Space Optimization, Allergen Mitigation, and Improved Microenvironmental Conditions in a Shared Use Animal Facility at Florida State University

佛罗里达州立大学共享动物设施的空间优化、过敏原缓解和改善微环境条件

• 批准号: 10735627
• 负责人: William Allen Hill
• 金额: $ 34.93万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10735627
• 关键词: Agriculture; Air; Allergens; Ammonia; Animal Welfare; Animals; Area; Biological Sciences; Biomedical Research; Carbon Dioxide; Data Science; Engineering; Enrollment; Ensure; Environment; Exposure to; Faculty; Florida; Funding; Future; Goals; Growth; Health Personnel; Human Resources; Humidity; Immunocompromised Host; Individual; Infrastructure; Investigation; Laboratory Animals; Location; Mechanics; Medical Research; Medical Students; Mentors; Modernization; Modification; Monitor; Mus; Occupational; Occupational Health; Oxygen; Positioning Attribute; Publishing; Rattus; Request for Proposals; Research; Research Personnel; Risk; Rodent; Safety; Sampling; Side; System; Technology; Temperature; Translating; United States National Institutes of Health; Universities; Work; air sampling; animal care; animal facility; animal resource; effectiveness evaluation; effectiveness testing; experience; health data; improved; innovation; programs; research facility; success; tenure track; ventilation

PROJECT SUMMARY This proposal requests funds to acquire Tecniplast Emerald EM500 individually ventilated caging (IVC) systems to modernize and incorporate the latest IVC technology into a shared use vivarium at Florida State University (FSU). The FSU Animal Care and Use Program is poised to experience unprecedented growth as a result of the University President’s bold and ambitious agenda to increase annual research funding from $328M to $500M by building capacity in life sciences, medical research, and health data sciences and by hiring approximately 170 new, full- time, tenure-track faculty. The open-top and microisolator caging used program-wide cannot support the anticipated growth within existing facilities. Moreover, the expansion of the FSU research enterprise will undoubtedly translate into an increase in work with immunocompromised rodents and hazardous agents, which due to the lack of appropriate engineering controls, the University is presently ill-equipped to handle. Additionally, recent consultancy studies commissioned by the FSU Office of the Vice President for Research (OVPR) have identified occupational health concerns, specifically personnel exposure to laboratory animal allergens associated with the widespread use of open-top caging. The goal of this project is to acquire six single-sided mouse racks, three double-sided mouse racks, and one single-sided rat rack for the Biomedical Research Facility (BRF) vivarium, which, in combination, will provide 1,092 cage spaces for rodents and increase the mouse cage holding capacity of the vivarium by 162%. In addition to space optimization, the IVC technology requested is expected to mitigate occupational allergen exposure risks, provide appropriate engineering controls for work with immunocompromised rodents and hazardous agents, and improve microenvironmental conditions for FSU animal resources. The operational innovation and benefits to personnel health and safety and animal welfare achieved by the success of this proposal will uniquely position FSU and LAR to meet the demands of a burgeoning research enterprise and the needs of current and future NIH-funded investigators.

项目总结 这项提议要求资金收购Tecniplast Emerald EM500单独通风 笼子(IVC)系统，以实现现代化并将最新的IVC技术融入共享使用 佛罗里达州立大学(FSU)的间隔室。佛罗里达州立大学动物保护和利用项目即将 经历前所未有的增长，这是大学校长大胆和雄心勃勃的结果 通过生命能力建设将年度研究资金从3.28亿美元增加到5亿美元的议程 科学、医学研究和健康数据科学，并通过招聘约170名新的、全面的- 时间，终身教职员工。程序范围内使用的开顶式和微型隔离器笼不能 支持现有设施内的预期增长。此外，FSU的扩大 研究企业无疑将转化为与 免疫受损的啮齿动物和有害物质，这是由于缺乏适当的 在工程控制方面，该大学目前装备不足，无法处理。此外，最近 FSU研究副校长办公室委托进行的顾问研究 (OVPR)已确定职业健康问题，特别是人员暴露于 与开顶笼子的广泛使用有关的实验室动物过敏原。的目标是 本项目拟购置单面鼠标架6个，双面鼠标架3个，鼠标架1个 用于生物医学研究设施(BRF)隔膜的单面鼠架，结合起来， 将为啮齿动物提供1,092个鼠笼空间，并增加 间隔层增加了162%。除了空间优化外，预计还将采用所需的IVC技术 为降低职业性过敏原暴露风险，提供适当的工程控制 与免疫受损的啮齿类动物和危险物质合作，并改善 FSU动物资源的微环境条件。运营创新和 这一项目的成功为人员健康和安全以及动物福利带来了好处 提案将独特地定位FSU和LAR，以满足新兴研究的需求 企业以及目前和未来由国家卫生研究院资助的研究人员的需求。