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中文摘要
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描述(由申请人提供):这笔赠款的目标是更换暖通空调(HVAC)机组,并升级用于布鲁克海文国家实验室(BNL)动物设施服务的环境控制和监测系统。该机构有改善动物护理和支持研究计划的服务的短期和长期目标。35个基础和临床应用实验室,加上许多外部用户,开展实验性放射治疗的动物研究;开发诊断和治疗癌症的新成像方法;研究许多疾病的神经影响,包括成瘾、注意力缺陷多动障碍、帕金森、阿尔茨海默氏症和其他衰老疾病,并确定这些疾病的遗传易感性;以及探索重离子、电离辐射的生理效应。BNL提供的实验设备的独特性使得这项工作在世界其他地方是不可能完成的。充分发挥作用的暖通空调系统对于动物设施工作人员维持适当的环境条件的能力至关重要,这不仅是为了满足法规要求,也是为了确保从这些动物那里获得的科学信息是可靠的和可重复的,并可以应用于他们正在建模的人类条件。 申请的资金将用于购买更换暖通空调机组、更换所有相关的加湿机组以及安装新的温度和湿度监测和控制系统。这些升级是必要的,以保持老龄动物设施的环境参数在必要的范围内,不仅满足监管要求,而且确保设施内饲养动物的最佳健康。
英文摘要
DESCRIPTION (provided by applicant): The objective of this grant is to replace a Heating-Ventilation-Air Conditioning (HVAC) unit and upgrade the environmental control and monitoring systems that are used to service the Brookhaven National Laboratory (BNL) animal facility. The institution has both short and long term goals to improve animal care and the services that support the research program. Thirty-five basic and clinically applied laboratories plus many outside users conduct animal research in experimental radiotherapy; in developing new imaging modalities to diagnose and treat cancers, studying the neurological effects of many diseases including addiction, attention deficit hyperactivity disorder, Parkinson's, Alzheimer's and other aging diseases and determining genetic susceptibilities to these maladies; and in exploring the physiological effects of heavy ion, ionizing radiation. The uniqueness of the experimental equipment available at the BNL makes much of this work impossible to do anywhere else in the world. An adequately functioning HVAC system is critical to the ability of the animal facility staff to maintain proper environmental conditions, not only to meet regulatory requirements but to assure that the scientific information obtained from these animals is reliable and repeatable and can be applied to the human conditions they are modeling. The requested funding will be used to purchase a replacement HVAC unit, replacement of all the associated humidification units, and installation of new temperature and humidity monitoring and control systems. These upgrades are necessary to maintain the aging animal facility's environmental parameters within the ranges necessary not only for regulatory requirements but to ensure optimum health of the animals housed within the facility.
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