New York State BD-STEPS: Component A and B

纽约州 BD-STEPS：A 部分和 B 部分

• 批准号: 10764615
• 负责人: Marilyn L. Browne
• 金额: $ 90万
• 依托单位: NYSDOH/HEALTH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764615
• 关键词: New; York; State; BD; STEPS

Project Summary The New York State Center for Birth Defects Research and Prevention (NYSCBDRP) proposes to continue its strong record of conducting epidemiologic research to identify the causes of birth defects through its participation in the Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS). The NYSCBDRP has been a major contributor to CDC’s collaborative National Birth Defects Prevention Study (NBDPS) and BD- STEPS since 1996. The NYSCBDRP is situated in the New York State Department of Health (NYSDOH) Birth Defects Registry and enjoys a strong collaborative relationship with the University at Albany School of Public Health. The Specific Aims of this project are to: (1) identify birth defect cases and controls from two geographically and sociodemographically diverse catchment areas in New York State; (2) conduct epidemiologic investigations on non-genetic risk factors for specific birth defects, including medications, chronic and infectious disease, occupational factors, social determinants of health, and health equity, resulting in at least 7 publications and 7 presentations over 3.5 years; (3) contribute residual newborn bloodspots and investigate genetic factors for birth defects; (4) link individuals to the NYS National Electronic Disease Surveillance System to ascertain and characterize the impact of infections before and during pregnancy on birth defects; (5) evaluate and develop existing and novel modes of information collection for BD-STEPS; and (6) mentor and train future birth defects researchers by offering internships and thesis/dissertation data for graduate students at the University at Albany School of Public Health and training opportunities for junior NYSCBDRP analysts. From its position within the NYSDOH, the NYSCBDRP will leverage considerable resources through donated staff time, privileged access to individual medical records, the Birth Defects Registry, infectious disease surveillance systems, and affiliation with the world-renowned Wadsworth Center laboratory for genetic studies. The NYSCBDRP has demonstrated success implementing the NBDPS and BD- STEPS studies and conducting birth defects research, with the highest BD-STEPS participation rate and more than 50 peer-reviewed publications of NBDPS/BD-STEPS analyses led by an NYS author. The NYSCBDRP is well-positioned to continue successfully implementing BD-STEPS, helping to increase knowledge of risk factors for birth defects and inform prevention strategies.

项目摘要 纽约州出生缺陷研究和预防中心（NYSCBDRP）建议继续其 进行流行病学研究的良好记录，以确定出生缺陷的原因， 参与出生缺陷研究以评估妊娠期缺陷（BD-STEPS）。NYSCBDRP已经 一直是CDC的合作国家出生缺陷预防研究（NBDPS）和BD的主要贡献者- 自1996年以来，NYSCBDRP位于纽约州卫生部（NYSDOH） 缺陷登记处，并享有与大学在奥尔巴尼公共学院强有力的合作关系 健康该项目的具体目标是：（1）从两个地区识别出生缺陷病例和对照。 纽约州地理和社会人口多样的集水区;（2）进行 对特定出生缺陷的非遗传风险因素进行流行病学调查，包括药物， 慢性病和传染病、职业因素、健康的社会决定因素和健康公平， 在3.5年内至少发表了7篇出版物和7次报告;（3）提供残留的新生儿血斑， 调查出生缺陷的遗传因素;（4）将个人与纽约州国家电子疾病联系起来 监测系统，以确定和描述怀孕前和怀孕期间感染对妇女的影响 （5）评估和开发BD-STEPS现有的和新的信息收集模式;以及 (6)通过提供实习和论文/论文数据，指导和培训未来的出生缺陷研究人员， 研究生在大学公共卫生学院的奥尔巴尼和初级培训机会 NYSCBDRP分析师。从其在NYSDOH的地位，NYSCBDRP将利用相当大的 资源通过捐赠的工作人员的时间，特权访问个人的医疗记录，出生缺陷 登记、传染病监测系统以及与世界著名的沃兹沃斯中心的联系 基因研究实验室。NYSCBDRP已经成功实施了NBDPS和BD- STEPS研究和开展出生缺陷研究，BD-STEPS参与率最高， 超过50篇由纽约州作者领导的NBDPS/BD-STEPS分析的同行评审出版物。NYSCBDRP是 有能力继续成功实施BD-STEPS，帮助增加风险知识 出生缺陷的影响因素，并为预防战略提供信息。