Cortical control and biomechanics of tongue movement

舌头运动的皮质控制和生物力学

• 批准号: 10781477
• 负责人: Nicholas G Hatsopoulos
• 金额: $ 66.12万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10781477
• 关键词: 3-Dimensional; Automobile Driving; Behavior; Behavioral; Bilateral; Biomechanics; Brain; Complement; Data; Degenerative Disorder; Deglutition; Deglutition Disorders; Development; Diet Modification; Dysarthria; Electrodes; Elements; Exercise; Feeding behaviors; Food; Health; Human; Hydromorphone; Implant; Intramuscular; Jaw; Joints; Left; Link; Liquid substance; Macaca; Macaca mulatta; Malignant Neoplasms; Malnutrition; Mastication; Mechanics; Morbidity - disease rate; Motor Cortex; Movement; Muscle; Musculoskeletal System; Neurons; Neurosciences; Operative Surgical Procedures; Oral cavity; Organ; Patients; Pneumonia; Population; Property; Prosthesis; Quality of life; Research; Research Project Summaries; Role; Shapes; Signal Transduction; Solid; Speech; Stroke; Study models; System; Techniques; Testing; Tongue; Traction; Training; Variant; biomechanical model; biomechanical test; brain machine interface; drinking; exercise rehabilitation; feeding; grasp; human mortality; innovation; insight; kinematics; meetings; mind control; motor control; neural; neuroprosthesis; nonhuman primate; noninvasive brain stimulation; oral behavior; orofacial; pressure; rehabilitation strategy; sensory cortex; tongue biomechanics; tongue root

PROJECT SUMMARY This research will break new ground in sensorimotor neuroscience by relating cortical and muscle activity data to shape change in a soft-bodied organ, making it possible to evaluate the generalizability of basic principles of motor control across musculoskeletal systems. It will develop and test a computational biomechanical model of tongue function that relates muscle activity to tongue movements, complementing ongoing modeling studies of human tongues based on more limited kinematic and muscle activity data. By using variation in natural feeding behavior to elicit a range of hyolingual kinematics, the research will provide insight into the impact of dietary modification—a treatment for dysphagia—on hyolingual kinematics. This research will lay the groundwork for development of hyolingual neuroprostheses driven by cortical signals to facilitate chewing and swallowing after (e.g., cancer) surgery or degenerative diseases, and for better techniques for non-invasive brain stimulation, muscle stimulation, and rehabilitation exercises used in treatment of, e.g., dysphagia and dysarthria.

项目摘要 这项研究将通过将皮层和肌肉活动数据联系起来， 在软体器官的形状变化，使其有可能评估的基本原则的普遍性， 肌肉骨骼系统的运动控制。它将开发和测试一个计算生物力学模型， 舌头功能，将肌肉活动与舌头运动联系起来，补充了正在进行的建模研究， 基于更有限的运动学和肌肉活动数据的人类舌头。通过利用自然喂养的变化 行为，以引起一系列的舌运动学，研究将提供深入了解饮食的影响， 改良--吞咽困难的治疗--关于舌运动学。这项研究将奠定基础， 皮质信号驱动的舌骨舌神经假体的开发，以促进术后咀嚼和吞咽 (e.g.,癌症）手术或退行性疾病，以及用于非侵入性脑刺激的更好技术， 肌肉刺激和用于治疗的康复锻炼，例如，吞咽困难和构音障碍。