New York State BD-STEPS: Component A and B

纽约州 BD-STEPS：A 部分和 B 部分

• 批准号: 10764615
• 负责人: Marilyn L. Browne
• 金额: $ 90万
• 依托单位: NYSDOH/HEALTH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764615
• 关键词: New; York; State; BD; STEPS

Project Summary The New York State Center for Birth Defects Research and Prevention (NYSCBDRP) proposes to continue its strong record of conducting epidemiologic research to identify the causes of birth defects through its participation in the Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS). The NYSCBDRP has been a major contributor to CDC’s collaborative National Birth Defects Prevention Study (NBDPS) and BD- STEPS since 1996. The NYSCBDRP is situated in the New York State Department of Health (NYSDOH) Birth Defects Registry and enjoys a strong collaborative relationship with the University at Albany School of Public Health. The Specific Aims of this project are to: (1) identify birth defect cases and controls from two geographically and sociodemographically diverse catchment areas in New York State; (2) conduct epidemiologic investigations on non-genetic risk factors for specific birth defects, including medications, chronic and infectious disease, occupational factors, social determinants of health, and health equity, resulting in at least 7 publications and 7 presentations over 3.5 years; (3) contribute residual newborn bloodspots and investigate genetic factors for birth defects; (4) link individuals to the NYS National Electronic Disease Surveillance System to ascertain and characterize the impact of infections before and during pregnancy on birth defects; (5) evaluate and develop existing and novel modes of information collection for BD-STEPS; and (6) mentor and train future birth defects researchers by offering internships and thesis/dissertation data for graduate students at the University at Albany School of Public Health and training opportunities for junior NYSCBDRP analysts. From its position within the NYSDOH, the NYSCBDRP will leverage considerable resources through donated staff time, privileged access to individual medical records, the Birth Defects Registry, infectious disease surveillance systems, and affiliation with the world-renowned Wadsworth Center laboratory for genetic studies. The NYSCBDRP has demonstrated success implementing the NBDPS and BD- STEPS studies and conducting birth defects research, with the highest BD-STEPS participation rate and more than 50 peer-reviewed publications of NBDPS/BD-STEPS analyses led by an NYS author. The NYSCBDRP is well-positioned to continue successfully implementing BD-STEPS, helping to increase knowledge of risk factors for birth defects and inform prevention strategies.

项目摘要 纽约州先生缺陷研究与预防中心（NYSCBDRP）的提议继续其 进行流行病学研究以确定出生缺陷的原因的有力记录 参加先天缺陷研究以评估妊娠暴露（BD步骤）。 NYSCBDRP具有 我们是疾病预防控制中心（CDC）合作的民族出生缺陷预防研究（NBDPS）和BD-的主要贡献者 自1996年以来的步骤。NYSCBDRP位于纽约州卫生部（NYSDOH）出生 缺陷注册表并与奥尔巴尼公立学院的大学享有牢固的合作关系 健康。该项目的具体目的是：（1）确定来自两个的先天缺陷案例和控制 纽约州的地理和社会学多样化的集水区； （2）行为 关于特定先天缺陷的非遗传危险因素的流行病学研究，包括药物， 慢性和传染病，职业因素，卫生社会决定者和健康公平，导致 在至少7个出版物和7个演讲中，超过3。5年； （3）贡献残留的新生儿斑点和 研究先天缺陷的遗传因素； （4）将个人与纽约州国家电子疾病联系起来 监视系统以确定和表征怀孕之前和期间感染的影响 出生缺陷； （5）评估和开发为BD步骤的现有和新颖的信息收集方式；和 （6）导师和培训未来的出生缺陷研究人员通过提供实习和论文/论文数据 奥尔巴尼大学公共卫生学院大学的研究生和初级培训机会 NYSCBDRP分析师。 NYSCBDRP从NYSDOH内的位置，将利用大量 通过捐赠员工时间，特权访问各个病历的资源，出生缺陷 登记处，传染病监视系统，并与世界知名的沃兹沃思中心有关联 遗传研究实验室。 NYSCBDRP证明了实施NBDP和BD-的成功 步骤研究和进行先天缺陷研究，BD步骤参与率最高 由NYS作者领导的NBDPS/BD-Steps分析的50个同行评审出版物。 NYSCBDRP是 位置良好，可以继续成功实施BD步骤，有助于提高风险知识 出生缺陷的因素并为预防策略提供信息。