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Influence of Strategy Training on Disability for Older Adults with Mild Cognitive Impairment

策略训练对轻度认知障碍老年人残疾的影响

基本信息

批准号：
10322416
负责人：
Juleen Rodakowski
金额：
$ 60.43万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-01 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10322416
关键词：
Age-associated memory impairment Aging Alzheimer&apos s Disease Amyloid beta-Protein Behavioral Brain Brain imaging Clinical Trials Cognitive remediation Communities Complex Disabled Persons Elderly Executive Dysfunction Family Funding Opportunities Future Glean Goals Home Impaired cognition Individual Intervention Life Measures Medication Errors Monitor Neurocognitive Nursing Homes Occupational Therapist Outcome Pathology Patient Self-Report Performance Pharmacologic Substance Pharmacology Physical Exercise Pittsburgh Compound-B Positron-Emission Tomography Problem Solving Randomized Controlled Trials Reporting Research Research Infrastructure Research Project Grants Sampling Schedule Self Assessment Self Care Testing Training Treatment Efficacy Woman abeta deposition cognitive ability cognitive performance cooking design disability efficacy testing executive function experience follow up assessment informant innovation mild cognitive impairment novel performance based measurement phase II trial real world application skills social therapy design treatment as usual treatment response

项目摘要

PROJECT SUMMARY/ABSTRACT Loss of cognitive abilities leading to Alzheimer's disease is progressive and destructive, leaving older adults disabled and unable to recall their past. The number of older adults with Alzheimer's disease is expected to triple by the year 2050, yet little research examines amyloid beta (Aβ) deposition, executive function, and progression of disability. Even less examines non-pharmacological interventions designed to slow progression to disability for these older adults. We propose to test the influence of a novel and promising non- pharmacological intervention on progression of disability in a sample of 150 older adults with Mild Cognitive Impairment (MCI) who have previously completed Positron Emission Tomography (PET) Imaging with Pittsburgh Compound B (PiB). Our intervention is Strategy Training. Strategy training optimizes engagement in meaningful daily activities through generating self-selected goals, monitoring daily activities, scheduling activities, and problem-solving solutions to barriers experienced when engaging in activities. Occupational therapists deliver Strategy Training in older adults' homes to enhance real-world application. We completed a preliminary randomized controlled trial of Strategy Training (N=30), and we found a moderate effect size (Cohen's d = 0.54) for between-group differences on disability at 6 months. In this Phase II trial, we will test the effect of Strategy Training compared to Enhanced Usual Care on change in disability among older adults with MCI and assess the extent to which brain imaging and neurocognitive function modify the relationship between Strategy Training and Enhanced Usual Care on change in disability. Interventions, such as Strategy Training, focused on slowing emergence of disability despite underlying pathology may keep older adults as engaged in meaningful daily activities for as long as possible. This project tests a novel and promising non- pharmacological intervention and will inform our understanding of important effect modifiers -Aβ deposition and executive function- on change in performance of cognitively challenging daily activities. Enhancing our understanding of Aβ deposition, executive function, disability, and a promising non-pharmacological intervention could support aging for millions of older adults who, in our near future, will experience disability related to MCI.

项目总结/文摘