Music mechanisms and technologies network: Integrative models to address pain through music

项目摘要/摘要本U24申请是根据RFA-AT-23-009编写的，以建立 一个高度优先的研究网络，探索基于音乐的潜在机制和新技术 干预(MBI)和疼痛研究。疼痛是一种多维度的体验，它会导致重大的个人 以及社会成本。药物治疗、手术治疗和麻醉疼痛程序提供了一些缓解； 然而，它们各自都有很大的风险，并且没有解决心理社会、行为和/或 影响慢性疼痛状况的神经生理学因素。因此，成年人正在转向非 控制疼痛的药理学、低风险方法--包括综合疗法，如MBIS。Meta- 分析结果表明，MBIS的有效性是高度可变的，具有暂定的临床重要性。二 问题与MBI科学的现状特别相关：1)尚不清楚研究人员如何决定 在mbi中包括的组成部分，以解决疼痛的生物、心理和社会性质，以及2)对主观的依赖 缺乏心理测量学严谨性和对外部心理社会因素过于敏感的措施。MBI 研究没有遵循传统的发展道路，而是专注于有效性试验，而忽略了 基础开发和优化研究。将心理社会、行为和/或 神经生理学，同时开发和测试技术来补充患者- 报告的结果，将为严格的前瞻性试验提供基础。这个U24网络将组装成 跨学科的科学家小组，大大促进了我们对潜在机制的理解 音乐缓解疼痛的能力，并开发新技术来补充患者-报告 结果。该网络将由来自包括音乐在内的广泛领域的科学家和临床医生组成 治疗、心理学、工程学、神经科学、社会工作和医学。核心调查小组将 通过专业和科学组织以及学术组织征集更多科学家的参与 财团。该网络将侧重于以下主要目标：目标1：解决我们的主要差距 了解MBIS在慢性疼痛中的生物心理社会机制，包括生物标记物。目标2： 探索新的技术和方法，以增强客观、非侵入性的疼痛测量 音乐体验的背景。目标3实施试点方案，专门为试点干预研究提供资金 专注于推进基于音乐的疼痛研究的机制和技术。该网络将 建立跨学科团队并引入新的研究人员进入该领域，以弥合基础、应用、 和临床研究，传播一个概念性框架，以了解机制和 在MBIS中测量疼痛，并建立用于赠款申请的初步数据集。在这些 通过这种方式，该网络将极大地加速专注于MBI研究的优化项目。

PROJECT SUMMARY/ABSTRACT This U24 application is written in response to RFA-AT-23-009 to establish a high-priority research network exploring potential mechanisms and novel technologies in music-based intervention (MBI) and pain research. Pain is a multidimensional experience that leads to significant personal and societal costs. Pharmacological, surgical treatments, and anesthesia pain procedures provide some relief; however, they each have significant risks and do not address the psychosocial, behavioral, and/or neurophysiological factors influencing chronic pain conditions. As such, adults are turning to non- pharmacological, lower risk methods to manage pain –include integrative therapies such as MBIs. Meta- analytic results suggest the effectiveness of MBIs is highly variable, with tentative clinical importance. Two issues are especially relevant to the current state of MBI science: 1) it is unclear how researchers decide which components to include in MBIs to address the biopsychosocial nature of pain, and 2) the reliance on subjective measures that lack psychometric rigor and that are overly sensitive to extraneous psychosocial factors. MBI research has not followed the traditional development pathway, but focused on effectiveness trials, omitting essential development and optimization studies. A framework linking psychosocial, behavioral, and/or neurophysiological, in parallel with the development and testing of technologies to complementing patient- reported outcomes, will provide the foundation for rigorous, prospective trials. This U24 network will assemble cross disciplinary group of scientists to significantly advance our understanding of the mechanisms underlying music’s capacity to alleviate pain, and to develop novel technologies to complement patient-reported outcomes. The network will consist of scientists and clinicians from a broad range of fields including music therapy, psychology, engineering, neuroscience, social work, and medicine. The core investigative team will solicit participation of additional scientists through professional and scientific organizations and academic consortiums. The network will focus on the following major aims: Aim 1: To address major gaps in our understanding of the biopsychosocial mechanisms, including biomarkers, of MBIs in chronic pain. Aim 2: Explore novel technologies and methods to enhance the objective, unobtrusive measurement of pain within the context of music experiences. Aim 3 Implement a pilot program to fund pilot intervention studies specifically focusing on the mechanisms and technologies to advance music-based pain research. The network will establish cross disciplinary teams and bring new investigators into this field to bridge gaps in basic, applied, and clinical research, disseminate a conceptual framework for understanding the mechanisms and measurement of pain within MBIs, and establish preliminary datasets for use in grant applications. In these ways, the network will dramatically accelerate programs focused on the optimization of MBI research.