Ultra-High Performance Brain-dedicated PET scanner for Neurology and Neuro-oncology imaging

用于神经病学和神经肿瘤学成像的超高性能大脑专用 PET 扫描仪

• 批准号: 10737257
• 负责人: Antonio Gonzalez Martinez
• 金额: $ 54.27万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10737257
• 关键词: 3-Dimensional; Adopted; Algorithms; Alzheimer' s Disease; Anesthesia procedures; Area; Biochemical; Biochemical Pharmacology; Biological; Brain; Brain Diseases; Brain imaging; Brain region; Cell Nucleus; Characteristics; Clinical; Collaborations; Corpus striatum structure; Coupled; Dedications; Dementia; Development; Devices; Diagnosis; Diagnostic; Diameter; Disease; Dopamine; Dose; Drug Monitoring; Early Diagnosis; Early treatment; Effectiveness; Event; Evolution; Excision; Exhibits; Funding; Generations; Goals; Head; Hippocampus; Human; Image; Industrialization; Learning; Lesion; Long-Term Effects; Machine Learning; Magnetic Resonance Imaging; Marketing; Medicine; Methods; Modeling; Monitor; Monte Carlo Method; Motion; Motivation; Neurologic; Neurology; Neurotransmitters; Noise; Norepinephrine; Operative Surgical Procedures; Organ; Outcome; Parkinson Disease; Pathology; Patients; Pediatrics; Performance; Pharmacology; Physics; Positioning Attribute; Positron; Positron-Emission Tomography; Proteins; Radiation exposure; Radiation therapy; Radioactive; Research; Research Personnel; Resolution; Scanning; Shapes; Signal Transduction; Specific qualifier value; Structure; Substantia nigra structure; System; Technology; Time; Tracer; Treatment outcome; Tumor Burden; Work; X-Ray Computed Tomography; abeta deposition; attenuation; brain research; detector; entorhinal cortex; image reconstruction; improved; instrumentation; kinetic model; locus ceruleus structure; metabolic abnormality assessment; metabolic imaging; millimeter; molecular imaging; nanomolar; nervous system disorder; neural network; neuro-oncology; neurochemistry; next generation; novel; quantitative imaging; solid state; tomography; tool; treatment response; tumor; ultra high resolution

1 2 functions, 3 have 4 spatial resolution and sensitivity. Such specifications impact both neurologic and neuro-oncologic diseases. In 5 the former, they allow detecting, quantitating, and tracking small changes of PET signal in minute brain regions 6 such as brain nuclei that have been implicated in many neurologic diseases. In the latter, they improve the 7 accuracy of tumor target volume definition in radiotherapy and surgical resection, thus treatment outcome. 8 The only commercial brain-dedicated PET is the HRRT, a 2 decade old technology that has been discontinued. 9 Therefore, there is compelling need to develop the next generation brain-dedicated PET with ultra-high 10 specifications to improve diagnostics that can institute therapies earlier in the evolution of the disease. 11 This proposal brings together two highly collaborative teams from Weill Cornell Medicine (WCM) and the 12 Institute for Instrumentation in Molecular Imaging (i3M), with an industrial partner, Oncovision, to build an 13 ultra-high performance brain-dedicated PET, UHB-PET. UHB-PET will exhibit: (i) volumetric spatial 14 resolution of ~0.5mm3 across the gantry, that is >4x better than that of the best brain-dedicated PET being 15 developed; (j) effective sensitivity >26x that of the brain PET with the highest spatial resolution being developed. 16 Our intensive experimental and Monte Carlo simulation results prove that our goals are highly achievable, 17 which we will attain as follows: Specific 18 maximize 19 FOV 20 and 21 Quantitative machine 22 learning to accurately determine the 3D position of 511keV 's interaction within the semi-monolithic slab, infer the 23 attenuation-corrected PET without CT scans, and minimize image noise, thus reduce the administered dose), (d) 24 use a preconditioned fixed-point image reconstruction approach to suppress the noise in sub-millimeter size 25 pixels, (e) adopt motion tracking tool we previously developed to correct for inter- and intra- head motion during 26 dynamic PET imaging, and (f) adopt methods from our previous work to accurately image-derive the input function 27 for kinetic modeling. Specific Aim 3: Assessment of image noise, target lesion visibility and quantitative accuracy 28 attained by the scanner in a characteristic set of specific neurology and neuro-oncology human studies. 29 The ultimate goal is a fully operational ultra-high performance dedicated brain PET scanner with accurate 30 quantitative capabilities for diagnosing and monitoring treatment in brain diseases. . Positron Emission Tomography (PET) is a powerful quantitative tool for studying metabolic and biochemical pharmacology, and pathology in living brains. In the past 3 decades, a myriad of brain PET tracers, been developed.In parallel, PET underwent dramatic advancement in technology that enabled much higher Aim 1 : In 2.5 years we will build UHB-PET with trapezoidal-shape (to sensitivity) semi-monolithic LYSO slabs coupled to high-performance SiPM readout, 26.7cm axial and ~28cm diameter, high 200psec detector timing resolution, isotropic spatial resolution <0.8mm FWHM 0.72mm Depth-of-interaction (DOI) resolution. Specific AIM2 : In parallel with AIM1, we will develop a Image Reconstruction tool. We will (a) incorporate accurate physics modeling, (b) use

