Development of a Personalized Intervention to Motivate Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease

制定个性化干预措施以激励有阿尔茨海默病风险的中年成年人改变健康行为

• 批准号: 10783350
• 负责人: JENNIFER D DAVIS
• 金额: $ 9万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10783350
• 关键词: Adherence; Administrative Supplement; Adult; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Award; Belief; Clinical; Cognitive; Development; Diet; Educational Intervention; Elderly; Funding; Goals; Health; Health Sciences; Health behavior; Health behavior change; Health education; Impaired cognition; Individual; Intervention; Life Style Modification; Mentors; Mentorship; Neuropsychology; Parents; Participant; Persons; Physical activity; Population; Population Heterogeneity; Postbaccalaureate; Prevention trial; Protocols documentation; Psyche structure; Qualitative Methods; Reporting; Research Project Grants; Resources; Risk; Risk Factors; Science; Stress; Training; behavior change; career; community based participatory research; experience; good diet; health belief; interest; method development; middle age; modifiable risk; parent project; personalized intervention; prevent; programs; racism; recruit; social health determinants; stress reduction; structural determinants; therapy development

PROJECT ABSTRACT Modifiable risk factors such as physical activity, healthy diet, stress reduction, and cognitive stimulation are associated with lower risk of Alzheimer’s disease (AD) and related dementias. Population-level engagement in positive health behaviors in midlife and early late life is low, and large, multi-domain prevention trials have reported a positive impact of lifestyle modification on risk for cognitive decline. However, adherence to trial protocols is poor despite intensive individualized coaching, raising concern about generalizability and the ability to motivate sustained behavior change. The objective of the funded parent award is to use the science of behavior change to develop a theoretically grounded, personalized health education intervention that will motivate sustained health behavior change to prevent or delay the onset of Alzheimer’s disease (AD). The goal of this administrative supplement is to prepare Ms. Idania Arias, BA, for the next stage of her career by providing mentored training in qualitative methods and intervention development. Ms. Arias is an exceptional post-baccalaureate candidate from a background under-represented in the health sciences. Ms. Arias will complete a research project that builds upon the parent project by understanding the relationship between individual health beliefs and structural barriers to health behavior change. Under mentorship of study MPIs, she will use qualitative methods to assess the degree to which participants interested in a health behavior change program endorse structural barriers to behavior change (Aim 1) and characterize the interaction between individual health beliefs and structural barriers (Aim 2). Results will inform development of an enhanced healthy living education intervention. This proposal also includes a detailed training plan that will help Ms. Arias 1) develop expertise in qualitative methods; 2) gain experience in community-based participatory research to promote recruitment of diverse populations; and 3) engage in professional development opportunities to prepare her for graduate training in clinical neuropsychology.

项目摘要 可修改的危险因素，例如体育活动，健康饮食，减轻压力和认知刺激是 与阿尔茨海默氏病（AD）和相关痴呆症的较低风险有关。人口级参与 中年和后期的积极健康行为较低，大型多域预防试验具有 报道了生活方式改变对认知能力下降的风险的积极影响。但是，遵守审判 协议是剂量较差的强化个性化教练，引起了人们对概括性和能力的关注 激励持续的行为改变。资助的父母奖的目的是使用 行为改变以开发理论扎根的个性化健康教育干预措施 激励持续的健康行为改变，以防止或延迟阿尔茨海默氏病（AD）的发作。目标 这种行政补充是为了准备BA的Idania Arias女士，为她的下一阶段的职业生涯的下一阶段 提供定性方法和干预开发的指导培训。阿里亚斯女士是一个非凡的 来自卫生科学中代表性不足的背景的毕业后候选人。阿里亚斯女士威尔 通过了解 个人健康信念和健康行为改变的结构障碍。在研究MPI的精神状态下， 她将使用定性方法来评估参与者对健康行为感兴趣的程度 更改程序认可行为改变（AIM 1）的结构性障碍并表征互动 在个人健康信念和结构障碍之间（AIM 2）。结果将为发展提供信息 增强了健康的生活教育干预措施。该建议还包括一个详细的培训计划 帮助阿里亚斯女士1）开发定性方法方面的专业知识； 2）获得基于社区的经验 参与研究以促进招募潜水员人群； 3）从事专业 开发机会为她准备临床神经心理学的研究生培训。