Colorado Clinical and Translational Sciences Institute (CCTSI)

项目摘要/摘要 由美国国立卫生研究院于2008、2013和2018年资助的科罗拉多州临床和翻译科学研究所(CCTSI)位于 科罗拉多大学丹佛分校(CU Denver)已经改变了临床和翻译研究和 科罗拉多地区的培训企业，希望加快将发现转化为 为所有人改善、公平的病人护理和公共卫生。CCTSI，总部设在CU Anschutz Medical 校园，是CU Denver、CU Boulder、科罗拉多州立大学(CSU)、5个医院系统和 20个社区组织，通过教育不同的劳动力来促进翻译科学的发展， 创建支持本地和多站点研究的协作环境，通过 其独特的社区参与计划，创建了支持特殊领域研究的方法 并极大地增强了我们的信息学和数据科学能力。CCTSI基础设施 在科罗拉多州应对COVID大流行方面发挥了关键作用，并在研究方面带来了新的创新 进程和执行，同时认识到这一大流行病暴露出的卫生不平等和差距 在科罗拉多州的农村、少数民族和服务不足的人口中。尽管取得了成功，但仍有许多 克服临床转化科学(CTS)过程中的低效和障碍的挑战 在地方和国家以及在减少健康差距和不平等方面取得进展。此应用程序将我们的 应对这些挑战的协作之路。在下一个拨款周期，我们会加强以下工作： 提高与合作伙伴和整个CTSA联盟的效率和协调，加强我们广泛的 社区伙伴关系，开发创新的信息学和技术解决方案以推进CTS，并开发 一支面向未来的多元化的高技能翻译队伍。这个UM1将与我们的另一个紧密协调 6个CTSA赠款申请，以实现以下6个总体战略目标：目标1：推动CTS 开发、示范和传播创新计划，以提高效率和影响 从T0.5到T4的整个频谱的翻译。目标2：促进协作、团队和数据科学，以及 建立伙伴关系，以加快地方、区域和国家的技术合作。目标3：地方、区域和国家合作伙伴 与机构、利益攸关方和社区一起制定创新的研究计划，以解决卫生问题 不平等和不平等。目标4：进一步提高运营效率，以提高质量、安全、 临床研究的效率、有效性和信息量。目标5：促进灵活的研究 能够迅速应对紧迫的公共卫生需求的环境。目标6：开发和传播CTS 培训计划，教育和维持一支有弹性的、多样化的临床研究专业人员团队和 调查人员。我们会作出特别努力，加强工作人口的多元化。将监测进展情况，并 通过我们的评估核心和CQI计划进行改进，我们将根据需要进行中期更正 实现这些目标，并最终改善我们州和民族的健康。

PROJECT SUMMARY/ABSTRACT Funded by NIH in 2008, 2013 and 2018, the Colorado Clinical and Translational Sciences Institute (CCTSI) at the University of Colorado Denver (CU Denver) has transformed the clinical and translational research and training enterprise in the Colorado region with the vision of accelerating the translation of discoveries into improved, equitable patient care and public health for all. The CCTSI, headquartered at the CU Anschutz Medical Campus, is a partnership of CU Denver, CU Boulder, Colorado State University (CSU), 5 hospital systems and 20 community organizations, which has advanced translational science by educating a diverse workforce, creating a collaborative environment that supports local and multi-site research, engaging communities through its unique community engagement program, creating methodologies that support research in special populations, and greatly enhancing our informatics and data science capabilities. The CCTSI infrastructure played a critical role in the Colorado response to the COVID pandemic and led to new innovations in research processes and implementation, while recognizing the health inequities and disparities exposed by the pandemic in rural, minority and underserved populations in Colorado. Despite the successes, there remain many challenges to overcoming inefficiencies and roadblocks in clinical translational science (CTS) processes locally and nationally and in reducing health disparities and inequities. This application maps our collaborative path forward to meet these challenges. In the next grant cycle, we will enhance our efforts to improve efficiency and coordination with Partners and across the CTSA Consortium, reinforce our extensive community partnerships, develop innovative informatics and technology solutions to advance CTS, and develop a diverse highly-skilled translational workforce for the future. This UM1 will be tightly coordinated with our other 6 CTSA grant applications, to accomplish the following 6 Overall Strategic Goals: Goal 1: Advance CTS by developing, demonstrating, and disseminating innovative programs to improve the efficiency and impact of translation across the entire T0.5 to T4 spectrum. Goal 2: Promote collaboration, team and data science, and partnerships to accelerate CTS locally, regionally and nationally. Goal 3: Partner locally, regionally and nationally with institutions, stakeholders and communities to develop innovative research programs that will address health inequities and disparities. Goal 4: Further develop operational efficiencies to enhance the quality, safety, efficiency, effectiveness and informativeness of clinical research. Goal 5: Promote a nimble research environment that can rapidly respond to urgent public health needs. Goal 6: Develop and disseminate CTS training programs that educate and sustain a resilient, diverse team of clinical research professionals and investigators. Special efforts will be made to enhance diversity in our workforce. Progress will be monitored and improved by our Evaluation Core and CQI program and we will make mid-course corrections as needed to achieve these goals and ultimately improve the health of our state and the nation.