Cortical control and biomechanics of tongue movement

舌头运动的皮质控制和生物力学

• 批准号: 10781477
• 负责人: Nicholas G Hatsopoulos
• 金额: $ 66.12万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10781477
• 关键词: 3-Dimensional; Automobile Driving; Behavior; Behavioral; Bilateral; Biomechanics; Brain; Complement; Data; Degenerative Disorder; Deglutition; Deglutition Disorders; Development; Diet Modification; Dysarthria; Electrodes; Elements; Exercise; Feeding behaviors; Food; Health; Human; Hydromorphone; Implant; Intramuscular; Jaw; Joints; Left; Link; Liquid substance; Macaca; Macaca mulatta; Malignant Neoplasms; Malnutrition; Mastication; Mechanics; Morbidity - disease rate; Motor Cortex; Movement; Muscle; Musculoskeletal System; Neurons; Neurosciences; Operative Surgical Procedures; Oral cavity; Organ; Patients; Pneumonia; Population; Property; Prosthesis; Quality of life; Research; Research Project Summaries; Role; Shapes; Signal Transduction; Solid; Speech; Stroke; Study models; System; Techniques; Testing; Tongue; Traction; Training; Variant; biomechanical model; biomechanical test; brain machine interface; drinking; exercise rehabilitation; feeding; grasp; human mortality; innovation; insight; kinematics; meetings; mind control; motor control; neural; neuroprosthesis; nonhuman primate; noninvasive brain stimulation; oral behavior; orofacial; pressure; rehabilitation strategy; sensory cortex; tongue biomechanics; tongue root

PROJECT SUMMARY This research will break new ground in sensorimotor neuroscience by relating cortical and muscle activity data to shape change in a soft-bodied organ, making it possible to evaluate the generalizability of basic principles of motor control across musculoskeletal systems. It will develop and test a computational biomechanical model of tongue function that relates muscle activity to tongue movements, complementing ongoing modeling studies of human tongues based on more limited kinematic and muscle activity data. By using variation in natural feeding behavior to elicit a range of hyolingual kinematics, the research will provide insight into the impact of dietary modification—a treatment for dysphagia—on hyolingual kinematics. This research will lay the groundwork for development of hyolingual neuroprostheses driven by cortical signals to facilitate chewing and swallowing after (e.g., cancer) surgery or degenerative diseases, and for better techniques for non-invasive brain stimulation, muscle stimulation, and rehabilitation exercises used in treatment of, e.g., dysphagia and dysarthria.

项目总结