The power of 40 Hz sound/music for older adults with mild cognitive impairment

项目概要/摘要 阿尔茨海默氏病痴呆 (AD) 及其相关进行性痴呆的治疗选择有限 认知障碍，呼吁采取有针对性的干预措施，以减缓认知能力下降的进程， 预防或延缓患有轻度认知障碍 (MCI) 的个体 AD 的发作。一种有希望的治疗方法 可能性是伽马频率的听觉刺激。新兴研究表明 40 Hz 的声音可能 刺激伽马振荡并增强老年人的认知功能，但仍有很多未知之处。我们的 小组创造了一种新颖的 40 Hz 音乐干预，它可以提供类似的伽马夹带，并且是 可能更美观，可以评估长期使用 40 Hz 刺激对认知的影响 功能。我们将进行3个治疗3个周期的试点交叉试验，以测试可行性和初步结果 40 Hz 音乐（条件 A）、40 Hz 声音（条件 B）和偏好音乐（条件 C）对神经的功效 30 名患有遗忘性 MCI 的社区老年人的伽马活性和认知功能。的 参与者将被随机分为三组，并以不同的顺序接触所有三种条件。至 检查三种条件对伽玛夹带的影响，参与者将首先经历急性 会议期间将记录音乐/声音刺激会议和头皮脑电图（EEG）。 接下来，参与者将被指示聆听指定的条件序列，每个条件 四个星期（每天 1 小时，每周 5 天）。每种情况之间会有 10 天的休息时间。半 完成每个条件后将进行结构化面试。具体目标如下： 目标 1：评估研究的可行性以及三个条件：40Hz音乐、40Hz声音、首选 患有 MCI 的老年人的音乐。定性数据将用于了解参与者的经验和 这三个条件的可接受性；目标2：确定40赫兹音乐四个星期的初步功效 与 40 Hz 声音和首选音乐相比，对认知功能的影响；目标 3：评估 40 Hz 的效果 在急性刺激期间，音乐和 40 Hz 声音对伽马夹带。这项研究将是第一个 测试创新的 40 Hz 音乐和 40 Hz 声音干预的可行性和初步效果 患有 MCI 的老年人（AD 的高危人群）的认知功能。这项研究的结果将提供 未来音乐/声音的开发、选择、评估和实施的重要证据 对患有 MCI 的老年人进行认知健康干预。

PROJECT SUMMARY/ABSTRACT There are limited treatment options for Alzheimer’s disease dementia (AD) and its associated progressive cognitive impairment, calling for target interventions that potentially slow the progression of cognitive decline, prevent, or delay the onset of AD in individuals with mild cognitive impairment (MCI). One promising treatment possibility is auditory stimulation at gamma frequencies. Emerging research suggests that 40 Hz sound may stimulate gamma oscillations and enhance cognitive function in older adults, but much remains unknown. Our group has created a novel 40 Hz music intervention, which may provide similar gamma entrainment, and is likely more aesthetically pleasing, allowing an evaluation of the long-term use of 40 Hz stimulation on cognitive function. We will conduct a 3-treatment 3-period pilot crossover trial to test the feasibility and preliminary efficacy of 40 Hz music (Condition A), 40 Hz sound (Condition B) and preferred music (Condition C) on neural gamma activity and cognitive function in 30 community-dwelling older adults with amnestic MCI. The participants will be randomized to three groups with different sequences of exposure to all three conditions. To examine the effect of the three conditions on gamma entrainment, participants will first undergo an acute music/sound stimulation session and a scalp electroencephalogram (EEG) will be recorded during the session. Next, the participants will be instructed to listen to the assigned sequence of conditions, with each condition for four weeks (1 h/day, 5 days/week). There will be a 10-day wash-out break between each condition. Semi- structured interviews will be conducted after completing each condition. The specific aims are as follows: Aim 1: Evaluate the feasibility of the study and the three conditions: 40 Hz music, 40 Hz sound, and Preferred Music in older adults with MCI. Qualitative data will be used to understand the participant's experience and acceptability of the three conditions; Aim 2: Determine the preliminary efficacy of 40 Hz music for four weeks on cognitive function compared with 40 Hz sound and Preferred Music; Aim 3: Evaluate the effect of 40 Hz music and 40 Hz sound on gamma entrainment during the acute stimulation session. This study will be the first to test the feasibility and preliminary efficacy of innovative 40 Hz music and 40 Hz sound interventions on cognitive function in older adults with MCI, a high-risk population for AD. Findings from this study will provide important evidence for future development, selection, evaluation, and implementation of music/sound interventions for cognitive health in older adults with MCI.