ENGINEERING OF CANCER NANOTECHNOLOGIES FOR HIGH-THROUGHPUT FABRICATION

摘要纳米技术构成了NSBCC的技术核心， 基础癌症研究，并最终用于癌症患者的临床护理。然而，它们是相似的， 与其他“高”纳米技术相比，它们还不适合大规模生产。的许多问题 必须解决的问题需要基础科学和工程的混合-必须解决的问题 这些技术的商业化可能会发生。NSBCC的主要影响，以及 NCI的纳米技术目标，只有当工具和技术，是在内部开发的感觉 CCNE最终将被广泛使用，NSBCC处于一个非常有利的位置，可以开始规划 现在在这个项目中，我们研究了大规模生产的基础科学， 纳米传感器，我们确定复制过程，当充分发展，应该使大规模 制作。我们的目标还包括将这些纳米传感器与耐溶剂和生物污损的 微流体，以及这些传感器相对于我们的黄金标准的绝对定量，这将 可以是使用特定定量ICAT质谱技术测量的一组血清蛋白。 这个项目的目标是使我们的纳米技术广泛应用于癌症 研究人员和癌症临床医生。

Abstract The nanotechnologies that form the technology core of the NSBCC are enabling devices for both fundamental cancer research, and eventually for clinical care of cancer patients. However, they are similar to other 'high' nanotechnologies - they are not yet amenable to mass production. Many of the issues that must be solved require a mixture of fundamental science and engineering - problems that must be solved before commercialization of these technologies is likely to occur. The major impact of the NSBCC, and of the NCI's nanotechnology goals, will only be felt if the tools and technologies that are developed within the CCNE's are eventually made broadly available, and the NSBCC is in a terrific position to start planning for that right now. In this Project, we work out the fundamental science behind the mass production of nanosensors and we identify replication processes that, when fully developed, should enable mass productions. Our aims also include the integration of those nanosensors with solvent and biofouling-resistant microfluidics, and the absolute quantitation of those sensors against our gold standard, which will be a panel of serum-proteins measured using a particular quantitative ICAT mass spectrometry technique. The goal of this project is to enable the wide-spread application of our nanotechnologies to cancer researchers and to the cancer clinicians.