New York State Component A: BD-STEPS II Core

纽约州 A 部分：BD-STEPS II 核心

• 批准号: 10264766
• 负责人: Marilyn L. Browne
• 金额: $ 90万
• 依托单位: CENTER OF ENVIRONMENTAL HEALTH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10264766
• 关键词: New; York; State; Component; BD

Project Summary The New York Center for Birth Defects Research and Prevention (NYCBDRP) proposes to continue its strong record of conducting epidemiologic research to identify the causes of birth defects through its participation in the Birth Defects Study to Evaluate Pregnancy exposureS II (BD-STEPS II). BD-STEPS II seeks to build on existing efforts to identify maternal exposures in early pregnancy that may increase the risk for having a pregnancy affected by certain major, structural birth defects. The NYCBDRP is well positioned to successfully implement BD-STEPS II. The NYCBDRP has been a major contributor to CDC's collaborative National Birth Defects Prevention Study (NBDPS) and the Birth Defects Study To Evaluate Pregnancy exposureS I (BD-STEPS I) since 1996. NYCBDRP researchers have already used NBDPS/BD-STEPS I data extensively to study the three main focus areas of BD-STEPS II: acute conditions such as infections; chronic conditions such as autoimmune disease, hypertension, and asthma; and medications to treat these conditions. The NYCBDRP has an experienced team in place to successfully implement all aspects of the proposed study: case and control ascertainment, clinical and contact information abstraction and review, subject recruitment, newborn bloodspot collection, linkages to state infectious disease surveillance systems, linkages to the New York State All Payer Database (APD) to validate self-reported medication use, and innovative epidemiologic investigations. The NYCBDRP research agenda will focus on expanding medication analyses using new BD-STEPS questions, developing analytic methods to identify risk factors for rare defects and patterns of co-occurring birth defects, and exploring the joint effects of chronic conditions and treatments on birth defect risk. The proposed pilot validation study will build on NYCBDRP subject matter expertise by focusing on antihypertensive medication use. Through a close relationship with the University at Albany School of Public Health, the NYCBDRP will continue to attract and mentor graduate-level students to conduct master's and dissertation projects using NBDPS/BD-STEPS data. From its position within the New York State Department of Health (NYSDOH), the NYCBDRP will leverage considerable NYSDOH resources through donated staff time, privileged access to individual medical records, the Congenital Malformations Registry, infectious disease surveillance systems, and the APD, and affiliation with the world-renowned Wadsworth Center laboratory for genetic studies.

项目摘要 纽约先天缺陷研究与预防中心（NYCBDRP）提议 继续其进行流行病学研究以识别出生原因的强大记录 通过参与先天缺陷研究来评估妊娠暴露II的缺陷II （BD-Steps II）。 BD-Steps II旨在基于现有的努力来确定母亲的暴露 早期怀孕可能会增加患有某些专业影响的怀孕风险， 结构性先天缺陷。 NYCBDRP可以成功实施BD步骤 ii。 NYCBDRP是CDC合作的国家先天缺陷的主要贡献者 预防研究（NBDP）和出生缺陷研究以评估妊娠暴露I （BD步骤i）自1996年以来。NYCBDRP研究人员已经使用了NBDPS/BD-Steps I数据 广泛研究BD步骤II的三个主要重点区域II：急性条件，例如 感染；慢性疾病，例如自身免疫性疾病，高血压和哮喘；和 治疗这些疾病的药物。 NYCBDRP拥有一支经验丰富的团队 成功地实施拟议研究的所有方面：病例和控制确定， 临床和联系信息抽象和审查，受试者招聘，新生儿 血迹收集，与州传染病监测系统的联系，与 纽约州所有付款人数据库（APD）以验证自我报告的用药使用，并且 创新的流行病学研究。 NYCBDRP研究议程将重点放在 使用新的BD步骤问题扩展药物分析，开发分析方法 确定罕见缺陷和同时出现先天缺陷的模式的风险因素，并探索 慢性病和治疗对先天缺陷风险的关节影响。拟议的飞行员 验证研究将基于NYCBDRP主题专业知识，通过关注 使用降压药。通过与奥尔巴尼大学的密切关系 NYCBDRP公共卫生学院将继续吸引和指导研究生级 学生使用NBDPS/BD-Steps数据进行硕士和论文项目。从它的 在纽约州卫生部（NYSDOH）内的位置，NYCBDRP将 通过捐赠的员工时间，特权访问权限来利用大量的Nysdoh资源 个体病历，先天性畸形注册表，传染病 监视系统和APD以及与世界知名的沃兹沃思中心的隶属关系 遗传研究实验室。