Administrative Supplement for A Multilevel Physical Activity Intervention for South Asian Women and Girls

南亚妇女和女童多层次体育活动干预行政补充

• 批准号: 10771843
• 负责人: NAMRATHA R KANDULA
• 金额: $ 22.13万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10771843
• 关键词: Administrative Supplement; Adolescent; Asian Americans; Clinical Research; Clinical Trials; Communities; Daughter; Doctor of Philosophy; Enrollment; Ethnic Origin; Female; Female Adolescents; Funding; Future; Gender; Gender Role; Goals; Interview; Knowledge; Mentors; Modeling; Mothers; Outcome; Parents; Participant; Physical activity; Population Group; Population Heterogeneity; Prevention Research; Principal Investigator; Randomized, Controlled Trials; Research; Research Personnel; Research Subjects; Scientific Advances and Accomplishments; South Asian; Strategic Planning; Structure; United States National Institutes of Health; Woman; Women' s Health; cancer prevention; disorder prevention; disparity reduction; evidence base; exercise intervention; experience; girls; health disparity; health equity; implementation strategy; improved; lens; male; moderate-to-vigorous physical activity; recruit; sex

PROJECT SUMMARY Women and adolescent girls of South Asian background experience multilevel barriers to physical activity (PA). The South Asians Active Together (SAATH) trial (R01CA242520) is an ongoing randomized controlled trial that has enrolled 172 South Asian (SA) American mothers and adolescent daughters to evaluate the effects of a dyadic physical activity (PA) intervention on moderate to vigorous PA in SA women and girls. The goal of this administrative supplement to the SAATH trial is to conduct new research to identify and develop replicable strategies to overcome gender-specific barriers that South Asian women experience to clinical research participation. Our team has extensive experience with community-engaged recruitment of South Asian Americans in clinical research; however, SA women and girls remain underrepresented in PA and cancer prevention research despite persistent health disparities. Even with community-engaged recruitment approaches, there are strong differences between male and female participants regarding access to opportunities and multilevel influences on the decision to participate in clinical research. The research proposed in this supplement targets knowledge gaps about the influence and intersection of gender and ethnicity on implementation strategies to improve representation of SA women in clinical research. Specific Aims of this Administrative Supplement are to: 1) Identify how gendered roles, experiences, and identities influence access, participation, and inclusion as research subjects by performing and analyzing semi- structured interviews with SA mothers and daughters who did and did not participate in the SAATH trial (n=15 dyads); 2) Develop and evaluate replicable strategies using an intersectional lens and participatory action model for enhancing access and inclusion of SA women and adolescent girls in PA and cancer prevention research. This administrative supplement is led by Principal Investigator (PI) Namratha Kandula, MD, MPH and includes an early stage investigator, Milkie Vu, PhD who will be mentored by the Dr. Kandula to accomplish the scientific goals of the parent study and supplement. This administrative supplement will address Objective 1.2, Objective 2.4, and Objective 3.1of the Trans-NIH Strategic Plan for Women's Health Research, which seek to investigate the influence of sex and gender on disease prevention, presentation, management, and outcomes, improve the recruitment and retention of women underrepresented in clinical research, and disseminate and implement evidence-based strategies to improve women's health. Results new commitment from this supplement will provide knowledge about the intersection of gender and ethnicity to inform replicable strategies to improve of SA women and adolescents girls for future PA and cancer prevention studies.

项目概要 南亚背景的妇女和少女在身体活动 (PA) 方面经历多层次的障碍。 南亚人一起活跃 (SAATH) 试验 (R01CA242520) 是一项正在进行的随机对照试验， 已招募 172 名南亚裔 (SA) 美国母亲和青春期女儿来评估 对南澳妇女和女孩进行中度至剧烈体力活动 (PA) 干预。此举的目标 SAATH 试验的行政补充是进行新的研究，以确定和开发可复制的 克服南亚女性在临床研究中遇到的性别障碍的策略 参与。我们的团队在南亚裔社区参与招聘方面拥有丰富的经验 从事临床研究的美国人；然而，南澳妇女和女孩在 PA 和癌症领域的代表性仍然不足 尽管健康差距持续存在，但仍开展预防研究。即使有社区参与的招聘 的方法中，男性和女性参与者在获取信息方面存在很大差异 参与临床研究决定的机会和多层次影响。研究 本补编中提出的建议针对的是关于性别和性别的影响和交叉的知识差距。 种族问题，以提高南澳妇女在临床研究中的代表性。 本行政补充文件的具体目标是： 1) 确定性别角色、经验和 身份通过执行和分析半结构化数据来影响研究对象的获取、参与和包容 对参加和未参加 SAATH 试验的 SA 母亲和女儿进行结构化访谈（n=15） 成对的）； 2) 使用交叉视角和参与行动制定和评估可复制的策略 提高南澳妇女和少女参与公共活动和癌症预防的机会和参与度的模型 研究。本行政补充由首席研究员 (PI) Namratha Kandula（医学博士、公共卫生硕士）和 其中包括一位早期研究员 Milkie Vu 博士，他将在 Kandula 博士的指导下完成 家长学习的科学目标和补充。本行政补充文件将解决目标 1.2， 跨 NIH 女性健康研究战略计划的目标 2.4 和目标 3.1，旨在 调查性别和性别对疾病预防、表现、管理和结果的影响， 改善临床研究中代表性不足的女性的招募和保留，并传播和保留 实施循证战略以改善妇女健康。结果 新的 承诺 本补充品将提供 关于性别和种族交叉的知识，为可复制的战略提供信息，以改善 南澳妇女和少女的未来 PA 和癌症预防研究。