Supplement for Community Translation of the South Asian Healthy Lifestyle Intervention (SAHELI)

南亚健康生活方式干预 (SAHELI) 社区翻译补充材料

• 批准号: 10588670
• 负责人: NAMRATHA R KANDULA
• 金额: $ 15.46万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10588670
• 关键词: Administrative Supplement; Adult; Asian Americans; Asian population; Behavioral; Cholesterol; Collection; Communities; Data; Databases; Diastolic blood pressure; Diet; Education; Enrollment; Evidence based intervention; Funding; Glycosylated Hemoglobin; Hybrids; Intervention; Intervention Studies; Intervention Trial; Knowledge; Mediator of activation protein; Outcome; Outcome Assessment; Participant; Physical activity; Population; Principal Investigator; Process; Public Health; Publications; Randomized Controlled Trials; Reporting; Research; Risk Factors; South Asian; Testing; Translations; Weight; base; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; clinical risk; community based participatory research; comparison group; ethnic minority; follow-up; health equity; healthy lifestyle; high risk; implementation evaluation; implementation outcomes; improved; intervention effect; lifestyle intervention; preventive intervention; primary outcome; psychosocial; racial minority

Project Summary The South Asian Healthy Lifestyle Intervention (SAHELI) is an ongoing Type 1 Hybrid randomized controlled trial that has enrolled 550 South Asian American adults with cardiovascular risk factors and is testing whether a 16-week community-based, culturally adapted lifestyle intervention or brief healthy lifestyle education can significantly improve cardiovascular risk factors. The study has completed enrollment and seeks funding for 12 additional months to complete follow-up outcome assessments, implementation evaluation, closeout, analysis, and presentations/publications. This administrative supplement is led by Principal Investigator (PI) Namratha Kandula, MD, MPH who will coordinate all post-enrollment activities to accomplish the scientific aims of the study. The SAHELI trial is the largest lifestyle intervention trial among South Asian Americans, a population that has a disproportionate risk of cardiovascular disease and is not being reached by prevention interventions. The funds from this administrative supplement will support completion of 6- and 12-month follow-up for 141 study participants, ongoing collection of implementation outcomes, database lock, analyses of study hypotheses, reporting, publication, and dissemination of trial results to scientific and community stakeholders. The Specific Aims of that SAHELI trial are to: 1) Determine whether participation in the SAHELI intervention is associated with significantly greater improvements in clinical risk factors associated with CVD (primary outcomes of systolic and diastolic blood pressure, cholesterol, glycated hemoglobin, and weight) relative to a comparison group that receives print education materials on healthy lifestyle at 12 months; and 2) Conduct a multi-stakeholder implementation evaluation to evaluate the SAHELI intervention and community-based participatory research process. In Secondary Aims, we will determine SAHELI's effect on behavioral and psychosocial outcomes, and examine mediators of intervention effect. There is an unmet need for evidence- based interventions that improve diet and physical activity and reduce cardiovascular disease risk among the U.S. South Asian population. Given the lack of effective and equitable lifestyle interventions for South Asian Americans at-risk for cardiovascular disease, completing the proposed research is of scientific and public health import.

项目摘要 南亚健康生活方式干预（Saheli）是一种持续的1型混合随机控制 试验已经招募了550名南亚美国成年人患有心血管危险因素，并且正在测试是否a是 以16周为基础的社区，文化适应的生活方式干预或简短的健康生活方式教育可以 显着改善心血管危险因素。该研究已完成入学率，并寻求12个 额外的几个月来完成后续结果评估，实施评估，结束，分析， 和演示/出版物。此行政补充由首席研究员（PI）Namratha领导 医学博士Kandula，MPH 学习。 Saheli试验是南亚美国人中最大的生活方式干预试验，人口 这具有心血管疾病的不成比例风险，预防干预措施没有达到。 该行政补充的资金将支持完成141的6个月和12个月的随访 研究参与者，持续的实施成果收集，数据库锁，研究分析 对科学和社区利益相关者的试验结果的假设，报告，出版和传播。 Saheli试验的具体目的是：1）确定参与Saheli干预是否是 与CVD相关的临床风险因素的改善显着改善（主要 相对于A的收缩压和舒张压，胆固醇，糖化血红蛋白和体重的结果）相对于A 比较小组在12个月时接受有关健康生活方式的印刷教育材料； 2）进行 多利益相关者实施评估，以评估Saheli干预和社区 参与性研究过程。在次要目标中，我们将确定萨赫利对行为的影响 社会心理结局，并检查干预效果的调解人。有未满足的证据 - 改善饮食和体育锻炼并降低心血管疾病风险的基于干预措施 美国南亚人口。鉴于南亚缺乏有效且公平的生活方式干预措施 美国人处于心血管疾病的危险中，完成拟议的研究是科学和公众的 健康进口。