The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep Diseases

心脏、肺、血液和睡眠疾病护理点推进中心

• 批准号: 10735580
• 负责人: BRYAN O BUCHHOLZ
• 金额: $ 181.84万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-22 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735580
• 关键词: Acceleration; Address; Adoption; Advisory Committees; Affect; American; Automobile Driving; Blood; Businesses; COVID-19 pandemic; COVID-19 testing; Cardiovascular system; Caregivers; Caring; Cessation of life; Client satisfaction; Clinic; Clinical; Clinical Research; Communication; Community Health; Data; Decision Making; Development; Device or Instrument Development; Diagnosis; Disease; Disparity; Engineering; Environment; Equitable healthcare; Family; Funding; Goals; Grant; Health; Health Personnel; Health Professional; Health Promotion; Health system; Healthcare; Heart; Heart Diseases; Hematological Disease; Home; Income; Incubated; Incubators; Intellectual Property; Knowledge; Legal patent; Life; Lung; Lung diseases; Marketing; Massachusetts; Medical; Medical Device; Mentors; Methodology; Modeling; Morbidity - disease rate; Needs Assessment; Outcome; Pathway interactions; Patients; Point of Care Technology; Policy Maker; Population Heterogeneity; Prevention; Process; Provider; Quality of Care; Research; Research Personnel; Resource-limited setting; Resources; Risk; Running; Sleep; Sleep Disorders; System; Technology; Telemedicine; Therapeutic; Time; Training; Underserved Population; United States National Institutes of Health; Universities; Vision; Work; acute care; clinical development; commercialization; community engagement; cost; design; evidence base; experience; health care availability; health care quality; health equity; health management; home test; improved; industry partner; innovation; marginalized population; medical schools; mortality; new technology; novel; patient engagement; patient oriented; personalized management; point of care; prevent; programs; research clinical testing; success; technology research and development; tool; trend; trial design; virtual healthcare

Project Summary/Abstract – Overall Core American healthcare is rapidly evolving to a state where efficiency, quality and patient satisfaction are dominant drivers. Several trends are driving fundamental changes in health care: 1) an expanding scope of virtual care and telemedicine, accelerated by the COVID-19 pandemic, has changed how patients, healthcare providers, and health systems interact; 2) a growing recognition of disparities leading to an emphasis in providing healthcare equitably for historically marginalized populations; 3) an increasing appreciation for the patient as a critical stakeholder in therapeutic decision-making, leading to an emphasis on patient-centered design; and 4) increasing access to home health to enable better diagnosis, prevention and management of health conditions, as illustrated by widespread adoption of home-testing for SARS-CoV-2. Despite this rapidly changing environment, heart (cardiovascular), lung, blood, and sleep disorders (HLBS) continue to cause significant morbidity, mortality, and cost in the US and worldwide. Combined, these diseases account for 41% of deaths in the US and lead to over $400B in direct health care expenses plus lost income to affected patients and caregivers. Thus, there are urgent unmet needs in HLBS. We will address these issues with the renewal of the Center for Advancing Point of Care Technologies (CAPCaT) in HLBS Disorders. CAPCaT is a highly successful Point-of-Care Technology Research Network (POCTRN) Center that leverages our experience running a medical product incubator, the Massachusetts Medical Device Development Center (M2D2) at the University of Massachusetts (Lowell and Worcester campuses), and our experience administering grants, running, and managing solicitations, and working 1:1 with awardees to advance their technologies toward commercialization. CAPCaT expanded upon the original vision and success of M2D2 and now has its own established track record and collaborative network to develop and optimize novel POC and home-based technologies to improve the diagnosis and management of HLBS disorders. Our objectives in achieving this goal are to continue: 1) identifying, through stakeholder engagement, the most promising POC and home-based technologies to address unmet medical needs; 2) supporting developmental plans, including pathways to adoption at the point of care or in the home; and 3) training and disseminating developing POC and home-based technologies to the different stakeholders.

