Component A: BD-STEPS Core at the NC Center for Birth Defects Research and Prevention

组件 A：北卡罗来纳州出生缺陷研究和预防中心的 BD-STEPS 核心

• 批准号: 10765328
• 负责人: Tania A. Desrosiers
• 金额: $ 60万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10765328
• 关键词: Component; BD; STEPS; Core; NC

Project Abstract Component A: BD-STEPS Core at the NC Center for Birth Defects Research and Prevention Birth defects are a leading cause of infant mortality and childhood morbidity, yet the etiology of most cases is unknown. Established in 2002 with funding from the CDC, the North Carolina Center for Birth Defects Research and Prevention (NCCBDRP) has been a major contributor to the National Birth Defects Prevention Study (NBDPS) and Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS). The next phase of BD-STEPS will continue to build on these important multi-site, population-based case-control studies to identify novel epidemiologic and genetic risk factors for major structural birth defects that can be translated into prevention strategies. The NCCBDRP's Specific Aims are to (1) Implement the BD-STEPS Core protocol in North Carolina including: (a) Utilize the existing state-wide, population-based birth defects surveillance system in NC to actively ascertain at least 150 cases per year among livebirths, stillbirths and elective abortions with a study-eligible birth defect in the demographically diverse 33-county study area; (b) Utilize birth certificates to identify an eligible population-based sample of approximately 100 control infants per year born in the same study area; (c) Conduct clinical case review and classification by clinical geneticist and pediatric cardiologist using abstracted medical records; (d) Partner with CDC's central interviewing contractor to facilitate NC participation in the core interview and online occupational survey; (e) Conduct supplemental data collection about reportable infections before and during pregnancy; (f) Conduct supplemental biospecimen collection of residual newborn blood spots; (2) Establish a unique data resource for investigating prescription medication use during pregnancy and birth defects by linking BD-STEPS and NBDPS participants in NC with health insurance claims records from NC Medicaid and Blue Cross Blue Shield NC; (3) Establish a unique biospecimen resource for investigating prenatal environmental exposures and birth defects by collecting shed deciduous teeth from BD-STEPS and NBDPS participants in NC; (4) Leverage the NCCBDRP's well- established group of investigators and collaborators to develop innovative, high-impact studies with BD-STEPS and NBDPS data on genetics, epigenetics, and gene-exposure interactions associated with birth defects, and epidemiologic risk factors for birth defects including medication use during pregnancy, maternal chronic and infectious disease, and key social determinants of health such as individual- and neighborhood-level socioeconomic factors, acculturation, employment and workplace conditions, and environmental factors; (5) Produce at least seven NC-led manuscripts for publication in high-impact journals using pooled data from BD- STEPS and/or NBDPS during the 3.5-year award period; and (6) Continue our long-standing, successful training program in birth defects epidemiology.

项目摘要 组件A：NC出生缺陷研究和预防中心的BD-STEPS核心 出生缺陷是婴儿死亡和儿童发病的主要原因，但大多数病例的病因是 未知北卡罗来纳州出生缺陷中心成立于2002年，由疾病预防控制中心提供资金 研究和预防（NCCBDRP）一直是国家出生缺陷预防的主要贡献者 研究（NBDPS）和出生缺陷研究，以评估妊娠期流产（BD-STEPS）。下一阶段 BD-STEPS将继续在这些重要的多中心、基于人群的病例对照研究的基础上， 主要结构性出生缺陷的新流行病学和遗传风险因素，可转化为 预防战略。NCCBDRP的具体目标是：（1）实现BD-STEPS核心协议 北卡罗来纳州，包括：（a）利用现有的全州范围的、以人口为基础的出生缺陷监测系统 在NC，每年积极查明至少150例活产、死产和选择性堕胎， 在人口统计学上多样化的33个县研究区域中符合研究条件的出生缺陷;（B）利用出生证明， 确定一个合格的基于人口的样本，每年约有100名对照婴儿出生在同一个国家， （c）由临床遗传学家和儿科心脏病专家进行临床病例审查和分类 （d）与疾病预防控制中心的中央访谈承包商合作，以促进NC 参加核心访谈和在线职业调查;（e）收集补充数据 关于怀孕前和怀孕期间可报告的感染;（f）进行补充生物标本采集， 新生儿血斑残留;（2）建立调查处方药的独特数据资源 通过将NC中的BD-STEPS和NBDPS参与者与健康联系起来， 来自NC Medicaid和Blue Cross Blue Shield NC的保险索赔记录;（3）建立唯一的 产前环境暴露与出生缺陷调查用生物标本资源采集棚 从BD-STEPS和NBDPS参与者在NC的乳牙;（4）利用NCCBDRP的良好- 成立了一个研究者和合作者小组，利用BD-STEPS开发创新的、高影响力的研究 和NBDPS关于与出生缺陷相关的遗传学、表观遗传学和基因暴露相互作用的数据，以及 出生缺陷的流行病学危险因素，包括妊娠期药物使用、母亲慢性和 传染病和健康的关键社会决定因素，如个人和社区一级 社会经济因素，文化适应，就业和工作场所条件，以及环境因素;（5） 使用BD的汇总数据制作至少七篇NC主导的手稿，以在高影响力期刊上发表- STEPS和/或NBDPS在3.5年的奖励期内;和（6）继续我们长期以来的，成功的 出生缺陷流行病学培训计划。