1 2个功能， 3具有 4空间分辨率和灵敏度。这些规范影响神经系统疾病和神经肿瘤疾病。在 5前者，它们允许检测，定量和跟踪微小脑区域中PET信号的微小变化 6，例如与许多神经系统疾病有关的脑核。在后一种情况下，它们改善了 7放疗和手术切除中肿瘤靶体积定义的准确性，从而获得治疗结果。 8唯一的商业化脑专用PET是HRRT，这是一项已有20年历史的技术，现已停止使用。 因此，迫切需要开发具有超高分辨率的下一代脑专用PET。 10个规范，以改善诊断，可以在疾病演变的早期制定治疗方法。 11这项提案汇集了来自威尔康奈尔医学（WCM）和 12分子成像仪器研究所（i3 M）与工业合作伙伴Oncovision共同建立一个 13超高性能脑专用PET，UHB-PET。UHB-PET将显示：（i）体积空间 整个机架的分辨率约为0.5mm3，比最好的脑部专用PET高出> 4倍， （j）有效灵敏度> 26倍于正在开发的具有最高空间分辨率的脑PET。 16我们密集的实验和蒙特卡罗模拟结果证明，我们的目标是高度可实现的， 17我们将实现如下：具体 18最大化 19视野 20和 21定量机 22学习准确地确定511 keV电子束在半单片板内的相互作用的3D位置，推断 23无CT扫描的衰减校正PET，并最大限度地减少图像噪声，从而减少给药剂量），（d） 24使用预处理定点图像重建方法来抑制亚毫米尺寸的噪声 25像素，（e）采用我们以前开发的运动跟踪工具，以纠正头部间和头部内运动， 26动态PET成像，以及（f）采用我们之前工作中的方法来准确地图像推导输入函数 27个用于动力学建模。具体目标3：评估图像噪声、靶病变可见性和定量准确性 28通过扫描仪在一组特定的神经学和神经肿瘤学人类研究中获得。 29最终目标是一个完全可操作的超高性能专用脑PET扫描仪， 30定量诊断和监测治疗脑部疾病的能力。. 正电子发射断层扫描（PET）是研究代谢和生物化学的有力定量工具 药理学和病理学在活体大脑中的应用。在过去的30年里，无数的大脑PET示踪剂， 与此同时，PET经历了技术上的巨大进步， 目标1：在2.5年内，我们将建造梯形UHB-PET（以 灵敏度）半单片LYSO板耦合到高性能SiPM读出，26.7厘米轴向 直径约28 cm，探测器时间分辨率高达200 psec，各向同性空间分辨率<0.8mm FWHM 0.72mm相互作用深度（DOI）分辨率。具体AIM 2：与AIM 1并行，我们将开发一个 图像重建工具。我们将（a）结合精确的物理建模，（B）使用