Intuitive, complete neural control of tablet computers for communication

皮质内脑-计算机接口(IBCI)具有恢复运动功能和 严重言语和运动障碍(SSMI)患者的沟通。而当 IBCI的潜在应用是巨大的，可能受益于IBCI的人数已经 没有被量化，也没有一种方法来量化对这个人口规模的估计 已经被开发出来了。 为了量化一个主要学术医学中心内可能受益于 一名IBCI，一名博士后将领导团队使用马萨诸塞州总医院 医院/布里格姆和妇女医院(MGB)研究患者数据登记处(RPDR)。这 数据库包括1975年以来700万名患者的所有MGB临床数据(30亿 相应的数据点[例如，诊断、程序等])。详细的临床记录将在 审查以确定个人受益于IBCI的可能性(例如，症状 严重程度、预后)。在我们的第一步中，我们将首先查询“锁定状态”的诊断代码 (LIS)，并制定一项战略，以确定IBCI对这些人的好处。团队将会 包括几位临床医生/神经学家评审员和研究PI；评价员之间的可靠性将是 评估过了。在完成最初的研究后，博士后研究员将询问其他 与通信和/或上肢功能障碍相关的ICD10/9诊断代码，采样a 统计上有效的病例子集，以确定IBCI受益于每个队列的可能性 病人。博士后研究员将向一位具有以下专业知识的生物统计学家学习并与其合作 神经疾病流行病学。接受特定疾病护理的人的百分比 在一个学术医学中心的诊断，以及谁可能从IBCI中受益，将 然后被用来推断更大人口中的发病率和流行率。 此外，博士后研究员将评估研究中的BrainGate神经的使用 通过接口系统的开发和实施，实现了调查评估系统 功效、可用性和使用频率。这些工具和分析将通过 当前和未来的BrainGate研究参与者，将对展示IBCI如何 技术可能会使未来的用户受益，并确定未来所需的功能和应用。 重要的是，由本副刊支持的博士后研究员也将促进 与健康相关的研究，为表演和内容带来批判性观点 以恢复交流的研究。

Intracortical brain-computer interfaces (iBCIs) have the potential to restore motor function and communication for individuals with severe speech and motor impairment (SSMI). While the potential applications of iBCIs are vast, the number of people who may benefit from an iBCI has not been quantified, nor has a methodology that quantifies an estimate of this population size been developed. To quantify the number of people within a major academic medical center who may benefit from an iBCI, a postdoctoral fellow will lead the team in use of the Massachusetts General Hospital/Brigham and Women’s Hospital (MGB) Research Patient Data Registry (RPDR). This database consists of all MGB clinical data from 7 million patients since 1975 (3 billion corresponding datapoints [e.g., diagnoses, procedures, etc.]). Detailed clinical records will be reviewed to determine the likelihood of an individual benefitting from an iBCI (e.g., symptom severity, prognosis). In our first step, we will first query the diagnosis codes for “locked-in state” (LIS) and develop a strategy to characterize iBCI benefit of these individuals. The team will include several clinician/neuroscientist reviewers and the study PI; inter-rater reliability will be assessed. After completing that initial study, the postdoctoral fellow will query additional ICD10/9 diagnosis codes relevant to communication and/or upper extremity deficits, sampling a statistically valid subset of cases to determine the likelihood of iBCI benefit for each cohort of patients. The postdoctoral fellow will learn from and work with a biostatistician with expertise in neurologic disease epidemiology. The percentages of people who received care for specific diagnoses at one academic medical center, and who would potentially benefit from an iBCI, will then be used to extrapolate incidence and prevalence in larger populations. Additionally, the postdoctoral fellow will evaluate the use of the investigational BrainGate neural interface system through the development and implementation of surveys that assess system efficacy, usability, and frequency of usage. These tools and analyses will be conducted with current and future BrainGate study participants, and will be valuable to demonstrate how iBCI technology may benefit future users, and to identify future desired features and applications. Importantly, the postdoctoral fellow supported by this supplement will also promote diversity in health-related research, bringing critical perspectives to both the performance and the content of research to restore communication.