STRUCTURAL BASIS OF AMBLYOPIA & STRABISMUS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：在视网膜膝状体突触处的突发发射的传输：在视觉系统中，来自视网膜的输出在传输到皮质之前通过称为外侧膝状体核（LGN）的丘脑中继站进行过滤。给定的视网膜动作电位在膝状体神经元中产生动作电位的概率通常远小于100%。然而，一个单一的视网膜锋电位可能产生一个以上的膝状体锋电位，因为LGN放电行为存在两种模式：强直和爆发。突发尖峰被定义为那些发生在100 ms的暂停后，与小于4 ms的尖峰间期。在沉默期，低阈值Ca 2+电流（IT）变得去激活。随后，一个单一的视网膜EPSP可以引起膝状体动作电位的爆发骑在一个大的去极化钙电流。我们测试了在自然刺激期间，当LGN神经元以爆发模式而不是强直模式发射时，功效会发生什么。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Transmission of Burst Firing at the Retinogeniculate Synapse: In the visual system, output from the retina is filtered through a thalamic relay station called the lateral geniculate nucleus (LGN) before transmission to the cortex. The probability that a given retinal action potential generates an action potential in a geniculate neuron is usually much less than 100%. It is possible, however, for a single retinal spike to generate more than one geniculate spike, because LGN firing behavior exists in two modes: tonic and burst. Burst spikes are defined as those occurring after a 100 ms pause, with an interspike interval of less than 4 ms. During the silent period, the low-threshold Ca2+ current (IT) becomes de-inactivated. Subsequently, a single retinal EPSP can cause a burst of geniculate action potentials riding on a large depolarizing Ca2+ current. We tested what happens to efficacy when an LGN neuron fires in burst mode, rather than tonic mode, during natural stimulation.