Development of a Personalized Intervention to Motivate Health Behavior Change in Midlife Adults at Risk for Alzheimer's Disease

项目摘要 体力活动、健康饮食、减压和认知刺激等可改变的风险因素包括 与阿尔茨海默病(AD)和相关痴呆症的风险较低有关。人口层面的参与度 中年和晚年早期的积极健康行为较低，大型、多领域的预防试验 据报道，改变生活方式对认知能力下降的风险有积极影响。然而，坚持审判 尽管进行了密集的个性化训练，协议仍然很差，这引发了人们对通用性和能力的担忧 以激励持续的行为改变。资助家长奖的目标是利用 行为改变以发展理论上有根据的、个性化的健康教育干预，将 激励持续的健康行为改变，以预防或推迟阿尔茨海默病(AD)的发病。目标是 这一行政副刊的目的是使Idania Arias女士为其职业生涯的下一阶段做好准备，方法是 提供定性方法和干预发展方面的指导培训。阿里亚斯女士是一位杰出的 毕业后应聘者的背景在健康科学中的代表性不足。阿里亚斯女士将 通过了解父项目与父项目之间的关系来完成一个研究项目 个体健康信念和健康行为的结构性障碍发生变化。在学习MPI的指导下， 她将使用定性的方法来评估参与者对健康行为的兴趣程度 改变计划认可行为改变的结构性障碍(目标1)并描述相互作用 个人健康信念和结构性障碍之间的差距(目标2)。结果将为开发一个 加强健康生活教育干预。该提案还包括一份详细的培训计划，将 帮助Arias女士1)发展定性方法方面的专门知识；2)获得基于社区的经验 参与性研究，以促进招募不同的人口；和3)参与专业 为她的临床神经心理学研究生培训做好准备的发展机会。

PROJECT ABSTRACT Modifiable risk factors such as physical activity, healthy diet, stress reduction, and cognitive stimulation are associated with lower risk of Alzheimer’s disease (AD) and related dementias. Population-level engagement in positive health behaviors in midlife and early late life is low, and large, multi-domain prevention trials have reported a positive impact of lifestyle modification on risk for cognitive decline. However, adherence to trial protocols is poor despite intensive individualized coaching, raising concern about generalizability and the ability to motivate sustained behavior change. The objective of the funded parent award is to use the science of behavior change to develop a theoretically grounded, personalized health education intervention that will motivate sustained health behavior change to prevent or delay the onset of Alzheimer’s disease (AD). The goal of this administrative supplement is to prepare Ms. Idania Arias, BA, for the next stage of her career by providing mentored training in qualitative methods and intervention development. Ms. Arias is an exceptional post-baccalaureate candidate from a background under-represented in the health sciences. Ms. Arias will complete a research project that builds upon the parent project by understanding the relationship between individual health beliefs and structural barriers to health behavior change. Under mentorship of study MPIs, she will use qualitative methods to assess the degree to which participants interested in a health behavior change program endorse structural barriers to behavior change (Aim 1) and characterize the interaction between individual health beliefs and structural barriers (Aim 2). Results will inform development of an enhanced healthy living education intervention. This proposal also includes a detailed training plan that will help Ms. Arias 1) develop expertise in qualitative methods; 2) gain experience in community-based participatory research to promote recruitment of diverse populations; and 3) engage in professional development opportunities to prepare her for graduate training in clinical neuropsychology.