Examining the Impact of Stress on the Emotionally Reinforcing Properties of Alcohol in Heavy Social Drinkers: A Multimodal Investigation Integrating Laboratory and Ambulatory Methods

检查压力对大量社交饮酒者的酒精情绪强化特性的影响：结合实验室和流动方法的多模式调查

• 批准号: 10735704
• 负责人: Catharine Fairbairn
• 金额: $ 52.32万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735704
• 关键词: Address; Alcohol abuse; Alcohol consumption; Alcohols; Automobile Driving; Beverages; Biological Markers; Biosensor; Brain; Brain imaging; Clinical; Consumption; Early identification; Electroencephalography; Elements; Emotional; Etiology; Genetic Complementation Test; Grant; Harm Reduction; Health Policy; Heavy Drinking; Image; Individual; Intervention; Investigation; Laboratories; Life; Link; Literature; Measures; Methodology; Methods; Modality; Modeling; Moods; Nature; Participant; Pattern; Persons; Photography; Prevention; Prevention program; Process; Property; Psychological reinforcement; Public Health; Randomized; Relapse; Reporting; Research; Research Personnel; Rewards; Risk; Role; Science; Scientist; Severities; Shock; Social Environment; Social Interaction; Social Processes; Speech; Stimulus; Stress; Symptoms; Technology; Thalamencephalon; Theoretical model; Time; Work; addiction; alcohol effect; alcohol reinforcement; alcohol reward; alcohol risk; alcohol use disorder; comparative; contextual factors; design; disorder risk; drinking; drinking behavior; experimental study; hazardous drinking; high risk; imaging modality; improved; in vivo; indexing; innovation; laboratory experiment; multidisciplinary; multimodality; neural; neurobehavioral; neuroimaging; novel; programs; relapse risk; response; social; social engagement; stressor; tool

Alcohol’s ability to improve mood in the face of stress is among its most prized reinforcing properties, long held by researchers to be of critical importance for the understanding of the etiology of alcohol use disorder (AUD). Drinkers overwhelmingly report that the mood-enhancement they gain from alcohol is most pronounced in the context of stress, and individuals who report higher levels of stress relief from alcohol are at risk for developing AUD. But attempts to capture this key element of alcohol reinforcement using experimental methods have yielded strikingly inconsistent results. One remarkable feature of the extant experimental literature is that, in attempting to capture alcohol’s stress-relieving effects, researchers have strayed far outside the range of stressors typically encountered in everyday drinking settings, contexts that are overwhelmingly social in nature. Here, we harness the power of stressful stimuli that emerge naturally within everyday contexts, focusing on social novelty as a compound stress-trigger ubiquitous to real-world heavy drinking settings. Building on our prior work indicating enhanced alcohol reward in novel compared with familiar social context, together with pilot findings pointing to potential links between social novelty and hazardous patterns of drinking, we draw on innovative methods and measures to further build the understanding of social-contextual factors driving consumption. Specifically, we leverage multi-participant neuroimaging recording arrays (i.e., hyperscanning) to pinpoint both inter- and intra-brain processes underlying alcohol reinforcement, a mechanistic analysis we complement with ambulatory and longitudinal methods for tracing real world patterns of consumption. Participants (N=240) will attend two experimental laboratory sessions, on one of which they will consume alcohol and on the other a control beverage. Participants will complete tasks in the company of either a stranger or familiar individual while EEG is recorded from both participants simultaneously. Participants will also engage in a 14-day ambulatory assessment period during which drinking will be assessed continuously via transdermal alcohol biosensor while social context is explored via in-vivo photographic image- capture methods. Finally, longitudinal changes in hazardous drinking and AUD symptoms will be assessed for 24 months post-baseline. The aims of the project are to: 1) Explore diminished threat sensitivity and enhanced social engagement as mechanisms driving alcohol reward in novel social context; 2) Examine social reward- attentive processes as well as social-contextual novelty as predictors of hazardous drinking and AUD. The proposed research contributes to the understanding of AUD by addressing one of the most fundamental questions in the alcohol literature—the question of why people drink. Further, representing a critical step towards building a contextually-informed, mechanistically precise model of AUD etiology, the proposed study might have a variety of key implications including for refining harm-reduction and prevention programs, reducing rates of relapse, informing public health policy, and the early identification of those at risk.

