权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Influence of Strategy Training on Disability for Older Adults with Mild Cognitive Impairment

策略训练对轻度认知障碍老年人残疾的影响

基本信息

批准号：
10785316
负责人：
Juleen Rodakowski
金额：
$ 3.5万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-01 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10785316
关键词：
Age-associated memory impairment Aging Alzheimer&apos s Disease Amyloid beta-Protein Behavioral Brain Brain imaging Clinical Trials Cognitive remediation Communities Complex Deposition Disabled Persons Elderly Executive Dysfunction Family Funding Opportunities Future Glean Goals Home Impaired cognition Individual Intervention Life Measures Medication Errors Monitor Neurocognitive Nursing Homes Occupational Therapist Outcome Pathology Patient Self-Report Performance Pharmacologic Substance Physical Exercise Pittsburgh Compound-B Positron-Emission Tomography Problem Solving Randomized, Controlled Trials Reporting Research Research Infrastructure Research Project Grants Sampling Schedule Self Assessment Self Care Testing Training Treatment Efficacy abeta deposition cognitive ability cognitive performance cognitive testing cooking design disability efficacy testing executive function experience follow up assessment informant innovation intervention refinement mild cognitive impairment novel older women performance based measurement pharmacologic phase II trial real world application skills social therapy design treatment as usual treatment response

项目摘要

PROJECT SUMMARY/ABSTRACT Loss of cognitive abilities leading to Alzheimer's disease is progressive and destructive, leaving older adults disabled and unable to recall their past. The number of older adults with Alzheimer's disease is expected to triple by the year 2050, yet little research examines amyloid beta (Aβ) deposition, executive function, and progression of disability. Even less examines non-pharmacological interventions designed to slow progression to disability for these older adults. We propose to test the influence of a novel and promising non- pharmacological intervention on progression of disability in a sample of 150 older adults with Mild Cognitive Impairment (MCI) who have previously completed Positron Emission Tomography (PET) Imaging with Pittsburgh Compound B (PiB). Our intervention is Strategy Training. Strategy training optimizes engagement in meaningful daily activities through generating self-selected goals, monitoring daily activities, scheduling activities, and problem-solving solutions to barriers experienced when engaging in activities. Occupational therapists deliver Strategy Training in older adults' homes to enhance real-world application. We completed a preliminary randomized controlled trial of Strategy Training (N=30), and we found a moderate effect size (Cohen's d = 0.54) for between-group differences on disability at 6 months. In this Phase II trial, we will test the effect of Strategy Training compared to Enhanced Usual Care on change in disability among older adults with MCI and assess the extent to which brain imaging and neurocognitive function modify the relationship between Strategy Training and Enhanced Usual Care on change in disability. Interventions, such as Strategy Training, focused on slowing emergence of disability despite underlying pathology may keep older adults as engaged in meaningful daily activities for as long as possible. This project tests a novel and promising non- pharmacological intervention and will inform our understanding of important effect modifiers -Aβ deposition and executive function- on change in performance of cognitively challenging daily activities. Enhancing our understanding of Aβ deposition, executive function, disability, and a promising non-pharmacological intervention could support aging for millions of older adults who, in our near future, will experience disability related to MCI.

项目总结/摘要认知能力丧失导致阿尔茨海默病是渐进性和破坏性的，残疾人无法回忆起他们的过去老年痴呆症患者的数量预计将到2050年将增加两倍，但很少有研究检查淀粉样蛋白β（Aβ）沉积，执行功能，残疾的进展。更不用说研究旨在减缓进展的非药物干预 to disability残疾for these older老adults成年人.我们建议测试一个新的和有前途的非- 药物干预对150例轻度认知功能障碍老年人残疾进展的影响既往已完成正电子发射断层扫描（PET）成像，匹兹堡化合物B（PiB）。我们的干预是策略训练。战略培训优化了参与有意义的日常活动，通过产生自我选择的目标，监控日常活动，安排活动，并解决问题的解决方案，在从事活动时遇到的障碍。职业治疗师在老年人家中提供策略培训，以增强现实世界的应用。我们完成了策略训练的初步随机对照试验（N=30），我们发现一个中等的效果大小（Cohen's d = 0.54），用于6个月时残疾的组间差异。在第二阶段试验中，我们将测试策略培训与加强家庭护理对老年人残疾变化的影响 MCI，并评估脑成像和神经认知功能在多大程度上改变了关于残疾变化的战略培训和加强的家庭护理。干预措施，如战略培训，尽管存在潜在的病理学，但专注于减缓残疾的出现可能会使老年人继续参与有意义的日常活动尽可能长。这个项目测试了一个新颖的和有前途的非- 药理学干预，并将告知我们对重要效应调节剂-Aβ沉积和执行功能-认知挑战性日常活动的表现发生变化。加强我们了解Aβ沉积，执行功能，残疾，以及一种有前途的非药物干预可以支持数百万老年人的老龄化，在不久的将来，他们将经历残疾与MCI有关

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Developing a digital music program for older adults with changing cognition: A program development report.

为认知不断变化的老年人开发数字音乐程序：程序开发报告。

DOI：
发表时间：
2022
期刊：
Music and medicine
影响因子：
0
作者：
Dorris,JennieL;DiCicco,Heather;Becker,JamesT;Rodakowski,Juleen
通讯作者：
Rodakowski,Juleen

Caring for Family Caregivers: Perceptions of CARE Act Compliance and Implementation.

DOI：
10.1097/qmh.0000000000000278
发表时间：
2021
期刊：
Quality management in health care
影响因子：
1.2
作者：
Rodakowski J;Leighton C;Martsolf GR;James AE
通讯作者：
James AE

Music Intervention Pilot Study: Assessing Teaching Methods of Group Marimba Classes Designed to Train Spatial Skills of Older Adults with Changes in Cognition.

DOI：
10.47513/mmd.v13i4.749
发表时间：
2021-10
期刊：
Music and medicine
影响因子：
0
作者：
Rodakowski J;Dorris JL;McLaughlin DJ;Grimes DL
通讯作者：
Grimes DL

Project Unmute: A Digital Music Program Delivered by Adolescent Musicians to Older Adults with Cognitive Decline.

DOI：
10.1080/15350770.2022.2086958
发表时间：
2022
期刊：
JOURNAL OF INTERGENERATIONAL RELATIONSHIPS
影响因子：
1.4
作者：
Dorris, Jennie L.;Chang, Kyle;McLaughlin, Diana J.;Murray, Shaun S.;Schaumburg, Savannah;Rodakowski, Juleen
通讯作者：
Rodakowski, Juleen

Effects of music participation for mild cognitive impairment and dementia: A systematic review and meta-analysis.