Administrative Supplement for A Multilevel Physical Activity Intervention for South Asian Women and Girls

项目摘要 南亚背景的妇女和少女在身体活动方面遇到多层次的障碍。 南亚人一起活动（SAATH）试验（R 01 CA 242520）是一项正在进行的随机对照试验， 招募了172名南亚（SA）美国母亲和青春期女儿，以评估 对SA妇女和女孩进行中度至剧烈PA的二元体力活动（PA）干预。这个目标 SAATH试验的行政补充是进行新的研究，以确定和开发可复制的 克服南亚妇女在临床研究中遇到的性别障碍的战略 参与的我们的团队拥有丰富的南亚社区参与招聘经验 临床研究中的美国人;然而，SA妇女和女孩在PA和癌症中的代表性仍然不足 尽管存在持续的健康差距，但预防研究。即使有社区参与的招聘， 在采取各种办法的情况下，男女参与者在获得 机会和多层次的影响，决定参加临床研究。研究 本补编提出的建议针对的是关于性别和 种族对实施战略，以提高临床研究中的SA妇女的代表性。 本行政补充文件的具体目标是：1）确定性别角色、经验和 身份通过执行和分析半研究来影响作为研究对象的获取、参与和包容 对参加和未参加SAATH试验的SA母亲和女儿进行结构化访谈（n=15 （2）利用交叉透镜和参与行动，制定和评价可复制的战略 促进南澳大利亚州妇女和少女参与公共卫生和癌症预防的模式 research.本行政补充由主要研究者（PI）Namratha Kandula，MD，MPH和 包括一个早期阶段的研究者，Milkie Vu博士，他将由Kandula博士指导完成 父母研究和补充的科学目标。本行政补编将处理目标1.2， 跨NIH妇女健康研究战略计划的目标2.4和目标3.1， 调查性和性别对疾病预防、表现、管理和结果的影响， 改善临床研究中代表性不足的妇女的招聘和保留， 实施循证战略，改善妇女健康。结果 新 承诺 从这个补充将提供 了解性别和种族的交叉点，为可推广的战略提供信息， 为未来的PA和癌症预防研究提供了一个新的研究平台。

PROJECT SUMMARY Women and adolescent girls of South Asian background experience multilevel barriers to physical activity (PA). The South Asians Active Together (SAATH) trial (R01CA242520) is an ongoing randomized controlled trial that has enrolled 172 South Asian (SA) American mothers and adolescent daughters to evaluate the effects of a dyadic physical activity (PA) intervention on moderate to vigorous PA in SA women and girls. The goal of this administrative supplement to the SAATH trial is to conduct new research to identify and develop replicable strategies to overcome gender-specific barriers that South Asian women experience to clinical research participation. Our team has extensive experience with community-engaged recruitment of South Asian Americans in clinical research; however, SA women and girls remain underrepresented in PA and cancer prevention research despite persistent health disparities. Even with community-engaged recruitment approaches, there are strong differences between male and female participants regarding access to opportunities and multilevel influences on the decision to participate in clinical research. The research proposed in this supplement targets knowledge gaps about the influence and intersection of gender and ethnicity on implementation strategies to improve representation of SA women in clinical research. Specific Aims of this Administrative Supplement are to: 1) Identify how gendered roles, experiences, and identities influence access, participation, and inclusion as research subjects by performing and analyzing semi- structured interviews with SA mothers and daughters who did and did not participate in the SAATH trial (n=15 dyads); 2) Develop and evaluate replicable strategies using an intersectional lens and participatory action model for enhancing access and inclusion of SA women and adolescent girls in PA and cancer prevention research. This administrative supplement is led by Principal Investigator (PI) Namratha Kandula, MD, MPH and includes an early stage investigator, Milkie Vu, PhD who will be mentored by the Dr. Kandula to accomplish the scientific goals of the parent study and supplement. This administrative supplement will address Objective 1.2, Objective 2.4, and Objective 3.1of the Trans-NIH Strategic Plan for Women's Health Research, which seek to investigate the influence of sex and gender on disease prevention, presentation, management, and outcomes, improve the recruitment and retention of women underrepresented in clinical research, and disseminate and implement evidence-based strategies to improve women's health. Results new commitment from this supplement will provide knowledge about the intersection of gender and ethnicity to inform replicable strategies to improve of SA women and adolescents girls for future PA and cancer prevention studies.