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Mentoring in community engaged implementation research to reduce cardiovascular disparities

指导社区参与实施研究以减少心血管差异

基本信息

批准号：
10455407
负责人：
NAMRATHA R KANDULA
金额：
$ 12.15万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10455407
关键词：
Address Adolescent Adult Affect American Heart Association Americas Asian Americans Atherosclerosis Blood Pressure Cardiovascular Diseases Cardiovascular system Clinical Clinical Research Communities Daughter Diabetes Mellitus Diet East Asian Education Effectiveness Effectiveness of Interventions Enrollment Environment Ethnic group Evaluation Evidence based intervention Family Female Adolescents Funding Future Gender Glucose Goals Health Health Educators Health behavior Heart Diseases High Prevalence Hispanic Populations Hypertension Immigrant Immigration Income Individual Infrastructure Intervention Intervention Trial Knowledge Language Leadership Link Lipids Measures Mediator of activation protein Medicine Mentors Mentorship Methods Midcareer Investigator Award in Patient-Oriented Research Minority Modeling Mothers National Heart, Lung, and Blood Institute Neighborhood Health Center Neighborhoods Not Hispanic or Latino Outcome Participant Physical activity Population Prevention strategy Preventive Medicine Public Health Research Research Methodology Research Personnel Resources Risk Factors Scholarship Science South Asian Testing Time Training United States United States National Institutes of Health Universities Vulnerable Populations Weight Woman Work base cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health community based participatory research community burden community engaged research community partnership community setting contextual factors disease disparity effectiveness evaluation effectiveness outcome epidemiology study evidence base exercise intervention future implementation health care availability health disparity health disparity populations health equity healthy lifestyle high risk hybrid type 1 design implementation evaluation implementation outcomes implementation research implementation science implementation strategy improved innovation lifestyle intervention medical schools men mid-career faculty mortality next generation physical inactivity practice setting racial and ethnic research to practice skills social social determinants social health determinants social structure stakeholder perspectives student mentoring treatment research

项目摘要

PROJECT SUMMARY This is a proposal for a K24 Midcareer Investigator Award in Patient-Oriented Research (POR) for Namratha Kandula, MD, MPH of Northwestern University Feinberg School of Medicine. Dr. Kandula is Associate Professor of Medicine and Preventive Medicine and co-Director of the Center for Community Health. Dr. Kandula's scholarship is focused on understanding the social and cultural determinants of cardiovascular disease (CVD) disparities in South Asian Americans and implementing evidence-based interventions (EBIs) using community-based participatory research (CBPR) methods. South Asian Americans, the majority of whom are immigrants, are disproportionately affected by CVD compared to non-Hispanic whites and other Asian Americans. While there is ample evidence that intensive diet and physical activity interventions improve CVD risk factors in adults, these EBIs have limited reach in South Asian and other vulnerable populations because most EBIs were developed in narrow clinical populations, lack cultural salience, do not account for multilevel social determinants of health, and are difficult to implement in new settings. Dr. Kandula has expertise in epidemiologic studies and community-based lifestyle intervention trials and has been actively mentoring students and junior investigators on health disparities and community engaged research. The objective of this K24 application is to promote science and mentorship in community engaged implementation research to optimally deliver and sustain EBIs focused on populations with a high burden of health disparities. Support from the K24 will provide Dr. Kandula with protected time to: 1) Devote more time to mentoring a diverse group of young investigators in community engaged implementation research; 2) Improve her implementation science research and mentoring skills through mentor training and guidance from senior mentors; 3) Extend her currently funded work to fill critical gaps in the science of delivering and sustaining EBIs for vulnerable populations; and 4) Assume leadership in new multisector, collaborative research on how to optimally deliver EBIs to eliminate health disparities. The current K24 proposal builds upon the scientific premise and extends the research and mentorship of the PI in the context of her two NIH-funded, community engaged lifestyle intervention trials to reduce CVD disparities in South Asian adults and adolescents (SAHELI and SAATH trials). The PI and her mentees will use mixed methods to: 1) Investigate social and structural determinants that contributed to differences in implementation outcomes of EBIs in the SAHELI and SAATH trials; 2) Evaluate sustainability of the EBIs implemented in the SAHELI and SAATH trials; and 3) Understand stakeholder perspectives on which implementation outcomes and evaluation strategies are most meaningful and feasible when implementing EBIs for CVD prevention in health disparity populations. Conduct of the proposed Aims will accelerate science and mentorship in building sustainable community partnerships and models to optimally deliver EBIs that improve the health of vulnerable populations and advance health equity.

项目概要这是为 Namratha 颁发 K24 职业生涯中期研究员以患者为导向的研究 (POR) 奖的提案 Kandula，医学博士，西北大学范伯格医学院公共卫生硕士。 Kandula 博士是助理医学和预防医学教授兼社区健康中心联席主任。 Kandula 博士的学术重点是了解心血管疾病的社会和文化决定因素南亚裔美国人的疾病（CVD）差异和实施循证干预措施（EBI）使用基于社区的参与性研究（CBPR）方法。南亚裔美国人，其中大多数是移民，与非西班牙裔白人和其他亚洲人相比，受心血管疾病的影响更大美国人。虽然有充分证据表明强化饮食和体力活动干预可改善心血管疾病成人的危险因素，这些 EBI 在南亚和其他弱势群体中的影响有限，因为大多数 EBI 是在狭窄的临床人群中开发的，缺乏文化显着性，不考虑多层次健康的社会决定因素，并且很难在新环境中实施。 Kandula 博士拥有以下方面的专业知识：流行病学研究和基于社区的生活方式干预试验，并一直在积极指导学生和初级研究人员关注健康差异和社区参与研究。此举的目的 K24 应用程序旨在促进社区参与实施研究中的科学和指导以最佳方式提供和维持以健康差异负担较重的人群为重点的 EBI。支持 K24 将为 Kandula 博士提供受保护的时间来： 1) 投入更多时间指导多元化群体参与社区实施研究的年轻研究者的数量； 2）提高她的实施科学性通过导师培训和高级导师的指导获得研究和指导技能； 3）延长她的时间目前资助的工作旨在填补为弱势群体提供和维持 EBI 的科学领域的关键空白人口； 4) 在新的多部门协作研究中发挥领导作用，研究如何以最佳方式交付 EBI 旨在消除健康差异。当前的 K24 提案建立在科学前提之上，并扩展了 PI 在她的两项 NIH 资助的社区参与生活方式背景下的研究和指导减少南亚成人和青少年 CVD 差异的干预试验（SAHELI 和 SAATH 试验）。 PI 和她的学员将使用混合方法来： 1) 调查社会和结构决定因素这导致了 SAHELI 和 SAATH 试验中 EBI 实施结果的差异； 2) 评估 SAHELI 和 SAATH 试验中实施的 EBI 的可持续性； 3) 理解利益相关者认为哪些实施成果和评估策略最有意义在健康差异人群中实施 EBI 预防 CVD 时是可行的。的行为拟议的目标将加速建立可持续社区伙伴关系的科学和指导最佳地提供 EBI 的模型，以改善弱势群体的健康并促进健康公平。