QUANTITATIVE IMAGE ANALYSIS SPECIALIZED RESOURCE CORE

定量图像分析专业资源核心

• 批准号: 7918211
• 负责人: HENRY SUNG-CHENG HUANG
• 金额: $ 4.88万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7918211
• 关键词: Accounting; Affect; Algorithms; Animals; Archives; Beds; Biological Markers; Biology; Body Size; Cancer Center; Categories; Communication; Computer Systems; Computer software; Computers; Consultations; Core Facility; Coupled; Data; Development; Devices; Educational process of instructing; Ensure; Experimental Designs; Feedback; Funding; Funding Agency; Image; Image Analysis; Individual; Internet; Joints; Kinetics; Knowledge; Link; Maintenance; Malignant Neoplasms; Mathematics; Measurement; Methods; Modeling; NIH Grants and Contracts; Operative Surgical Procedures; Physics; Positioning Attribute; Positron-Emission Tomography; Procedures; Process; Protocols documentation; Radioactivity; Radiolabeled; Reliability of Results; Research Personnel; Resolution; Resources; Retrieval; Software Tools; Source; Specialist; System; Test Result; Time; Tissues; Tracer; Training; Training Programs; Tumor Tissue; Work; Writing; base; cancer imaging; image archival system; image reconstruction; imaging modality; imaging probe; improved; in vivo Cellular and Molecular Imaging Centers; interest; meetings; member; molecular imaging; nanosystems; programs; radiotracer; research study; tool; tumor; uptake

C3. QUANTITATIVE IMAGE ANALYSIS CORE FACILITY (Core #4) C3.1. Introduction The Quantitative Image Analysis Specialized Resource (QIASR) facility provides image analysis capability to imaging researchers in several projects, including the DOE-IMED lab, the UCLAICMIC, and the NSBCC. Activities supported include consultation, training, image archival, providing software, and direct image analysis assistance that can be grouped into two functional categories¿technical support and scientific support. The technical support helps investigators in image archival/retrieval and general computation. Technical support is essential for all imaging studies; acquired images (microPET, microCT, etc.) gathered in all projects must be archived in orderly and accessible fashion, made available on demand and conveniently shared. These objectives are accomplished with the help of a "picture archival and communication system" (PACS) for animal images that was been developed within the NCI-funded ICMIC program. Assistance from the QIASR ranges from experimental design to methods of image analysis and data interpretation. The image acquisition is handled by the Molecular Imaging Core (MISR) (¿C3.), the acquired images need to be examined and analyzed to test if the results support the hypotheses. This is particularly true for the PET studies, where quantitative analysis of the image data, using kinetic modeling methods, helps bring out information more directly related to the basic processes/mechanisms involved in tracer uptake/clearance (Huang and Phelps 1985). The NSBCC will make most use of microPET analysis of radiolabeled cancer imaging probes and biomarkers. Through its ability to tease out confounding factors, quantitative analysis reduces variability of measurements and enables investigators to perform fewer animal studies to reach a conclusion. The QIA-provided assistance is particularly essential to investigators not familiar with the physics and mathematics necessary to ensure that the correct results are obtained from the imaging experiments. The QIASR training program is coupled with the use of effective software tools, and includes the offering of individual consultation/training sessions, seminars and online teaching software (see ¿C4.3 below on KIS). The training is carried out in coordination with the MISR to give investigators an integrated and comprehensive knowledge from experimental design to image acquisition to image analysis and interpretation. This Core and the MISR are highly inter-linked in their daily activities to provide support to investigators through the constant improvement of software tools, based on user feedback, and the implementation of new analysis methods to simplify analysis of acquired imaging data and to increase the reliability of the results. The most fundamental tools developed by the QIASR and their utilization are often presented to investigators through joint training sessions and consultations with researchers using the MISR; access to expertise, software and consultation is essentially seamless for these facilities in many instances. Resources of this facility are utilized both by the DoE supported projects, the ICMIC projects, and the proposed NSBCC projects in an approximate utilization ratio of 6-to-3-to1. The estimated NSBCC usage distribution is shown in Table C3.1.

C3.定量图像分析核心设施（核心#4） C3.1.介绍定量图像分析专业资源（QIASR）设施提供 图像分析能力的成像研究人员在几个项目，包括能源部-IMED实验室，UCLAICMIC， 和NSBCC。支持的活动包括咨询、培训、图像存档、提供软件， 和直接图像分析协助，可分为两个功能类别：技术支持 和科学支持。技术支持帮助研究者进行图像存档/检索和一般 计算技术支持对于所有成像研究至关重要;采集的图像（microPET、microCT等） 所有项目中收集的数据必须以有序和可访问的方式存档，并应要求提供， 方便分享。这些目标是在“图片档案和 在NCI资助的ICMIC内开发的用于动物图像的“PACS”通信系统 程序. QIASR的帮助范围从实验设计到图像分析和数据方法 解释。图像采集由分子成像核心（MISR）（² C3.）处理，所获取的 需要检查和分析图像以测试结果是否支持假设。这是特别 对于PET研究，使用动力学建模方法对图像数据进行定量分析有助于 提供与跟踪器中涉及的基本过程/机制更直接相关的信息 吸收/清除（Huang和Phelps 1985）。NSBCC将充分利用microPET分析， 放射性标记的癌症成像探针和生物标记物。通过梳理出混杂因素的能力， 定量分析减少了测量的变异性，使研究者能够进行更少的动物实验， 研究得出结论。QIA提供的援助对调查人员特别重要， 熟悉必要的物理和数学，以确保从 成像实验 QIASR培训计划与有效的软件工具的使用相结合，包括提供 个人咨询/培训课程、研讨会和在线教学软件（见下文关于知识创新系统的C4.3）。 培训是与MISR协调进行的，以便为调查人员提供综合全面的 从实验设计到图像采集再到图像分析和解释的知识。 该核心和MISR在日常活动中高度相互关联，为调查人员提供支持 通过对软件工具的不断改进，根据用户的反馈，并实施新的 分析方法，以简化对所采集的成像数据的分析并增加结果的可靠性。的 由QIASR开发的最基本的工具及其使用经常被介绍给研究人员 通过联合培训课程和与使用MISR的研究人员的磋商;获得专业知识， 在许多情况下，这些设施的软件和咨询基本上是无缝的。 能源部支助的项目、国际化学品和工业理事会项目以及拟议的 NSBCC项目的利用率约为6比3比1。估计的NSBCC使用分布为 见表C3.1。