Music mechanisms and technologies network: Integrative models to address pain through music

音乐机制和技术网络：通过音乐解决疼痛的综合模型

• 批准号: 10765327
• 负责人: Debra S Burns
• 金额: $ 50.77万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-21 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10765327
• 关键词: Absenteeism at work; Acceleration; Acute Pain; Address; Adult; Adverse effects; Adverse event; American; Analgesics; Anesthesia procedures; Applications Grants; Applied Research; Basic Science; Behavioral; Biological Assay; Biological Markers; Clinical; Clinical Research; Clinical Trials; Complement; Complex; Data; Data Set; Development; Dimensions; Educational workshop; Effectiveness; Electrophysiology (science); Employment; Engineering; Financial Hardship; Foundations; Funding; Future; Health; Health Care Costs; Homelessness; Image; Integrative Therapy; Intervention; Intervention Studies; Link; Measurement; Measures; Mediating; Medicine; Methodology; Methods; Mission; Modeling; Music; Music Therapy; Neurosciences; Operative Surgical Procedures; Opioid; Outcome; Pain; Pain Measurement; Pain Nature; Pain Research; Pain management; Paper; Pathway interactions; Patient Outcomes Assessments; Patient Self-Report; Patients; Performance; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Pilot Projects; Policies; Procedures; Process; Productivity; Professional Organizations; Psychologist; Psychology; Psychometrics; Psychosocial Factor; Public Health; Recommendation; Reporting; Research; Research Personnel; Research Priority; Risk; Role; Science; Scientist; Secure; Social Work; Social Workers; Structure; Techniques; Technology; Testing; Therapeutic Effect; Translating; Unemployment; United States National Institutes of Health; Work; Writing; addiction; biopsychosocial; chronic pain; chronic painful condition; clinical practice; effectiveness trial; experience; improved; interest; meetings; neurophysiology; new technology; non-opioid analgesic; novel; pharmacologic; preference; programs; prospective; psychosocial; response; scientific organization; side effect; social; societal costs; therapy development; webinar; working group

PROJECT SUMMARY/ABSTRACT This U24 application is written in response to RFA-AT-23-009 to establish a high-priority research network exploring potential mechanisms and novel technologies in music-based intervention (MBI) and pain research. Pain is a multidimensional experience that leads to significant personal and societal costs. Pharmacological, surgical treatments, and anesthesia pain procedures provide some relief; however, they each have significant risks and do not address the psychosocial, behavioral, and/or neurophysiological factors influencing chronic pain conditions. As such, adults are turning to non- pharmacological, lower risk methods to manage pain –include integrative therapies such as MBIs. Meta- analytic results suggest the effectiveness of MBIs is highly variable, with tentative clinical importance. Two issues are especially relevant to the current state of MBI science: 1) it is unclear how researchers decide which components to include in MBIs to address the biopsychosocial nature of pain, and 2) the reliance on subjective measures that lack psychometric rigor and that are overly sensitive to extraneous psychosocial factors. MBI research has not followed the traditional development pathway, but focused on effectiveness trials, omitting essential development and optimization studies. A framework linking psychosocial, behavioral, and/or neurophysiological, in parallel with the development and testing of technologies to complementing patient- reported outcomes, will provide the foundation for rigorous, prospective trials. This U24 network will assemble cross disciplinary group of scientists to significantly advance our understanding of the mechanisms underlying music’s capacity to alleviate pain, and to develop novel technologies to complement patient-reported outcomes. The network will consist of scientists and clinicians from a broad range of fields including music therapy, psychology, engineering, neuroscience, social work, and medicine. The core investigative team will solicit participation of additional scientists through professional and scientific organizations and academic consortiums. The network will focus on the following major aims: Aim 1: To address major gaps in our understanding of the biopsychosocial mechanisms, including biomarkers, of MBIs in chronic pain. Aim 2: Explore novel technologies and methods to enhance the objective, unobtrusive measurement of pain within the context of music experiences. Aim 3 Implement a pilot program to fund pilot intervention studies specifically focusing on the mechanisms and technologies to advance music-based pain research. The network will establish cross disciplinary teams and bring new investigators into this field to bridge gaps in basic, applied, and clinical research, disseminate a conceptual framework for understanding the mechanisms and measurement of pain within MBIs, and establish preliminary datasets for use in grant applications. In these ways, the network will dramatically accelerate programs focused on the optimization of MBI research.

项目总结/摘要本U24申请是为了响应RFA-AT-23-009而编写的，以确定 一个高优先级的研究网络，探索基于音乐的潜在机制和新技术， 干预（MBI）和疼痛研究。疼痛是一种多维度的体验， 和社会成本。药物、手术治疗和麻醉疼痛程序提供了一些缓解; 然而，它们都有很大的风险，并且没有解决心理社会，行为和/或 影响慢性疼痛状况的神经生理学因素。因此，成年人转向非- 药理学，低风险的方法来管理疼痛-包括综合治疗，如MBIs。Meta- 分析结果表明，MBIs的有效性是高度可变的，具有初步的临床意义。两 问题是特别相关的MBI科学的现状：1）目前还不清楚研究人员如何决定， 成分包括在MBIs，以解决疼痛的生物心理社会性质，和2）对主观的依赖 缺乏心理测量的严谨性，对外部心理社会因素过于敏感。MBI 研究没有遵循传统的发展途径，而是集中在有效性试验，忽略了 必要的开发和优化研究。一个框架，将社会心理、行为和/或 神经生理学，同时开发和测试技术，以补充患者- 报告的结果，将为严格的前瞻性试验提供基础。这个U24网络将组装 跨学科的科学家小组，以显着推进我们对潜在机制的理解 音乐的能力，以减轻疼痛，并开发新的技术，以补充病人报告 结果。该网络将由包括音乐在内的广泛领域的科学家和临床医生组成 治疗学、心理学、工程学、神经科学、社会工作和医学。核心调查小组将 通过专业和科学组织以及学术界， 财团该网络将侧重于以下主要目标：目标1： 了解慢性疼痛中MBIs的生物心理社会机制，包括生物标志物。目标二： 探索新的技术和方法，以加强客观，不引人注目的测量疼痛内 音乐体验的背景。目标3：实施试点计划，专门为试点干预研究提供资金 专注于机制和技术，以推进基于音乐的疼痛研究。该网络将 建立跨学科小组，并将新的调查人员带入这一领域，以弥合基础、应用 和临床研究，传播理解机制的概念框架， 测量MBIs内的疼痛，并建立初步的数据集用于资助申请。在这些 通过各种方式，该网络将大大加快专注于MBI研究优化的项目。