Colorado Clinical and Translational Sciences Institute (CCTSI)

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PROJECT SUMMARY/ABSTRACT Funded by NIH in 2008, 2013 and 2018, the Colorado Clinical and Translational Sciences Institute (CCTSI) at the University of Colorado Denver (CU Denver) has transformed the clinical and translational research and training enterprise in the Colorado region with the vision of accelerating the translation of discoveries into improved, equitable patient care and public health for all. The CCTSI, headquartered at the CU Anschutz Medical Campus, is a partnership of CU Denver, CU Boulder, Colorado State University (CSU), 5 hospital systems and 20 community organizations, which has advanced translational science by educating a diverse workforce, creating a collaborative environment that supports local and multi-site research, engaging communities through its unique community engagement program, creating methodologies that support research in special populations, and greatly enhancing our informatics and data science capabilities. The CCTSI infrastructure played a critical role in the Colorado response to the COVID pandemic and led to new innovations in research processes and implementation, while recognizing the health inequities and disparities exposed by the pandemic in rural, minority and underserved populations in Colorado. Despite the successes, there remain many challenges to overcoming inefficiencies and roadblocks in clinical translational science (CTS) processes locally and nationally and in reducing health disparities and inequities. This application maps our collaborative path forward to meet these challenges. In the next grant cycle, we will enhance our efforts to improve efficiency and coordination with Partners and across the CTSA Consortium, reinforce our extensive community partnerships, develop innovative informatics and technology solutions to advance CTS, and develop a diverse highly-skilled translational workforce for the future. This UM1 will be tightly coordinated with our other 6 CTSA grant applications, to accomplish the following 6 Overall Strategic Goals: Goal 1: Advance CTS by developing, demonstrating, and disseminating innovative programs to improve the efficiency and impact of translation across the entire T0.5 to T4 spectrum. Goal 2: Promote collaboration, team and data science, and partnerships to accelerate CTS locally, regionally and nationally. Goal 3: Partner locally, regionally and nationally with institutions, stakeholders and communities to develop innovative research programs that will address health inequities and disparities. Goal 4: Further develop operational efficiencies to enhance the quality, safety, efficiency, effectiveness and informativeness of clinical research. Goal 5: Promote a nimble research environment that can rapidly respond to urgent public health needs. Goal 6: Develop and disseminate CTS training programs that educate and sustain a resilient, diverse team of clinical research professionals and investigators. Special efforts will be made to enhance diversity in our workforce. Progress will be monitored and improved by our Evaluation Core and CQI program and we will make mid-course corrections as needed to achieve these goals and ultimately improve the health of our state and the nation.