Development of a Personalized Intervention to Motivate Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease

制定个性化干预措施以激励有阿尔茨海默病风险的中年成年人改变健康行为

• 批准号: 10783350
• 负责人: JENNIFER D DAVIS
• 金额: $ 9万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10783350
• 关键词: Adherence; Administrative Supplement; Adult; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Award; Belief; Clinical; Cognitive; Development; Diet; Educational Intervention; Elderly; Funding; Goals; Health; Health Sciences; Health behavior; Health behavior change; Health education; Impaired cognition; Individual; Intervention; Life Style Modification; Mentors; Mentorship; Neuropsychology; Parents; Participant; Persons; Physical activity; Population; Population Heterogeneity; Postbaccalaureate; Prevention trial; Protocols documentation; Psyche structure; Qualitative Methods; Reporting; Research Project Grants; Resources; Risk; Risk Factors; Science; Stress; Training; behavior change; career; community based participatory research; experience; good diet; health belief; interest; method development; middle age; modifiable risk; parent project; personalized intervention; prevent; programs; racism; recruit; social health determinants; stress reduction; structural determinants; therapy development

PROJECT ABSTRACT Modifiable risk factors such as physical activity, healthy diet, stress reduction, and cognitive stimulation are associated with lower risk of Alzheimer’s disease (AD) and related dementias. Population-level engagement in positive health behaviors in midlife and early late life is low, and large, multi-domain prevention trials have reported a positive impact of lifestyle modification on risk for cognitive decline. However, adherence to trial protocols is poor despite intensive individualized coaching, raising concern about generalizability and the ability to motivate sustained behavior change. The objective of the funded parent award is to use the science of behavior change to develop a theoretically grounded, personalized health education intervention that will motivate sustained health behavior change to prevent or delay the onset of Alzheimer’s disease (AD). The goal of this administrative supplement is to prepare Ms. Idania Arias, BA, for the next stage of her career by providing mentored training in qualitative methods and intervention development. Ms. Arias is an exceptional post-baccalaureate candidate from a background under-represented in the health sciences. Ms. Arias will complete a research project that builds upon the parent project by understanding the relationship between individual health beliefs and structural barriers to health behavior change. Under mentorship of study MPIs, she will use qualitative methods to assess the degree to which participants interested in a health behavior change program endorse structural barriers to behavior change (Aim 1) and characterize the interaction between individual health beliefs and structural barriers (Aim 2). Results will inform development of an enhanced healthy living education intervention. This proposal also includes a detailed training plan that will help Ms. Arias 1) develop expertise in qualitative methods; 2) gain experience in community-based participatory research to promote recruitment of diverse populations; and 3) engage in professional development opportunities to prepare her for graduate training in clinical neuropsychology.

项目摘要 可改变的风险因素，如体力活动，健康饮食，减轻压力和认知刺激， 与阿尔茨海默病（AD）和相关痴呆症的风险较低有关。人口参与 中年和晚年早期的积极健康行为很低，大型多领域预防试验 报告了生活方式改变对认知能力下降风险的积极影响。然而，坚持审判 尽管进行了密集的个性化辅导，但协议仍然很差，这引起了对普遍性和能力的担忧 来激发持续的行为改变。资助父母奖的目的是利用科学的 行为改变，制定一个理论上有根据的，个性化的健康教育干预， 促进持续的健康行为改变，以预防或延迟阿尔茨海默病（AD）的发作。目标 本行政补充的目的是为文学士Idania阿里亚斯女士的下一阶段职业生涯做好准备， 提供定性方法和干预措施制定方面的指导培训。阿里亚斯女士是一个例外 在健康科学方面，来自代表性不足的背景的学士后候选人。阿里亚斯女士将 完成一个研究项目，建立在父项目的理解之间的关系， 个人健康信念和健康行为改变的结构性障碍。在研究MPI的指导下， 她将使用定性方法来评估参与者对健康行为感兴趣的程度 改变计划认可行为改变的结构性障碍（目标1），并描述相互作用 个人健康信念和结构性障碍之间的关系（目标2）。研究结果将为开发 加强健康生活教育干预。该提案还包括一项详细的培训计划， 帮助阿里亚斯女士：1）发展定性方法专门知识; 2）获得以社区为基础的 参与性研究，以促进不同人群的招聘;和3）从事专业 发展机会，为她准备临床神经心理学的研究生培训。