NIH PROMIS Statistical Coordinating Center(RMI)

NIH PROMIS 统计协调中心（RMI）

• 批准号: 7497133
• 负责人: DAVID CELLA
• 金额: $ 190.8万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-28 至 2009-04-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7497133
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DESCRIPTION (provided by applicant): This proposed Statistical Coordinating Center (SCC) for the Patient Reported Outcomes Measurement Information System (PROMIS) will provide and manage a secure, customizable data collection, management and reporting system, provide leadership and expertise in psychometric and statistical analyses; create item banks for health status domains that have relevance across a variety of chronic diseases; develop a dynamic system to administer computer adaptive tests (CAT); develop training materials for clinical researchers who will use the item banks and CAT system; and work collaboratively with the PROMIS network to develop a sustained public-private partnership. Our SCC investigators are international leaders in the development and evaluation of PRO instruments and item banks including related software for item-banking, CAT, fixed assessments, scoring and reporting in multiple languages; the design, implementation and coordination of clinical and survey research studies; and the development and application of psychometric and statistical methods for analysis of self-report data. We have already developed operational item banks for several health-related quality of life (HRQL) domains using item response theory (IRT). We have tested this system in numerous patient populations and using multiple platforms (e.g., web-based, touch screens, Integrated Voice Response (IVR)). Thus, we will provide initial PROMIS software for primary research sites (PRS) and network-based data collection from the start of the funded period. Our software includes a simulation mode that will be useful in evaluating the impact of changing IRT models, calibrations and other CAT conditions. Our proposed project team has extensive expertise in conducting pooled data analysis using IRT and other psychometric and statistical methods. We are positioned to provide leadership of PROMIS activities and advance the science behind building and applying valid and clinically useful item banks. The scientific strength of our psychometric and statistical investigators, our proven capabilities in data management and software development, and our track record of interdisciplinary and inter-institutional collaboration uniquely equip our proposed SCC to accomplish and extend our contribution beyond enabling and coordinating large-scale data collection and analysis. Using five functional teams comprised of experienced investigators and specialists, we will coordinate, adjudicate and activate input from the Steering Committee and the PRS investigators, and will include advisory input from "stakeholders" including academic clinical trialists, government, industry and patients. This collaborative effort will ensure the success of the PROMIS initiative.

描述（由申请人提供）：该拟议的患者报告结局测量信息系统（PROMIS）统计协调中心（SCC）将提供和管理一个安全、可定制的数据收集、管理和报告系统，在心理测量和统计分析方面提供领导和专业知识;为与各种慢性疾病相关的健康状况领域创建项目库;开发一个动态系统来管理计算机自适应测试（CAT）;为将使用试题库和CAT系统的临床研究人员编写培训材料;与PROMIS网络合作，发展可持续的公私伙伴关系。我们的SCC研究人员是PRO工具和项目库开发和评估的国际领导者，包括项目库，CAT，固定评估，评分和多语言报告的相关软件;临床和调查研究的设计，实施和协调;以及心理测量和统计方法的开发和应用，用于分析自我报告数据。我们已经开发了几个健康相关的生活质量（HRQL）领域使用项目反应理论（IRT）的业务项目库。我们已经在许多患者群体中测试了该系统，并使用了多个平台（例如，基于网络、触摸屏、集成语音应答（IVR））。因此，我们将从资助期开始为主要研究中心（PRS）和基于网络的数据收集提供初始PROMIS软件。我们的软件包括一个模拟模式，这将有助于评估改变IRT模型，校准和其他CAT条件的影响。我们建议的项目团队在使用IRT和其他心理测量和统计方法进行汇总数据分析方面具有广泛的专业知识。我们的定位是提供PROMIS活动的领导，并推进科学背后的建设和应用有效的和临床有用的项目库。我们的心理测量和统计调查人员的科学实力，我们在数据管理和软件开发方面的成熟能力，以及我们跨学科和机构间合作的良好记录，使我们拟议的SCC能够完成并扩展我们的贡献，超越了实现和协调大规模数据收集和分析。我们将利用由经验丰富的研究者和专家组成的五个职能团队，协调、裁定和激活指导委员会和PRS研究者的意见，并将包括来自“利益相关者”（包括学术临床试验者、政府、行业和患者）的咨询意见。这一协作努力将确保PROMIS倡议取得成功。