New York State Component A: BD-STEPS II Core
纽约州 A 部分:BD-STEPS II 核心
基本信息
- 批准号:10264766
- 负责人:
- 金额:$ 90万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Project Summary
The New York Center for Birth Defects Research and Prevention (NYCBDRP) proposes to
continue its strong record of conducting epidemiologic research to identify the causes of birth
defects through its participation in the Birth Defects Study to Evaluate Pregnancy exposureS II
(BD-STEPS II). BD-STEPS II seeks to build on existing efforts to identify maternal exposures in
early pregnancy that may increase the risk for having a pregnancy affected by certain major,
structural birth defects. The NYCBDRP is well positioned to successfully implement BD-STEPS
II. The NYCBDRP has been a major contributor to CDC's collaborative National Birth Defects
Prevention Study (NBDPS) and the Birth Defects Study To Evaluate Pregnancy exposureS I
(BD-STEPS I) since 1996. NYCBDRP researchers have already used NBDPS/BD-STEPS I data
extensively to study the three main focus areas of BD-STEPS II: acute conditions such as
infections; chronic conditions such as autoimmune disease, hypertension, and asthma; and
medications to treat these conditions. The NYCBDRP has an experienced team in place to
successfully implement all aspects of the proposed study: case and control ascertainment,
clinical and contact information abstraction and review, subject recruitment, newborn
bloodspot collection, linkages to state infectious disease surveillance systems, linkages to the
New York State All Payer Database (APD) to validate self-reported medication use, and
innovative epidemiologic investigations. The NYCBDRP research agenda will focus on
expanding medication analyses using new BD-STEPS questions, developing analytic methods to
identify risk factors for rare defects and patterns of co-occurring birth defects, and exploring the
joint effects of chronic conditions and treatments on birth defect risk. The proposed pilot
validation study will build on NYCBDRP subject matter expertise by focusing on
antihypertensive medication use. Through a close relationship with the University at Albany
School of Public Health, the NYCBDRP will continue to attract and mentor graduate-level
students to conduct master's and dissertation projects using NBDPS/BD-STEPS data. From its
position within the New York State Department of Health (NYSDOH), the NYCBDRP will
leverage considerable NYSDOH resources through donated staff time, privileged access to
individual medical records, the Congenital Malformations Registry, infectious disease
surveillance systems, and the APD, and affiliation with the world-renowned Wadsworth Center
laboratory for genetic studies.
项目摘要
纽约出生缺陷研究和预防中心(NYCBDRP)建议
继续其进行流行病学研究以确定出生原因的良好记录
通过参与出生缺陷研究评估妊娠暴露的缺陷2
(BD--步骤II)。BD-STEPS II寻求在现有努力的基础上确定产妇在#年的接触情况
早孕可能会增加怀孕的风险,
结构性先天缺陷。NYCBDRP处于有利地位,可以成功实施BD-STEP
2.NYCBDRP是美国疾病控制与预防中心合作开展的全国性出生缺陷项目的主要贡献者
预防研究(NBDPS)和评估妊娠暴露的出生缺陷研究I
(BD--第一步)自1996年以来。NYCBDRP研究人员已经使用了NBDPS/BD-STEP I数据
广泛研究BD的三个主要重点领域--步骤二:急性疾病,如
感染;慢性疾病,如自身免疫性疾病、高血压和哮喘;以及
治疗这些疾病的药物。NYCBDRP拥有一支经验丰富的团队
成功实施拟议研究的所有方面:病例和对照调查,
临床和联系信息摘要和审查、受试者招募、新生儿
血迹采集,与国家传染病监测系统的联系,与
纽约州所有付款人数据库(APD),以验证自我报告的药物使用情况,以及
创新流行病学调查。NYCBDRP的研究议程将集中在
使用新的BD-STEP问题扩展药物分析,开发分析方法以
确定罕见缺陷的危险因素和共同发生的出生缺陷的模式,并探索
慢性疾病和治疗对出生缺陷风险的联合影响。拟议的试点
验证研究将建立在NYCBDRP主题专业知识的基础上,重点是
抗高血压药物的使用。通过与奥尔巴尼大学的密切关系
公共卫生学院,NYCBDRP将继续吸引和指导研究生水平
学生使用NBDPS/BD-STEPS数据进行硕士和论文项目。来自ITS
在纽约州卫生局(NYSDOH)任职,NYCBDRP将
通过捐赠员工时间利用大量NYDOH资源,特权访问
个人病历、先天畸形登记处、传染病
监控系统和警察局,以及与世界著名的沃兹沃斯中心的联系
基因研究实验室。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Marilyn L. Browne其他文献
MATERNAL, REPRODUCTIVE, AND PERINATAL FACTORS AND THE RISKS OF BIRTH DEFECTS
- DOI:
10.1016/j.fertnstert.2023.08.606 - 发表时间:
2023-10-01 - 期刊:
- 影响因子:
- 作者:
Barbara Luke;Marilyn L. Browne;Sarah C. Fisher;Nina E. Forestieri;Hafsatou Diop;Caitlin R. Sacha;Gayathree Murugappan;Katherine E. Cameron;Valerie L. Baker;Melissa A. Richard;Philip J. Lupo - 通讯作者:
Philip J. Lupo
Interaction of maternal medication use with ambient heat exposure on congenital heart defects in the National Birth Defects Prevention Study
国家出生缺陷预防研究中母亲用药与环境热暴露对先天性心脏病的相互作用
- DOI:
10.1016/j.envres.2022.114217 - 发表时间:
2022 - 期刊:
- 影响因子:8.3
- 作者:
Yanqiu Ou;Eleni A. Papadopoulos;Sarah C. Fisher;Marilyn L. Browne;Ziqiang Lin;Aida Soim;Yi Lu;Scott Sheridan;Jennita Reefhuis;Peter H. Langlois;Paul A. Romitti;Erin M. Bell;Marcia L. Feldkamp;Sadia Malik;Shao Lin - 通讯作者:
Shao Lin
Marilyn L. Browne的其他文献
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{{ truncateString('Marilyn L. Browne', 18)}}的其他基金
New York State BD-STEPS: Component A and B
纽约州 BD-STEPS:A 部分和 B 部分
- 批准号:
10764615 - 财政年份:2023
- 资助金额:
$ 90万 - 项目类别:
New York State Component A: BD-STEPS II Core
纽约州 A 部分:BD-STEPS II 核心
- 批准号:
9766980 - 财政年份:2018
- 资助金额:
$ 90万 - 项目类别:
New York Center for Birth Defects Research and Prevention
纽约出生缺陷研究与预防中心
- 批准号:
8400867 - 财政年份:2008
- 资助金额:
$ 90万 - 项目类别:
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