项目概要/摘要-总体核心 美国的医疗保健正在迅速发展到一个效率、质量和患者满意度占主导地位的状态 司机几个趋势正在推动医疗保健的根本性变化：1）虚拟医疗的范围不断扩大 和远程医疗，由COVID-19大流行加速，已经改变了患者，医疗保健提供者， 和卫生系统相互作用; 2）日益认识到差异导致强调提供医疗保健 公平地对待历史上被边缘化的人群; 3）越来越多的人认为病人是一个关键的 利益相关者参与治疗决策，强调以患者为中心的设计;以及4） 增加获得家庭保健的机会，以便更好地诊断、预防和管理健康状况， 如SARS-CoV-2家庭测试的广泛采用所示。尽管这种快速变化 环境，心脏（心血管），肺，血液和睡眠障碍（HLBS）继续引起显着的 美国和世界范围内的发病率、死亡率和成本。这些疾病加在一起占死亡人数的41%， 美国，导致超过4000亿美元的直接医疗保健费用加上受影响患者的收入损失， 照顾者因此，在高级别业务支助方面存在着迫切的未得到满足的需求。我们将通过更新 中心推进点护理技术（CAPCaT）在HLBS疾病。CAPCaT是一个非常成功的 床旁技术研究网络（POCTRN）中心，利用我们的经验， 医疗产品孵化器，马萨诸塞州医疗器械开发中心（M2 D2）在大学 马萨诸塞州（洛厄尔和伍斯特校区），以及我们管理赠款，运行， 管理招标，并与获奖者1：1合作，推动他们的技术走向商业化。 CAPCaT扩展了M2 D2的最初愿景和成功，现在拥有自己既定的业绩记录 和协作网络，以开发和优化新的POC和基于家庭的技术， HLBS病症的诊断和管理。我们在实现这一目标方面的目标是继续：1） 通过利益相关者的参与，确定最有前途的POC和家庭技术，以解决 未满足的医疗需求; 2）支持发展计划，包括在护理点收养的途径，或 3）培训和传播发展中的POC和基于家庭的技术， 持份者

项目成果

Respiratory Adenovirus Quantification with a Droplet Digital Polymerase Chain Reaction (ddPCR) Assay.

使用微滴数字聚合酶链式反应 (ddPCR) 测定进行呼吸道腺病毒定量。

• DOI: 10.1128/spectrum.00269-23
• 发表时间: 2023-06-15
• 期刊: Microbiology spectrum
• 影响因子: 3.7

Dynamic pH and Thermal Analysis of Paper-Based Microchip Electrophoresis.

• DOI: 10.3390/mi12111433
• 发表时间: 2021-11-22
• 期刊: Micromachines
• 影响因子: 3.4
• 作者: Hasan MN;An R;Akkus A;Akkaynak D;Minerick AR;Kharangate CR;Gurkan UA
• 通讯作者: Gurkan UA

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection.

• DOI: 10.1038/s41467-021-22072-9
• 发表时间: 2021-03-26
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Shan D;Johnson JM;Fernandes SC;Suib H;Hwang S;Wuelfing D;Mendes M;Holdridge M;Burke EM;Beauregard K;Zhang Y;Cleary M;Xu S;Yao X;Patel PP;Plavina T;Wilson DH;Chang L;Kaiser KM;Nattermann J;Schmidt SV;Latz E;Hrusovsky K;Mattoon D;Ball AJ
• 通讯作者: Ball AJ

Emerging point-of-care technologies for anemia detection.

• DOI: 10.1039/d0lc01235a
• 发表时间: 2021-05-18
• 期刊: Lab on a chip
• 影响因子: 6.1
• 作者: An R;Huang Y;Man Y;Valentine RW;Kucukal E;Goreke U;Sekyonda Z;Piccone C;Owusu-Ansah A;Ahuja S;Little JA;Gurkan UA
• 通讯作者: Gurkan UA

Increased circulation of human adenovirus in 2023: an investigation of the circulating genotypes, upper respiratory viral loads, and hospital admissions in a large academic medical center.

• DOI: 10.1128/jcm.01237-23
• 发表时间: 2024-01-17
• 期刊: Journal of clinical microbiology
• 影响因子: 9.4