STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL OF ALPHA-PINENE

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The goal of this contract is to provide support of National Toxicology Program (NTP) hazard identification (or hazard assessment) activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. This project involves prechronic and chronic studies of selected chemicals via inhalation exposure. The 14-day and 90 day study reports have been submitted for vinylidene chloride and alpha-pinene. The 2-year study of vinylidene chloride has been completed and reported. The 2-year study for alpha-pinene has been canceled as a result of a management decision not to conduct the study. Keywords Carcinogenicity; toxicity; bioassay; F344 rats; B6C3F1 mice; vinylidene chloride; alpha-pinene