Cortical control and biomechanics of tongue movement

舌头运动的皮质控制和生物力学

• 批准号: 10781477
• 负责人: Nicholas G Hatsopoulos
• 金额: $ 66.12万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10781477
• 关键词: 3-Dimensional; Automobile Driving; Behavior; Behavioral; Bilateral; Biomechanics; Brain; Complement; Data; Degenerative Disorder; Deglutition; Deglutition Disorders; Development; Diet Modification; Dysarthria; Electrodes; Elements; Exercise; Feeding behaviors; Food; Health; Human; Hydromorphone; Implant; Intramuscular; Jaw; Joints; Left; Link; Liquid substance; Macaca; Macaca mulatta; Malignant Neoplasms; Malnutrition; Mastication; Mechanics; Morbidity - disease rate; Motor Cortex; Movement; Muscle; Musculoskeletal System; Neurons; Neurosciences; Operative Surgical Procedures; Oral cavity; Organ; Patients; Pneumonia; Population; Property; Prosthesis; Quality of life; Research; Research Project Summaries; Role; Shapes; Signal Transduction; Solid; Speech; Stroke; Study models; System; Techniques; Testing; Tongue; Traction; Training; Variant; biomechanical model; biomechanical test; brain machine interface; drinking; exercise rehabilitation; feeding; grasp; human mortality; innovation; insight; kinematics; meetings; mind control; motor control; neural; neuroprosthesis; nonhuman primate; noninvasive brain stimulation; oral behavior; orofacial; pressure; rehabilitation strategy; sensory cortex; tongue biomechanics; tongue root

PROJECT SUMMARY This research will break new ground in sensorimotor neuroscience by relating cortical and muscle activity data to shape change in a soft-bodied organ, making it possible to evaluate the generalizability of basic principles of motor control across musculoskeletal systems. It will develop and test a computational biomechanical model of tongue function that relates muscle activity to tongue movements, complementing ongoing modeling studies of human tongues based on more limited kinematic and muscle activity data. By using variation in natural feeding behavior to elicit a range of hyolingual kinematics, the research will provide insight into the impact of dietary modification—a treatment for dysphagia—on hyolingual kinematics. This research will lay the groundwork for development of hyolingual neuroprostheses driven by cortical signals to facilitate chewing and swallowing after (e.g., cancer) surgery or degenerative diseases, and for better techniques for non-invasive brain stimulation, muscle stimulation, and rehabilitation exercises used in treatment of, e.g., dysphagia and dysarthria.

项目总结 这项研究通过将大脑皮层和肌肉活动数据联系起来，将在感觉运动神经科学领域开辟新的天地。 在软体器官中的形状变化，使评估基本原理的概括性成为可能 整个肌肉骨骼系统的运动控制。它将开发和测试一个计算生物力学模型 舌头功能将肌肉活动与舌头运动联系起来，补充了正在进行的 基于更有限的运动学和肌肉活动数据的人类舌头。通过在自然喂养中使用变异 行为引发了一系列舌语运动学，这项研究将为深入了解饮食的影响提供依据 改良-吞咽困难的治疗-关于舌舌运动学。这项研究将为以下工作奠定基础 皮质信号驱动舌下神经假体的研制 (例如，癌症)手术或退行性疾病，以及用于非侵入性脑刺激的更好技术， 用于治疗吞咽困难和构音障碍的肌肉刺激和康复练习。