New York State BD-STEPS

描述（由申请人提供）：本项目的目的是确定怀孕早期可改变的母体暴露，这些暴露可能增加受某些重大结构性出生缺陷影响的妊娠风险。受助人将使用现有出生缺陷监测系统的数据来识别患有17种出生缺陷的儿童。将联系这些病例婴儿的母亲和随机选择的活产对照婴儿的母亲，并邀请其参加母亲访谈。访谈将重点关注以下关键领域：（）糖尿病、肥胖和体力活动;（2）其他慢性孕产妇疾病;（3）不孕症;（4）药物使用;此外还有其他具有预防潜力的风险，如泌尿生殖系统感染、发烧和孕产妇职业。将向参与的家庭邮寄试剂盒，以收集唾液样本，并将为收集残留的新生儿血斑提供经费，以提高基因-环境相互作用研究的潜力。

DESCRIPTION (provided by applicant): The purpose of this project is to identify modifiable maternal exposures in early pregnancy that may increase the risk for having a pregnancy affected by certain major, structural birth defects. Grantees will use data from existing birth defects surveillance systems to identify children with the 17 birth defects categories. Mothers of these case infants and mothers of randomly selected live born control infants will be contacted and invited to participate in a maternal interview. The interview will focus on the key areas of: () diabetes, obesity, and physical activity; (2) other chronic maternal medical conditions; (3) infertility; and (4) medication use; in addition to other exposures with promising prevention potential such as genitourinary infections, fever, and maternal occupation. Kits will be mailed to participating families to collect saliva samples and provisions will be made for the collection of residual newborn bloodspots, enhancing the potential for gene-environment interaction studies.