STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL OF ALPHA-PINENE

本合同的目标是为国家毒理学计划(NTP)的危险识别(或危险评估)活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。该项目涉及通过吸入暴露对选定化学品进行慢性前期和慢性研究。14天和90天的研究报告已经提交给了偏氯乙烯和α-蒎烯。对偏氯乙烯进行了为期两年的研究，并作了报告。由于管理层决定不进行这项研究，针对α-蒎烯的为期2年的研究已被取消。 致癌性；毒性；生物测定；F344大鼠；B6C3F1小鼠；偏氯乙烯；α-蒎烯

The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification (or hazard assessment) activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. This project involves prechronic and chronic studies of selected chemicals via inhalation exposure. The 14-day and 90 day study reports have been submitted for vinylidene chloride and alpha-pinene. The 2-year study of vinylidene chloride has been completed and reported. The 2-year study for alpha-pinene has been canceled as a result of a management decision not to conduct the study. Keywords Carcinogenicity; toxicity; bioassay; F344 rats; B6C3F1 mice; vinylidene chloride; alpha-pinene