as follows: Aim 1: Evaluate the feasibility of the study and the three conditions: 40 Hz music, 40 Hz sound, and Preferred Music in older adults with MCI. Qualitative data will be used to understand the participant's experience and acceptability of the three conditions; Aim 2: Determine the preliminary efficacy of 40 Hz music for four weeks on cognitive function compared with 40 Hz sound and Preferred Music; Aim 3: Evaluate the effect of 40 Hz music and 40 Hz sound on gamma entrainment during the acute stimulation session. This study will be the first to test the feasibility and preliminary efficacy of innovative 40 Hz music and 40 Hz sound interventions on cognitive function in older adults with MCI, a high-risk population for AD. Findings from this study will provide important evidence for future development, selection, evaluation, and implementation of music/sound interventions for cognitive health in older adults with MCI.

项目摘要/摘要 阿尔茨海默病痴呆(AD)及其相关的进行性疾病的治疗选择有限 认知障碍，需要目标干预，潜在地减缓认知下降的进展， 预防或推迟轻度认知障碍(MCI)患者的AD发病。一种有希望的治疗方法 可能是伽马频率的听觉刺激。新的研究表明，40赫兹的声音可能 刺激老年人的伽马振荡并增强认知功能，但仍有许多未知之处。我们的 该小组已经创造了一种新的40赫兹音乐干预，它可能提供类似的伽马夹带，并且是 可能更美观，允许评估长期使用40赫兹刺激对认知的影响 功能。我们将进行3个疗程的3个阶段的试点交叉试验，以测试其可行性和初步 40赫兹音乐(状态A)、40赫兹声音(状态B)和首选音乐(状态C)对神经的影响 30例社区老年遗忘型MCI患者的伽马活动和认知功能。这个 参与者将被随机分成三组，每组在所有三种情况下的暴露顺序不同。至 检查三种情况对伽马夹带的影响，参与者将首先经历急性 在训练过程中将记录音乐/声音刺激和头皮脑电。 接下来，将指示参与者听取分配的条件序列，每个条件 四周(每天1小时，每周5天)。每种情况之间将有10天的淘汰期。半- 在完成每个条件后，将进行结构化面试。具体目标如下：目标 1：评估研究的可行性和三种条件：40赫兹的音乐、40赫兹的声音和首选 患有MCI的老年人的音乐。定性数据将用于了解学员的体验和 三种条件的可接受性；目标2：确定40赫兹音乐的初步疗效，为期四周 40赫兹声音和首选音乐对认知功能的影响；目标3：评估40赫兹的效果 音乐和40赫兹的声音在急性刺激过程中的伽马夹带。这项研究将是第一次 为了测试创新的40赫兹音乐和40赫兹声音干预的可行性和初步效果 老年痴呆症高危人群MCI患者的认知功能。这项研究的结果将提供 音乐/声音未来发展、选择、评估和实施的重要证据 对老年MCI患者认知健康的干预。