长期以来，酒精在压力面前改善情绪的能力是其最宝贵的强化特性之一 研究人员认为，这对于了解酒精使用障碍(AUD)的病因至关重要。 绝大多数饮酒者报告说，他们从酒精中获得的情绪改善在 压力的背景下，报告戒酒后压力释放水平较高的人有患上 澳元。但是使用实验方法捕捉酒精强化的这一关键因素的尝试已经 产生了惊人的不一致的结果。现存的实验文献的一个显著特点是，在 为了捕捉酒精缓解压力的作用，研究人员已经偏离了 通常在日常饮酒环境中遇到的压力，压倒性的社交环境 大自然。在这里，我们利用在日常生活中自然出现的应激刺激的力量， 将社交新鲜感作为一种复合压力触发因素，在现实世界的酗酒环境中随处可见。 基于我们之前的工作，与熟悉的社会背景相比，小说中的酒精奖励增加了， 以及试点研究结果，指出了社会新颖性和危险模式之间的潜在联系 饮酒，我们借鉴创新的方法和措施，进一步建立对社会语境的理解 推动消费的因素。具体地说，我们利用多参与者神经成像记录阵列(即， 超扫描)，以确定酒精强化背后的大脑间和脑内过程， 我们用动态和纵向方法补充机械分析来追踪真实世界的模式 消费的影响。参与者(N=240)将参加两次实验实验室会议，其中一次他们 一边喝酒精，一边喝对照饮料。学员将在以下人员的陪同下完成任务 无论是陌生人还是熟悉的人，同时记录两个参与者的脑电。 参与者还将进行为期14天的动态评估，在此期间将对饮酒情况进行评估 通过透皮酒精生物传感器持续进行，同时通过活体摄影图像探索社会背景- 捕获方法。最后，将评估危险饮酒和AUD症状的纵向变化 基线后24个月。该项目的目标是：1)探索降低威胁敏感度和增强 在新的社会背景下，社会投入作为驱动酒精奖励的机制；2)考察社会奖励- 注意的过程以及社会背景的新颖性是危险饮酒和AUD的预测因素。这个 拟议的研究通过解决最基本的问题之一来帮助理解澳元 酒精文献中的问题--人们为什么喝酒的问题。此外，代表着关键的一步 这项拟议的研究旨在建立一个根据背景信息、机械精确的AUD病因学模型 可能会有各种关键影响，包括完善减少伤害和预防计划， 降低复发率，为公共卫生政策提供信息，并及早识别有风险的人。

项目成果

Mixing Misery and Gin: The Effect of Alcohol Administration on Ostracism Response.

• DOI: 10.1177/01461672211038450
• 发表时间: 2022-08
• 期刊: Personality & social psychology bulletin
• 影响因子: 4
• 作者: Fairbairn CE;Creswell KG;Hales AH;Williams KD;Wilkins KV
• 通讯作者: Wilkins KV

Using machine learning for real-time BAC estimation from a new-generation transdermal biosensor in the laboratory.

• DOI: 10.1016/j.drugalcdep.2020.108205
• 发表时间: 2020-11-01
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Fairbairn CE;Kang D;Bosch N
• 通讯作者: Bosch N

A new generation of transdermal alcohol biosensing technology: practical applications, machine -learning analytics and questions for future research.

• DOI: 10.1111/add.15523
• 发表时间: 2021-10
• 期刊: Addiction (Abingdon, England)
• 作者: Fairbairn CE;Bosch N
• 通讯作者: Bosch N

Examining new-generation transdermal alcohol biosensor performance across laboratory and field contexts.

在实验室和现场环境中检查新一代透皮酒精生物传感器的性能。

• DOI: 10.1111/acer.14977
• 发表时间: 2023
• 期刊: Alcohol, clinical & experimental research
• 作者: Ariss,Talia;Fairbairn,CatharineE;Bosch,Nigel
• 通讯作者: Bosch,Nigel

Alcohol narrows physical distance between strangers.

• DOI: 10.1073/pnas.2101937118
• 发表时间: 2021-05-18
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Gurrieri L;Fairbairn CE;Sayette MA;Bosch N
• 通讯作者: Bosch N