QUANTITATIVE IMAGE ANALYSIS SPECIALIZED RESOURCE CORE

C3。定量图像分析核心设施(核心#4) C3.1。定量图像分析专业资源(QIASR)工具简介提供 为几个项目的成像研究人员提供图像分析能力，包括能源部-IMED实验室、加州大学洛杉矶分校 和NSBCC。支持的活动包括咨询、培训、图像存档、提供软件、 和直接图像分析协助，可分为两个职能类别：技术支持 和科学支持。该技术支持帮助调查人员在图像归档/检索和一般 计算。技术支持是所有成像研究必不可少的；获取的图像(microPET、microCT等) 在所有项目中收集的信息必须以有序和可访问的方式进行归档，并按需提供 方便地共享。这些目标是在“图片档案和 NCI资助的ICMIC开发的动物图像通信系统(PACS) 程序。 QIASR的帮助范围从实验设计到图像分析和数据的方法 释义。图像采集由分子成像核心(MISR)(？C3)处理，被采集的 需要对图像进行检查和分析，以测试结果是否支持假设。这是特别的 对于正电子发射计算机断层扫描研究是正确的，使用动力学建模方法对图像数据进行定量分析是有帮助的 提供与示踪剂所涉及的基本过程/机制更直接相关的信息 摄取/清除(Huang和菲尔普斯1985)。NSBCC将最大限度地利用MicroPET分析 放射性标记的癌症成像探针和生物标记物。通过它梳理混杂因素的能力， 定量分析减少了测量的可变性，使研究人员能够进行更少的动物实验 研究得出结论。卡塔尔投资局提供的协助对调查人员来说尤其重要 熟悉必要的物理和数学知识，以确保从 成像实验。 QIASR培训计划与有效软件工具的使用相结合，包括提供 个别咨询/培训课程、研讨会和在线教学软件(见下文关于KIS的C4.3)。 培训是在与MISR的协调下进行的，以便为调查人员提供综合和全面的 从实验设计到图像采集再到图像分析和解释的知识。 该中心和MISR在日常活动中高度相互联系，为调查人员提供支持 通过不断改进软件工具，根据用户反馈，实施新的 分析方法简化了对采集的成像数据的分析，并增加了结果的可靠性。这个 QIASR开发的大多数基本工具及其使用经常提交给调查人员 通过联合培训课程和与使用MISR的研究人员进行磋商；获得专业知识， 在许多情况下，这些设施的软件和咨询基本上是无缝的。 该设施的资源由能源部支持的项目、ICMIC项目和拟议的 NSBCC项目的利用率约为6：3：1。估计的NSBCC使用率分布为 如表C3.1所示。

C3. QUANTITATIVE IMAGE ANALYSIS CORE FACILITY (Core #4) C3.1. Introduction The Quantitative Image Analysis Specialized Resource (QIASR) facility provides image analysis capability to imaging researchers in several projects, including the DOE-IMED lab, the UCLAICMIC, and the NSBCC. Activities supported include consultation, training, image archival, providing software, and direct image analysis assistance that can be grouped into two functional categories¿technical support and scientific support. The technical support helps investigators in image archival/retrieval and general computation. Technical support is essential for all imaging studies; acquired images (microPET, microCT, etc.) gathered in all projects must be archived in orderly and accessible fashion, made available on demand and conveniently shared. These objectives are accomplished with the help of a "picture archival and communication system" (PACS) for animal images that was been developed within the NCI-funded ICMIC program. Assistance from the QIASR ranges from experimental design to methods of image analysis and data interpretation. The image acquisition is handled by the Molecular Imaging Core (MISR) (¿C3.), the acquired images need to be examined and analyzed to test if the results support the hypotheses. This is particularly true for the PET studies, where quantitative analysis of the image data, using kinetic modeling methods, helps bring out information more directly related to the basic processes/mechanisms involved in tracer uptake/clearance (Huang and Phelps 1985). The NSBCC will make most use of microPET analysis of radiolabeled cancer imaging probes and biomarkers. Through its ability to tease out confounding factors, quantitative analysis reduces variability of measurements and enables investigators to perform fewer animal studies to reach a conclusion. The QIA-provided assistance is particularly essential to investigators not familiar with the physics and mathematics necessary to ensure that the correct results are obtained from the imaging experiments. The QIASR training program is coupled with the use of effective software tools, and includes the offering of individual consultation/training sessions, seminars and online teaching software (see ¿C4.3 below on KIS). The training is carried out in coordination with the MISR to give investigators an integrated and comprehensive knowledge from experimental design to image acquisition to image analysis and interpretation. This Core and the MISR are highly inter-linked in their daily activities to provide support to investigators through the constant improvement of software tools, based on user feedback, and the implementation of new analysis methods to simplify analysis of acquired imaging data and to increase the reliability of the results. The most fundamental tools developed by the QIASR and their utilization are often presented to investigators through joint training sessions and consultations with researchers using the MISR; access to expertise, software and consultation is essentially seamless for these facilities in many instances. Resources of this facility are utilized both by the DoE supported projects, the ICMIC projects, and the proposed NSBCC projects in an approximate utilization ratio of 6-to-3-to1. The estimated NSBCC usage distribution is shown in Table C3.1.